MOUSE:TRPV1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Trpv1
Protein Name(s)	Transient receptor potential cation channel subfamily V member 1 TrpV1 Osm-9-like TRP channel 1 OTRPC1 Vanilloid receptor 1
External Links
UniProt	Q704Y3
EMBL	AY452083 AY452084 AJ620495 AB180097 AY445519 AL663116 AL663116 AL663116 AL663116
CCDS	CCDS25003.1
RefSeq	NP_001001445.1
UniGene	Mm.447485
ProteinModelPortal	Q704Y3
SMR	Q704Y3
BioGrid	228724
DIP	DIP-59791N
STRING	10090.ENSMUSP00000099585
BindingDB	Q704Y3
ChEMBL	CHEMBL1781864
GuidetoPHARMACOLOGY	507
iPTMnet	Q704Y3
PhosphoSitePlus	Q704Y3
PaxDb	Q704Y3
PRIDE	Q704Y3
DNASU	193034
Ensembl	ENSMUST00000102526
GeneID	193034
KEGG	mmu:193034
UCSC	uc007kah.2 uc011xyq.2
CTD	7442
MGI	MGI:1341787
eggNOG	KOG3676 ENOG4110DG4
GeneTree	ENSGT00550000074425
HOGENOM	HOG000234630
HOVERGEN	HBG054085
InParanoid	Q704Y3
KO	K05222
OMA	CHRKEYV
OrthoDB	EOG091G01LY
PhylomeDB	Q704Y3
TreeFam	TF314711
Reactome	[www.reactome.org/content/detail/R-MMU-3295583 R-MMU-3295583]
PRO	PR:Q704Y3
Proteomes	UP000000589
Bgee	ENSMUSG00000005952
ExpressionAtlas	Q704Y3
Genevisible	Q704Y3
GO	GO:0030054 GO:0005829 GO:0030425 GO:0032591 GO:0009897 GO:0016021 GO:0005887 GO:0031226 GO:0016020 GO:0043005 GO:0043025 GO:0005886 GO:0045211 GO:0005524 GO:0005262 GO:0015278 GO:0005261 GO:0008324 GO:0017081 GO:0005231 GO:0005230 GO:0005216 GO:0046872 GO:0035091 GO:0051219 GO:0097603 GO:0004888 GO:0048266 GO:1990035 GO:0070588 GO:0006816 GO:0006812 GO:0071468 GO:0071312 GO:0071318 GO:0034605 GO:1990090 GO:0071502 GO:0071356 GO:0050968 GO:0050965 GO:0050960 GO:0002024 GO:0001660 GO:0014047 GO:0034220 GO:0006629 GO:0001774 GO:0090212 GO:0000122 GO:0002790 GO:0043065 GO:0060454 GO:0045429 GO:0051289 GO:1901594 GO:0009408 GO:0010243 GO:0048265 GO:0043434 GO:0009268 GO:0050954 GO:0019233 GO:0060083 GO:0001659 GO:0014832
Gene3D	1.25.40.20
InterPro	IPR002110 IPR020683 IPR005821 IPR004729 IPR024862 IPR008347 IPR024863
PANTHER	PTHR10582 PTHR10582:SF38
Pfam	PF12796 PF00520
PRINTS	PR01768
SMART	SM00248
SUPFAM	SSF48403
TIGRFAMs	TIGR00870
PROSITE	PS50297 PS50088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0070073	clustering of voltage-gated calcium channels	PMID:27693258^[1]	ECO:0000314			P		TRPV1 forms clusters with multiple voltage-gated calcium channels, as seen in Figure 7A, with additional detail of these calcium channel clusters seen in Figure 8C. These calcium channel clusters form only in the presence of at least one TRPV1 channel. Uniprot Nomenclature: Transient receptor potential cation channel subfamily V member 1 (TRPV1_MOUSE) Uniprot ID: Q704Y3 Organism: Mus musculus	complete CACAO 12560
	GO:0045163	clustering of voltage-gated potassium channels	PMID:27693258^[1]	ECO:0000314			P		TRPV1 forms clusters with voltage-gated potassium channels of KCNQ2, as seen in Figures 6A and 8A. Uniprot Nomenclature: Transient receptor potential cation channel subfamily V member 1 (TRPV1_MOUSE) Uniprot ID: Q704Y3 Organism: Mus musculus	complete CACAO 12563
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	C		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:1901594	response to capsazepine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:0071468	cellular response to acidic pH	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23021218^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000136) has_regulation_target:(UniProtKB:O70343)	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:22634729^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	PMID:22634729^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8BHY3	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:22634729^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1001451)	Seeded From UniProt	complete
enables	GO:0097603	temperature-gated ion channel activity	PMID:22634729^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:1001451)	Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	C		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
enables	GO:0005231	excitatory extracellular ligand-gated ion channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000061616 RGD:628841 RGD:69335 UniProtKB:Q9H1D0 UniProtKB:Q9NQA5	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:1341836 MGI:MGI:1926945 MGI:MGI:1927259 MGI:MGI:2429764 PANTHER:PTN000832860 RGD:620636 RGD:69335 RGD:69337 SGD:S000005613 UniProtKB:F1RIT1 UniProtKB:Q9H1D0 UniProtKB:Q9HBA0 UniProtKB:Q9NQA5 WB:WBGene00003889	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341787 MGI:MGI:2181407 PANTHER:PTN000061616	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901594	response to capsazepine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901594	response to capsazepine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
enables	GO:0097603	temperature-gated ion channel activity	PMID:18455988^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090212	negative regulation of establishment of blood-brain barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071468	cellular response to acidic pH	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071468	cellular response to acidic pH	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071318	cellular response to ATP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071312	cellular response to alkaloid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070588	calcium ion transmembrane transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060454	positive regulation of gastric acid secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060083	smooth muscle contraction involved in micturition	PMID:12161756^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P	has_participant:(EMAPA:18321)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051289	protein homotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	PMID:18297068^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050968	detection of chemical stimulus involved in sensory perception of pain	PMID:18272293^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050960	detection of temperature stimulus involved in thermoception	PMID:18455988^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050954	sensory perception of mechanical stimulus	PMID:12161756^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P	has_participant:(EMAPA:35897)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048266	behavioral response to pain	PMID:18272658^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048266	behavioral response to pain	PMID:17767493^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048266	behavioral response to pain	PMID:18455988^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048265	response to pain	PMID:18297068^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048265	response to pain	PMID:18272293^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:11466438^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18321) part_of:(CL:0000101)	Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034605	cellular response to heat	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:10764638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
enables	GO:0017081	chloride channel regulator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35433	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:15883036^[13]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z182	C		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014832	urinary bladder smooth muscle contraction	PMID:12161756^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P	has_participant:(EMAPA:18321)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014047	glutamate secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010917	negative regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010459	negative regulation of heart rate	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010243	response to organonitrogen compound	PMID:17767493^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	PMID:10764638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009408	response to heat	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009268	response to pH	PMID:10764638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009268	response to pH	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35433	P		Seeded From UniProt	complete
