MOUSE:STING

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tmem173 (synonyms: Eris Mita, Mpys, Sting)
Protein Name(s)	Stimulator of interferon genes protein mSTING Endoplasmic reticulum interferon stimulator ERIS Mediator of IRF3 activation MMITA Transmembrane protein 173
External Links
UniProt	Q3TBT3
EMBL	FJ222242 DQ910493 AK012006 AK077788 AK089405 AK146284 AK153868 AK157370 AK158458 AK170724 AK171065 AK171203 AK171612 CH466557 BC027757 BC046640
CCDS	CCDS50253.1
RefSeq	NP_001276520.1 NP_001276521.1 NP_082537.1
UniGene	Mm.45995
PDB	4JC5 4KBY 4KC0 4LOJ 4LOK 4LOL
PDBsum	4JC5 4KBY 4KC0 4LOJ 4LOK 4LOL
ProteinModelPortal	Q3TBT3
SMR	Q3TBT3
BioGrid	215410
DIP	DIP-59959N
IntAct	Q3TBT3
STRING	10090.ENSMUSP00000111393
PhosphoSite	Q3TBT3
MaxQB	Q3TBT3
PaxDb	Q3TBT3
PRIDE	Q3TBT3
Ensembl	ENSMUST00000115728
GeneID	72512
KEGG	mmu:72512
UCSC	uc008emt.3 uc008emu.3 uc008emv.3
CTD	340061
MGI	MGI:1919762
eggNOG	NOG43926
GeneTree	ENSGT00390000008582
HOVERGEN	HBG094065
InParanoid	Q3TBT3
KO	K12654
OMA	TWMLALL
OrthoDB	EOG79GT88
PhylomeDB	Q3TBT3
TreeFam	TF324444
Reactome	R-MMU-1606341 R-MMU-1834941 R-MMU-3134975 R-MMU-3249367 R-MMU-3270619
NextBio	336376
PRO	PR:Q3TBT3
Proteomes	UP000000589
Bgee	Q3TBT3
CleanEx	MM_TMEM173
Genevisible	Q3TBT3
GO	GO:0005783 GO:0005789 GO:0005794 GO:0016021 GO:0005741 GO:0048471 GO:0005777 GO:0005886 GO:0035438 GO:0061507 GO:0042802 GO:0042803 GO:0019901 GO:0008134 GO:0031625 GO:0002218 GO:0006915 GO:0071360 GO:0035458 GO:0051607 GO:0045087 GO:0032608 GO:0002230 GO:0032092 GO:0033160 GO:0042993 GO:0045944 GO:0032481
InterPro	IPR029158
Pfam	PF15009

