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MOUSE:SUN2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sun2 (synonyms: Unc84b)
Protein Name(s) SUN domain-containing protein 2

Protein unc-84 homolog B Sad1/unc-84 protein-like 2

External Links
UniProt Q8BJS4
EMBL AY682987
AK128958
AK080116
AK156246
AK171058
CH466550
CCDS CCDS27649.1
CCDS56992.1
CCDS56993.1
RefSeq NP_001192274.1
NP_001192275.1
NP_919323.2
UniGene Mm.202715
PDB 5ED8
5ED9
PDBsum 5ED8
5ED9
ProteinModelPortal Q8BJS4
SMR Q8BJS4
BioGrid 230179
IntAct Q8BJS4
STRING 10090.ENSMUSP00000047864
iPTMnet Q8BJS4
PhosphoSite Q8BJS4
EPD Q8BJS4
MaxQB Q8BJS4
PaxDb Q8BJS4
PRIDE Q8BJS4
Ensembl ENSMUST00000046259
ENSMUST00000089311
ENSMUST00000100439
GeneID 223697
KEGG mmu:223697
UCSC uc007wuh.3
uc007wui.3
uc011zwc.2
CTD 25777
MGI MGI:2443011
eggNOG KOG2687
ENOG410YM6S
GeneTree ENSGT00390000011587
HOGENOM HOG000253025
HOVERGEN HBG056957
InParanoid Q8BJS4
KO K19347
OMA EHQQDSE
OrthoDB EOG7J446H
PhylomeDB Q8BJS4
TreeFam TF323915
Reactome R-MMU-1221633
NextBio 376830
PRO PR:Q8BJS4
Proteomes UP000000589
Bgee Q8BJS4
CleanEx MM_UNC84B
ExpressionAtlas Q8BJS4
Genevisible Q8BJS4
GO GO:0000794
GO:0010008
GO:0005639
GO:0034993
GO:0000784
GO:0005635
GO:0005637
GO:0031965
GO:0042802
GO:0005521
GO:0043495
GO:0051642
GO:0090286
GO:0006998
GO:0090292
GO:0031022
GO:0030335
InterPro IPR030272
IPR012919
PANTHER PTHR12911:SF22
Pfam PF07738
PROSITE PS51469

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051642

centrosome localization

PMID:19874786[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0021817

nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration

PMID:19874786[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051642

centrosome localization

PMID:20724637[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031022

nuclear migration along microfilament

PMID:20724637[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:20724637[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005637

nuclear inner membrane

PMID:19933576[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0090286

cytoskeletal anchoring at nuclear membrane

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000985481
UniProtKB:O94901
UniProtKB:Q9UH99

P

Seeded From UniProt

complete

enables

GO:0043495

protein membrane anchor

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000308195
TAIR:locus:2103182
TAIR:locus:2175354

F

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3041199
PANTHER:PTN000985495
UniProtKB:Q9UH99

C

Seeded From UniProt

complete

involved_in

GO:0006998

nuclear envelope organization

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000308195
UniProtKB:O94901
UniProtKB:Q9UH99

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1924303
MGI:MGI:2443011
PANTHER:PTN000308195
SGD:S000003556
TAIR:locus:2103182
TAIR:locus:2175354
UniProtKB:O94901
UniProtKB:Q9UH99
WB:WBGene00006311
WB:WBGene00006816
dictyBase:DDB_G0272869

C

Seeded From UniProt

complete

part_of

GO:0000794

condensed nuclear chromosome

PMID:17452644[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17972)
  • part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0000784

nuclear chromosome, telomeric region

PMID:17452644[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17972)
  • part_of:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090292

nuclear matrix anchoring at nuclear membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090286

cytoskeletal anchoring at nuclear membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

F

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006998

nuclear envelope organization

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

PMID:17452644[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:17972)
  • part_of:(CL:0000017)

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

C

Seeded From UniProt

complete

enables

GO:0005521

lamin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9UH99

F

Seeded From UniProt

complete

involved_in

GO:0090292

nuclear matrix anchoring at nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

P

Seeded From UniProt

complete

involved_in

GO:0090286

cytoskeletal anchoring at nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

F

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

C

Seeded From UniProt

complete

part_of

GO:0031965

nuclear membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

C

Seeded From UniProt

complete

involved_in

GO:0006998

nuclear envelope organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

P

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

C

Seeded From UniProt

complete

enables

GO:0005521

lamin binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9UH99
ensembl:ENSP00000385616

F

Seeded From UniProt

complete

part_of

GO:0005639

integral component of nuclear inner membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030272

C

Seeded From UniProt

complete

part_of

GO:0034993

meiotic nuclear membrane microtubule tethering complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR030272

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26688217[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q8BJS4-3

F

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

Reactome:R-MMU-912355

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051321

meiotic cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0469

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005768

endosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0967

C

Seeded From UniProt

complete

part_of

GO:0010008

endosome membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0100

C

Seeded From UniProt

complete

part_of

GO:0005637

nuclear inner membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0179

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0178

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Zhang, X et al. (2009) SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron 64 173-87 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Luxton, GW et al. (2010) Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science 329 956-9 PubMed GONUTS page
  3. ↑ Haque, F et al. (2010) Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J. Biol. Chem. 285 3487-98 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Schmitt, J et al. (2007) Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope. Proc. Natl. Acad. Sci. U.S.A. 104 7426-31 PubMed GONUTS page
  6. ↑ Nie, S et al. (2016) Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. Structure 24 80-91 PubMed GONUTS page
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