enables	GO:0008324	cation transmembrane transporter activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35433	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:17767493^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:17194758^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006812	cation transport	PMID:15883036^[13]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z182	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:12161756^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:18455988^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:17767493^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:10764638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	PMID:15883036^[13]	ECO:0000247	sequence alignment evidence used in manual assertion	UniProtKB:Q9Z182	F		Seeded From UniProt	complete
enables	GO:0005231	excitatory extracellular ligand-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NER1	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002790	peptide secretion	PMID:18172555^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029186	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002024	diet induced thermogenesis	PMID:12161756^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628841	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001660	fever generation	PMID:15763167^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001659	temperature homeostasis	PMID:10764638^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1934023	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015278	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0015278	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015278	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005231	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005231	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005231	P		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:1901594	response to capsazepine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0090212	negative regulation of establishment of blood-brain barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071502	cellular response to temperature stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071468	cellular response to acidic pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071363	cellular response to growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0071312	cellular response to alkaloid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0060454	positive regulation of gastric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0035091	phosphatidylinositol binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
enables	GO:0017081	chloride channel regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0015276	ligand-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
involved_in	GO:0014047	glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0010917	negative regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0010459	negative regulation of heart rate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
involved_in	GO:0009408	response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0009268	response to pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
enables	GO:0008324	cation transmembrane transporter activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0005261	cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0005231	excitatory extracellular ligand-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	F		Seeded From UniProt	complete
involved_in	GO:0003085	negative regulation of systemic arterial blood pressure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35433 ensembl:ENSRNOP00000026493	P		Seeded From UniProt	complete
involved_in	GO:1901594	response to capsazepine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	P		Seeded From UniProt	complete
involved_in	GO:0098703	calcium ion import across plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	P		Seeded From UniProt	complete
involved_in	GO:0071468	cellular response to acidic pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	P		Seeded From UniProt	complete
enables	GO:0051219	phosphoprotein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	F		Seeded From UniProt	complete
involved_in	GO:0050955	thermoception	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	C		Seeded From UniProt	complete
enables	GO:0005230	extracellular ligand-gated ion channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8NER1 ensembl:ENSP00000459962	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR024862 InterPro:IPR024863	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821 InterPro:IPR008347 InterPro:IPR024862 InterPro:IPR024863	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008347 InterPro:IPR024862 InterPro:IPR024863	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	PMID:15194687^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20351268^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q704Y3-1	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628 UniProtKB-SubCell:SL-0219	C		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0032591	dendritic spine membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0285	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhang, J et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92 461-478 PubMed GONUTS page
↑ Ye, L et al. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151 96-110 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Cho, H et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat. Neurosci. 15 1015-21 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Kim, AY et al. (2008) Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell 133 475-85 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Birder, LA et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat. Neurosci. 5 856-60 PubMed GONUTS page
↑ ^7.0 ^7.1 Salazar, H et al. (2008) A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat. Neurosci. 11 255-61 PubMed GONUTS page
↑ ^8.0 ^8.1 Andrade, EL et al. (2008) Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience 152 511-20 PubMed GONUTS page
↑ Taylor, AC et al. (2008) Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R1285-93 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Koo, JY et al. (2007) Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur. J. Neurosci. 26 1139-47 PubMed GONUTS page
↑ Vlaskovska, M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21 5670-7 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Caterina, MJ et al. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288 306-13 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Lee, SY (2005) Identification of a protein that interacts with the vanilloid receptor. Biochem. Biophys. Res. Commun. 331 1445-51 PubMed GONUTS page
↑ Pareek, TK et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. U.S.A. 104 660-5 PubMed GONUTS page
↑ Leffler, A et al. (2008) The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J. Clin. Invest. 118 763-76 PubMed GONUTS page
↑ Iida, T et al. (2005) Attenuated fever response in mice lacking TRPV1. Neurosci. Lett. 378 28-33 PubMed GONUTS page
↑ Hu, HZ et al. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279 35741-8 PubMed GONUTS page
↑ Yang, F et al. (2010) Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl. Acad. Sci. U.S.A. 107 7083-8 PubMed GONUTS page

