PMID:15763167

Citation	Iida, T, Shimizu, I, Nealen, ML, Campbell, A and Caterina, M (2005) Attenuated fever response in mice lacking TRPV1. Neurosci. Lett. 378:28-33
Abstract	TRPV1, the capsaicin receptor, is expressed not only in nociceptive neurons, but also in other locations, including the hypothalamus. Studies involving systemic or intrahypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control. To explore this possibility, we examined thermoregulatory responses in TRPV1-/- mice. These mutant animals exhibited no obvious changes in circadian body temperature fluctuation, tolerance to increased (35 degrees C) or decreased (4 degrees C) ambient temperature or ethanol-induced hypothermia. In contrast, fever production in response to the bacterial pyrogen, lipopolysaccharide (LPS) was significantly attenuated in TRPV1-/- mice. Despite this finding, we detected no significant differences between TRPV1-/- and control mice in the extent of LPS-induced c-Fos expression in numerous fever-related brain subregions. These results suggest that TRPV1 participates in the generation of polyphasic fever, perhaps at sites outside the brain.
Links	PubMed Online version:10.1016/j.neulet.2004.12.007
Keywords	Animals; Body Temperature Regulation/genetics; Brain/drug effects; Brain/metabolism; Circadian Rhythm/drug effects; Circadian Rhythm/physiology; Cold Temperature; Fever/chemically induced; Fever/genetics; Hot Temperature; Ion Channels/deficiency; Lipopolysaccharides/pharmacology; Male; Mice; Mice, Mutant Strains; Proto-Oncogene Proteins c-fos/biosynthesis; Pyrogens/pharmacology; TRPV Cation Channels
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