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MOUSE:TCL1A
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Tcl1a (synonyms: Tcl1) | |
| Protein Name(s) | T-cell leukemia/lymphoma protein 1A
Oncogene TCL-1 Oncogene TCL1 Protein p14 TCL1 | |
| External Links | ||
| UniProt | P56280 | |
| EMBL | AF031956 Y15376 BC052336 | |
| CCDS | CCDS36549.1 | |
| RefSeq | NP_033363.1 | |
| UniGene | Mm.18154 | |
| PDB | 1JNP | |
| PDBsum | 1JNP | |
| ProteinModelPortal | P56280 | |
| SMR | P56280 | |
| BioGrid | 204023 | |
| STRING | 10090.ENSMUSP00000036066 | |
| iPTMnet | P56280 | |
| PhosphoSitePlus | P56280 | |
| REPRODUCTION-2DPAGE | P56280 | |
| PaxDb | P56280 | |
| PRIDE | P56280 | |
| Ensembl | ENSMUST00000041316 | |
| GeneID | 21432 | |
| KEGG | mmu:21432 | |
| UCSC | uc007oyd.2 | |
| CTD | 21432 | |
| MGI | MGI:1097166 | |
| eggNOG | ENOG410JEFE ENOG4111B9D | |
| GeneTree | ENSGT00390000006885 | |
| HOGENOM | HOG000037945 | |
| HOVERGEN | HBG052523 | |
| InParanoid | P56280 | |
| KO | K10167 | |
| PhylomeDB | P56280 | |
| TreeFam | TF337903 | |
| EvolutionaryTrace | P56280 | |
| PRO | PR:P56280 | |
| Proteomes | UP000000589 | |
| Bgee | ENSMUSG00000041359 | |
| CleanEx | MM_TCL1 | |
| ExpressionAtlas | P56280 | |
| Genevisible | P56280 | |
| GO | GO:0005938 GO:0005783 GO:0005634 GO:0045120 GO:0042802 GO:0010629 GO:2000036 GO:0019827 | |
| Gene3D | 2.40.15.10 | |
| InterPro | IPR004832 | |
| Pfam | PF01840 | |
| ProDom | PD015575 | |
| SUPFAM | SSF50904 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0032148 |
activation of protein kinase B activity |
ECO:0000315 |
P |
MOUSE TCL1A (TCL1) // As shown in Figures 5A and 5B, we found that an active form of AKT, phosphorylated at Ser473, is increased in iPSCs(High-K) or when exogenous TCL1 was expressed in iPSCs(Low-K), suggesting that KLF4-induced TCL1 enhances the AKT activity. |
complete | |||||
| GO:0090324 |
negative regulation of oxidative phosphorylation |
ECO:0000315 |
P |
MOUSE TCL1A (TCL1) // TCL1 decreases oxidative phosphorylation by antagonizing PnPase (Fig. 7G). |
complete | |||||
| GO:0045821 |
positive regulation of glycolytic process |
ECO:0000315 |
P |
the media of iPSCs(High-K) turned yellow faster than that of iPSCs(Low-K) (Figure 6B). This often indicates lactic acidosis resulting from enhanced glycolysis. Both glucose uptake and lactate production were higher in iPSCs(High-K) than in iPSCs(Low-K) (Figures 6C and 6D). KLF4 enhances glycolysis during the transition from iPSCs(Low-K) to iPSCs(High-K), in large part through the TCL1-AKT pathway. P: (TCL1) O: Mouse TCL1A (TCL 1) |
complete | |||||
| GO:0008283 |
cell proliferation |
ECO:0000315 |
P |
Although the AKT pathway is involved in cell proliferation and survival (Manning and Cantley, 2007), iPSCs(Low-K) and iPSCs(High-K), which differ in AKT activity (Figures 5A and 5B), showed unexpectedly similar rates of cell proliferation (Figure 6A), by author. Mouse TCL1A (TCL 1) EC: IMP |
complete | |||||
|
enables |
GO:0043539 |
protein serine/threonine kinase activator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000362401 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000362401 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000362401 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000362401 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000362401 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:2000036 |
regulation of stem cell population maintenance |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2446210 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0071902 |
positive regulation of protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0070207 |
protein homotrimerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045120 |
pronucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043539 |
protein serine/threonine kinase activator activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0033138 |
positive regulation of peptidyl-serine phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032461 |
positive regulation of protein oligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019827 |
stem cell population maintenance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010918 |
positive regulation of mitochondrial membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010629 |
negative regulation of gene expression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005938 |
cell cortex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043231 |
intracellular membrane-bounded organelle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Nishimura, K et al. (2017) A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation. Stem Cell Reports 8 787-801 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Loh, YH et al. (2007) Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 21 2545-57 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Narducci, MG et al. (2002) TCL1 participates in early embryonic development and is overexpressed in human seminomas. Proc. Natl. Acad. Sci. U.S.A. 99 11712-7 PubMed GONUTS page
- ↑ Ivanova, N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature 442 533-8 PubMed GONUTS page
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- GO:0032461 ! positive regulation of protein oligomerization
- GO:0071902 ! positive regulation of protein serine/threonine kinase activity
- GO:0010918 ! positive regulation of mitochondrial membrane potential
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0033138 ! positive regulation of peptidyl-serine phosphorylation
- GO:0045821 ! positive regulation of glycolytic process
- GO:0045120 ! pronucleus
- GO:0032991 ! protein-containing complex
- GO:0070207 ! protein homotrimerization
- GO:0019901 ! protein kinase binding
- GO:0043539 ! protein serine/threonine kinase activator activity