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:30568238^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	PMID:30568238^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061709	reticulophagy	PMID:29056340^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005776	autophagosome	PMID:29056340^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:26669264^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	PMID:26669264^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:26669264^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24560620^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:26300263^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:26300263^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:23258412^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:19776740^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:19776740^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19776740^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19433799^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:21947006^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:19776740^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:19433799^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21074459^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q80VI1	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:19776740^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WV6	C		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:23258412^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:21947006^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071360	cellular response to exogenous dsRNA	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 RGD:1562552 UniProtKB:A7SLZ2 UniProtKB:Q86WV6	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0039528	cytoplasmic pattern recognition receptor signaling pathway in response to virus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 ZFIN:ZDB-GENE-120921-1	P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:A7SLZ2 UniProtKB:Q86WV6	F		Seeded From UniProt	complete
involved_in	GO:0032608	interferon-beta production	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 RGD:1562552 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919762 PANTHER:PTN002154029 UniProtKB:Q86WV6	C		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002154029 UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562552	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071360	cellular response to exogenous dsRNA	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562552	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:21892174^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:28069950^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21892174^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:107657)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035458	cellular response to interferon-beta	PMID:21892174^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032608	interferon-beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032481	positive regulation of type I interferon production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032481	positive regulation of type I interferon production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562552	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031323	regulation of cellular metabolic process	PMID:28069950^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328317	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:23160154^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1328317 MGI:MGI:1859179 MGI:MGI:1859212 MGI:MGI:1929658	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	F		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19926846^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:21892174^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:19926846^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005777	peroxisome	PMID:22745163^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002218	activation of innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WV6	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M391 ensembl:ENSRNOP00000063348	P		Seeded From UniProt	complete
enables	GO:0061507	cyclic-GMP-AMP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M391 ensembl:ENSRNOP00000063348	F		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M391 ensembl:ENSRNOP00000063348	P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029158	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029158	P		Seeded From UniProt	complete
enables	GO:0035438	cyclic-di-GMP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033952	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0198	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page
↑ ^2.0 ^2.1 Moretti, J et al. (2017) STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell 171 809-823.e13 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page
↑ Zhang, L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40 329-41 PubMed GONUTS page
↑ ^5.0 ^5.1 Kranzusch, PJ et al. (2015) Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol. Cell 59 891-903 PubMed GONUTS page
↑ ^6.0 ^6.1 Wu, J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339 826-30 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ishikawa, H et al. (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461 788-92 PubMed GONUTS page
↑ ^8.0 ^8.1 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Burdette, DL et al. (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515-8 PubMed GONUTS page
↑ Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Zhang, Z et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12 959-65 PubMed GONUTS page
↑ ^13.0 ^13.1 Hasan, M et al. (2017) Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. Proc. Natl. Acad. Sci. U.S.A. 114 746-751 PubMed GONUTS page
↑ Hasan, M et al. (2013) Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat. Immunol. 14 61-71 PubMed GONUTS page
↑ ^15.0 ^15.1 Saitoh, T et al. (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc. Natl. Acad. Sci. U.S.A. 106 20842-6 PubMed GONUTS page
↑ Li, Y et al. (2012) LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc. Natl. Acad. Sci. U.S.A. 109 11770-5 PubMed GONUTS page

[PMID:30568238-1] 1.0 ^1.1 Liu, D et al. (2018) STING directly activates autophagy to tune the innate immune response. Cell Death Differ. PubMed GONUTS page

[PMID:29056340-2] 2.0 ^2.1 Moretti, J et al. (2017) STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell 171 809-823.e13 PubMed GONUTS page

[PMID:26669264-3] 3.0 ^3.1 ^3.2 Zhang, H et al. (2015) Rat and human STINGs profile similarly towards anticancer/antiviral compounds. Sci Rep 5 18035 PubMed GONUTS page

[PMID:24560620-4] Zhang, L et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40 329-41 PubMed GONUTS page

[PMID:26300263-5] 5.0 ^5.1 Kranzusch, PJ et al. (2015) Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol. Cell 59 891-903 PubMed GONUTS page

[PMID:23258412-6] 6.0 ^6.1 Wu, J et al. (2013) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339 826-30 PubMed GONUTS page

[PMID:19776740-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Ishikawa, H et al. (2009) STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 461 788-92 PubMed GONUTS page

[PMID:19433799-8] 8.0 ^8.1 Sun, W et al. (2009) ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc. Natl. Acad. Sci. U.S.A. 106 8653-8 PubMed GONUTS page

[PMID:21947006-9] 9.0 ^9.1 Burdette, DL et al. (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478 515-8 PubMed GONUTS page

[PMID:21074459-10] Tsuchida, T et al. (2010) The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. Immunity 33 765-76 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21892174-12] 12.0 ^12.1 ^12.2 ^12.3 Zhang, Z et al. (2011) The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells. Nat. Immunol. 12 959-65 PubMed GONUTS page

[PMID:28069950-13] 13.0 ^13.1 Hasan, M et al. (2017) Chronic innate immune activation of TBK1 suppresses mTORC1 activity and dysregulates cellular metabolism. Proc. Natl. Acad. Sci. U.S.A. 114 746-751 PubMed GONUTS page

[PMID:23160154-14] Hasan, M et al. (2013) Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes. Nat. Immunol. 14 61-71 PubMed GONUTS page

[PMID:19926846-15] 15.0 ^15.1 Saitoh, T et al. (2009) Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc. Natl. Acad. Sci. U.S.A. 106 20842-6 PubMed GONUTS page

[PMID:22745163-16] Li, Y et al. (2012) LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc. Natl. Acad. Sci. U.S.A. 109 11770-5 PubMed GONUTS page

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MOUSE:STING

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