MOUSE:TET1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tet1 (synonyms: Cxxc6, Kiaa1676)
Protein Name(s)	Methylcytosine dioxygenase TET1 CXXC-type zinc finger protein 6 Ten-eleven translocation 1 gene protein homolog
External Links
UniProt	Q3URK3
EMBL	AC166359 AK010953 AK141438 AK129421
CCDS	CCDS48581.1
RefSeq	NP_081660.1
UniGene	Mm.17774
ProteinModelPortal	Q3URK3
SMR	Q3URK3
BioGrid	206599
IntAct	Q3URK3
STRING	10090.ENSMUSP00000097266
PhosphoSite	Q3URK3
PaxDb	Q3URK3
PRIDE	Q3URK3
Ensembl	ENSMUST00000050826
GeneID	52463
KEGG	mmu:52463
UCSC	uc007fje.2
CTD	80312
MGI	MGI:1098693
eggNOG	NOG236009
GeneTree	ENSGT00510000046514
InParanoid	Q3URK3
KO	K13097
PhylomeDB	Q3URK3
Reactome	REACT_223022
NextBio	308987
PRO	PR:Q3URK3
Proteomes	UP000000589
Bgee	Q3URK3
ExpressionAtlas	Q3URK3
Genevestigator	Q3URK3
GO	GO:0005634 GO:0005506 GO:0070579 GO:0043566 GO:0008270 GO:0016568 GO:0080111 GO:0001826 GO:0045944 GO:0006493 GO:0044030 GO:0019827 GO:0006351
InterPro	IPR024779 IPR002857
Pfam	PF12851 PF02008
PROSITE	PS51058

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0048813	dendrite morphogenesis	PMID:26711116^[1]	ECO:0000315			P	In figure 7 (C and D), Tet knockdown impairs dendritic arborization of murine cerebellar granule cells without affecting granule cell migration.	complete CACAO 12850
involved_in	GO:0031062	positive regulation of histone methylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	PMID:21496894^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	PMID:19372391^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	PMID:21778364^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	PMID:19372391^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23352454^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
involved_in	GO:0019827	stem cell population maintenance	PMID:19372391^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006493	protein O-linked glycosylation	PMID:23352454^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19372391^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
involved_in	GO:0001826	inner cell mass cell differentiation	PMID:19372391^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098693 MGI:MGI:2443298 MGI:MGI:2446229 PANTHER:PTN000599488 UniProtKB:Q6N021 UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
involved_in	GO:0070989	oxidative demethylation	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000599488 ZFIN:ZDB-GENE-090312-98	P	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098693 MGI:MGI:2443298 MGI:MGI:2446229 PANTHER:PTN000599488 UniProtKB:Q6N021 UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263392 MGI:MGI:1098693 MGI:MGI:2443298 PANTHER:PTN000599488 UniProtKB:O43151 UniProtKB:Q6N021	P	Seeded From UniProt	complete
involved_in	GO:0006211	5-methylcytosine catabolic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000599488 UniProtKB:Q6N021	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0263392 MGI:MGI:1098693 MGI:MGI:2446229 PANTHER:PTN000599488	C	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000599488 UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000653	regulation of genetic imprinting	PMID:24291790^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4120924	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090310	negative regulation of methylation-dependent chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0080111	DNA demethylation	PMID:20639862^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0080111	DNA demethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044030	regulation of DNA methylation	PMID:21295276^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031062	positive regulation of histone methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20639862^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005506	iron ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q8NFU7	F	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001826	inner cell mass cell differentiation	PMID:21295276^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001826	inner cell mass cell differentiation	PMID:20639862^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F	Seeded From UniProt	complete
involved_in	GO:0006211	5-methylcytosine catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040175	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002857	F	Seeded From UniProt	complete
enables	GO:0070579	methylcytosine dioxygenase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040175	F	Seeded From UniProt	complete
involved_in	GO:0080111	DNA demethylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040175	P	Seeded From UniProt	complete
involved_in	GO:0035511	oxidative DNA demethylation	Reactome:R-MMU-5220944 Reactome:R-MMU-5220936 Reactome:R-MMU-5220931	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-5220944 Reactome:R-MMU-5220936 Reactome:R-MMU-5220931	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhu, X et al. (2016) Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation. Neuron 89 100-12 PubMed GONUTS page
↑ Guo, JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145 423-34 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tahiliani, M et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324 930-5 PubMed GONUTS page
↑ Ito, S et al. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333 1300-3 PubMed GONUTS page
↑ ^5.0 ^5.1 Vella, P et al. (2013) Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol. Cell 49 645-56 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Yamaguchi, S et al. (2013) Role of Tet1 in erasure of genomic imprinting. Nature 504 460-4 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Ito, S et al. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466 1129-33 PubMed GONUTS page
↑ ^9.0 ^9.1 Koh, KP et al. (2011) Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8 200-13 PubMed GONUTS page

[PMID:26711116-1] Zhu, X et al. (2016) Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation. Neuron 89 100-12 PubMed GONUTS page

[PMID:21496894-2] Guo, JU et al. (2011) Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 145 423-34 PubMed GONUTS page

[PMID:19372391-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Tahiliani, M et al. (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324 930-5 PubMed GONUTS page

[PMID:21778364-4] Ito, S et al. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333 1300-3 PubMed GONUTS page

[PMID:23352454-5] 5.0 ^5.1 Vella, P et al. (2013) Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells. Mol. Cell 49 645-56 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24291790-7] Yamaguchi, S et al. (2013) Role of Tet1 in erasure of genomic imprinting. Nature 504 460-4 PubMed GONUTS page

[PMID:20639862-8] 8.0 ^8.1 ^8.2 Ito, S et al. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 466 1129-33 PubMed GONUTS page

[PMID:21295276-9] 9.0 ^9.1 Koh, KP et al. (2011) Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell 8 200-13 PubMed GONUTS page

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MOUSE:TET1

Contents

Annotations

Notes

References

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