[PMID:27693258-1] 1.0 ^1.1 Zhang, J et al. (2016) Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons. Neuron 92 461-478 PubMed GONUTS page

[PMID:23021218-2] Ye, L et al. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell 151 96-110 PubMed GONUTS page

[PMID:22634729-3] 3.0 ^3.1 ^3.2 ^3.3 Cho, H et al. (2012) The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat. Neurosci. 15 1015-21 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18455988-5] 5.0 ^5.1 ^5.2 ^5.3 Kim, AY et al. (2008) Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1. Cell 133 475-85 PubMed GONUTS page

[PMID:12161756-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Birder, LA et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat. Neurosci. 5 856-60 PubMed GONUTS page

[PMID:18297068-7] 7.0 ^7.1 Salazar, H et al. (2008) A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat. Neurosci. 11 255-61 PubMed GONUTS page

[PMID:18272293-8] 8.0 ^8.1 Andrade, EL et al. (2008) Pronociceptive response elicited by TRPA1 receptor activation in mice. Neuroscience 152 511-20 PubMed GONUTS page

[PMID:18272658-9] Taylor, AC et al. (2008) Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 R1285-93 PubMed GONUTS page

[PMID:17767493-10] 10.0 ^10.1 ^10.2 ^10.3 Koo, JY et al. (2007) Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur. J. Neurosci. 26 1139-47 PubMed GONUTS page

[PMID:11466438-11] Vlaskovska, M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21 5670-7 PubMed GONUTS page

[PMID:10764638-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Caterina, MJ et al. (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288 306-13 PubMed GONUTS page

[PMID:15883036-13] 13.0 ^13.1 ^13.2 Lee, SY (2005) Identification of a protein that interacts with the vanilloid receptor. Biochem. Biophys. Res. Commun. 331 1445-51 PubMed GONUTS page

[PMID:17194758-14] Pareek, TK et al. (2007) Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc. Natl. Acad. Sci. U.S.A. 104 660-5 PubMed GONUTS page

[PMID:18172555-15] Leffler, A et al. (2008) The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J. Clin. Invest. 118 763-76 PubMed GONUTS page

[PMID:15763167-16] Iida, T et al. (2005) Attenuated fever response in mice lacking TRPV1. Neurosci. Lett. 378 28-33 PubMed GONUTS page

[PMID:15194687-17] Hu, HZ et al. (2004) 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3. J. Biol. Chem. 279 35741-8 PubMed GONUTS page

[PMID:20351268-18] Yang, F et al. (2010) Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc. Natl. Acad. Sci. U.S.A. 107 7083-8 PubMed GONUTS page

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MOUSE:TRPV1

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