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MOUSE:TUB

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Tub (synonyms: Rd5)
Protein Name(s) Tubby protein
External Links
UniProt P50586
EMBL U54643
U52433
U52824
AJ296303
CCDS CCDS21732.1
PIR S68518
RefSeq NP_068685.1
UniGene Mm.439722
PDB 1C8Z
1I7E
PDBsum 1C8Z
1I7E
ProteinModelPortal P50586
SMR P50586
BioGrid 204371
PhosphoSite P50586
MaxQB P50586
PRIDE P50586
Ensembl ENSMUST00000033341
ENSMUST00000119474
GeneID 22141
KEGG mmu:22141
UCSC uc009jdf.1
CTD 7275
MGI MGI:2651573
eggNOG NOG286778
GeneTree ENSGT00610000085970
HOGENOM HOG000016044
HOVERGEN HBG018010
InParanoid P50586
OMA ATMQRKG
OrthoDB EOG77HDDQ
PhylomeDB P50586
TreeFam TF314076
EvolutionaryTrace P50586
NextBio 302034
PRO PR:P50586
Proteomes UP000000589
Bgee P50586
CleanEx MM_TUB
ExpressionAtlas P50586
Genevestigator P50586
GO GO:0005829
GO:0005576
GO:0005634
GO:0005886
GO:0044259
GO:0006910
GO:0045494
GO:0050766
GO:0097500
GO:0009725
GO:0060041
GO:0007605
Gene3D 3.20.90.10
InterPro IPR000007
IPR025659
IPR018066
IPR005398
Pfam PF01167
PRINTS PR01573
PR01574
SUPFAM SSF54518
PROSITE PS01200
PS01201

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

GO0021766

hippocampus development

PMID:23351594[1]

ECO:0000314

P

According to Figure 4A, B, in both the hippocampus and the hypothalamus regions of the tubby brain SSTR3 is essentially undetectable or greatly diminished.

Missing: Valid GO ID
CACAO 7538

involved_in

GO:0050766

positive regulation of phagocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P50607

P

Seeded From UniProt

complete

involved_in

GO:1903546

protein localization to photoreceptor outer segment

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109571
MGI:MGI:2651573
PANTHER:PTN000421365

P

Seeded From UniProt

complete

involved_in

GO:0097500

receptor localization to non-motile cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2651573
PANTHER:PTN000421365

P

Seeded From UniProt

complete

involved_in

GO:0061512

protein localization to cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015721
PANTHER:PTN000421275

P

Seeded From UniProt

complete

enables

GO:0035091

phosphatidylinositol binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000421275
UniProtKB:O75386

F

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015721
MGI:MGI:1329045
PANTHER:PTN000421275
UniProtKB:O75386

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042073

intraciliary transport

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008277

regulation of G protein-coupled receptor signaling pathway

PMID:28154160[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:21052544[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:11925566[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006910

phagocytosis, recognition

PMID:19837063[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006910

phagocytosis, recognition

PMID:20978472[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11925566[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:19695251[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903546

protein localization to photoreceptor outer segment

PMID:23351594[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903441

protein localization to ciliary membrane

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O88808

P

Seeded From UniProt

complete

enables

GO:0120160

intraciliary transport particle A binding

PMID:28154160[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097500

receptor localization to non-motile cilium

PMID:24316073[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097500

receptor localization to non-motile cilium

PMID:23351594[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

  • occurs_in:(EMAPA:16894)
  • occurs_in:(CL:0000540)
  • has_direct_input:(UniProtKB:Q8JZL2)|occurs_in(EMAPA:16894)
  • occurs_in:(CL:0000540)
  • has_direct_input:(UniProtKB:P30935)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061512

protein localization to cilium

PMID:28154160[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

has_input:(MGI:MGI:2180756)|has_input:(MGI:MGI:108418)|has_input:(MGI:MGI:98329)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060041

retina development in camera-type eye

PMID:21052544[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050766

positive regulation of phagocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045494

photoreceptor cell maintenance

PMID:10629044[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857081

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P50607

F

Seeded From UniProt

complete

involved_in

GO:0009725

response to hormone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O88808
ensembl:ENSRNOP00000064486

P

Seeded From UniProt

complete

enables

GO:0120160

intraciliary transport particle A binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

F

Seeded From UniProt

complete

involved_in

GO:0050766

positive regulation of phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

F

Seeded From UniProt

complete

involved_in

GO:0042073

intraciliary transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

C

Seeded From UniProt

complete

enables

GO:0001664

G protein-coupled receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P50607
ensembl:ENSP00000305426

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0050896

response to stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0716

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006909

phagocytosis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0581

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Sun, X et al. (2012) Tubby is required for trafficking G protein-coupled receptors to neuronal cilia. Cilia 1 21 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
  4. ↑ 4.0 4.1 Won, J et al. (2011) Mouse model resources for vision research. J Ophthalmol 2011 391384 PubMed GONUTS page
  5. ↑ 5.0 5.1 Ikeda, A et al. (2002) Microtubule-associated protein 1A is a modifier of tubby hearing (moth1). Nat. Genet. 30 401-5 PubMed GONUTS page
  6. ↑ Caberoy, NB et al. (2010) Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. Exp. Cell Res. 316 245-57 PubMed GONUTS page
  7. ↑ Caberoy, NB et al. (2010) Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 29 3898-910 PubMed GONUTS page
  8. ↑ Caberoy, NB & Li, W (2009) Unconventional secretion of tubby and tubby-like protein 1. FEBS Lett. 583 3057-62 PubMed GONUTS page
  9. ↑ Loktev, AV & Jackson, PK (2013) Neuropeptide Y family receptors traffic via the Bardet-Biedl syndrome pathway to signal in neuronal primary cilia. Cell Rep 5 1316-29 PubMed GONUTS page
  10. ↑ Stubdal, H et al. (2000) Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation. Mol. Cell. Biol. 20 878-82 PubMed GONUTS page
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