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PMID:23351594

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Citation

Sun, X, Haley, J, Bulgakov, OV, Cai, X, McGinnis, J and Li, T (2012) Tubby is required for trafficking G protein-coupled receptors to neuronal cilia. Cilia 1:21

Abstract

Tubby is the founding member of the tubby-like family of proteins. The naturally occurring tubby mutation in mice causes retinitis pigmentosa, hearing loss and obesity. Tubby has been proposed to function as an accessory factor in ciliary trafficking. We directly examined a role for tubby in ciliary trafficking in vivo.

Links

PubMed PMC3599646 Online version:10.1186/2046-2530-1-21

Keywords


Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:OPSG

located_in

GO:0001750: photoreceptor outer segment

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:OPSD

located_in

GO:0001750: photoreceptor outer segment

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SSR3

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SSR3

located_in

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:TUB

involved_in

GO:0097500: receptor localization to non-motile cilium

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

MOUSE:TUB

involved_in

GO:1903546: protein localization to photoreceptor outer segment

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

Seeded From UniProt

complete

MOUSE:OPSB

located_in

GO:0001750: photoreceptor outer segment

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:MCHR1

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:MCHR1

located_in

GO:0043005: neuron projection

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:MCHR1

part_of

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000540)
  • part_of:(EMAPA:32768)|part_of:(CL:0000540)
  • part_of:(EMAPA:35421)

Seeded From UniProt

complete

MOUSE:TUB

acts_upstream_of_or_within

GO:1903546: protein localization to photoreceptor outer segment

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

  • has_direct_input:(UniProtKB:P15409)
  • occurs_in:(EMAPA:17168)|has_direct_input(UniProtKB:P51491)
  • occurs_in:(EMAPA:17168)|has_direct_input(UniProtKB:O35599)
  • occurs_in:(EMAPA:17168)

Seeded From UniProt

complete

MOUSE:TUB

GO0021766: hippocampus development

ECO:0000314:

P

According to Figure 4A, B, in both the hippocampus and the hypothalamus regions of the tubby brain SSTR3 is essentially undetectable or greatly diminished.

Missing: Valid GO ID
CACAO 7538

MOUSE:TUB

acts_upstream_of_or_within

GO:0097500: receptor localization to non-motile cilium

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1861349

P

  • occurs_in:(EMAPA:16894)
  • occurs_in:(CL:0000540)
  • has_direct_input:(UniProtKB:Q8JZL2)|occurs_in(EMAPA:16894)
  • occurs_in:(CL:0000540)
  • has_direct_input:(UniProtKB:P30935)

Seeded From UniProt

complete


See also

References

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