MOUSE:TYRO

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tyr
Protein Name(s)	Tyrosinase Albino locus protein Monophenol monooxygenase
External Links
UniProt	P11344
EMBL	D00440 D00131 M20234 X12782 M26729 M24560 D00439 X51743
CCDS	CCDS52304.1
PIR	A27711
RefSeq	NP_035791.1
UniGene	Mm.238127
ProteinModelPortal	P11344
SMR	P11344
BioGrid	204394
IntAct	P11344
BindingDB	P11344
ChEMBL	CHEMBL5346
PhosphoSite	P11344
PRIDE	P11344
Ensembl	ENSMUST00000004770
GeneID	22173
KEGG	mmu:22173
UCSC	uc009ifo.1
CTD	7299
MGI	MGI:98880
eggNOG	NOG08919
HOGENOM	HOG000118376
HOVERGEN	HBG003553
InParanoid	P11344
KO	K00505
OMA	CLSLTQY
OrthoDB	EOG7TJ3HG
PhylomeDB	P11344
TreeFam	TF315865
NextBio	302123
PRO	PR:P11344
Proteomes	UP000000589
Bgee	P11344
CleanEx	MM_TYR
ExpressionAtlas	P11344
Genevestigator	P11344
GO	GO:0016021 GO:0042470 GO:0033162 GO:0048471 GO:0005507 GO:0004503 GO:0046982 GO:0042803 GO:0008283 GO:0042438 GO:0043473 GO:0048538
Gene3D	1.10.1280.10
InterPro	IPR002227 IPR008922
Pfam	PF00264
PRINTS	PR00092
SUPFAM	SSF48056
PROSITE	PS00497 PS00498

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0042470	melanosome	PMID:26620560^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9918801^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9918801^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	PMID:9918801^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98880 PANTHER:PTN001352375 RGD:1589755 ZFIN:ZDB-GENE-991026-3	P		Seeded From UniProt	complete
colocalizes_with	GO:0042470	melanosome	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98880 PANTHER:PTN001352375 UniProtKB:P14679	C		Seeded From UniProt	complete
involved_in	GO:0042438	melanin biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98880 PANTHER:PTN001352375 UniProtKB:P14679	P		Seeded From UniProt	complete
enables	GO:0004503	monophenol monooxygenase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001352375 UniProtKB:P14679	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	PMID:10890980^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856308	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:9548375^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:17247639^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855978	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	PMID:13880466^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043473	pigmentation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589755	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	PMID:22275436^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0042470	melanosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042438	melanin biosynthetic process	PMID:9548375^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855976	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042438	melanin biosynthetic process	PMID:7665913^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855978	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042438	melanin biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:9548375^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1855976	P	acts_on_population_of:(CL:0000148)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589755	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1589755	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	F		Seeded From UniProt	complete
enables	GO:0004503	monophenol monooxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P14679	F		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	P		Seeded From UniProt	complete
involved_in	GO:0033280	response to vitamin D	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A9G4 ensembl:ENSRNOP00000021971	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:L8B082 ensembl:ENSP00000263321	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	C		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	C		Seeded From UniProt	complete
involved_in	GO:0042438	melanin biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	C		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	F		Seeded From UniProt	complete
enables	GO:0004503	monophenol monooxygenase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P14679 ensembl:ENSP00000263321	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002227	F		Seeded From UniProt	complete
enables	GO:0004503	monophenol monooxygenase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.14.18.1	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:9918801^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004503	monophenol monooxygenase activity	PMID:9918801^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042438	melanin biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0470	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004497	monooxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0503	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
part_of	GO:0033162	melanosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0160	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Marubashi, S et al. (2016) RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J. Biol. Chem. 291 1427-40 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Jiménez-Cervantes, C et al. (1998) Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. Biochem. Biophys. Res. Commun. 253 761-7 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ DeRossi, C et al. (2000) Mouse fzd4 maps within a region of chromosome 7 important for thymus and cardiac development. Genesis 27 64-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hirobe, T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur. J. Cell Biol. 75 184-91 PubMed GONUTS page
↑ Markert, CL & Silvers, WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41 429-50 PubMed GONUTS page
↑ COLEMAN, DL (1962) Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch. Biochem. Biophys. 96 562-8 PubMed GONUTS page
↑ Ohbayashi, N et al. (2012) Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J. Cell. Sci. 125 1508-18 PubMed GONUTS page
↑ Ozeki, H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J. Invest. Dermatol. 105 361-6 PubMed GONUTS page

[PMID:26620560-1] Marubashi, S et al. (2016) RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes. J. Biol. Chem. 291 1427-40 PubMed GONUTS page

[PMID:9918801-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Jiménez-Cervantes, C et al. (1998) Molecular interactions within the melanogenic complex: formation of heterodimers of tyrosinase and TRP1 from B16 mouse melanoma. Biochem. Biophys. Res. Commun. 253 761-7 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10890980-4] DeRossi, C et al. (2000) Mouse fzd4 maps within a region of chromosome 7 important for thymus and cardiac development. Genesis 27 64-75 PubMed GONUTS page

[PMID:9548375-5] 5.0 ^5.1 ^5.2 Hirobe, T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur. J. Cell Biol. 75 184-91 PubMed GONUTS page

[PMID:17247639-6] Markert, CL & Silvers, WK (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics 41 429-50 PubMed GONUTS page

[PMID:13880466-7] COLEMAN, DL (1962) Effect of genic substitution on the incorporation of tyrosine into the melanin of mouse skin. Arch. Biochem. Biophys. 96 562-8 PubMed GONUTS page

[PMID:22275436-8] Ohbayashi, N et al. (2012) Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes. J. Cell. Sci. 125 1508-18 PubMed GONUTS page

[PMID:7665913-9] Ozeki, H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J. Invest. Dermatol. 105 361-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

MOUSE:TYRO

Contents

Annotations

Notes

References

c

e

g

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools