MOUSE:SRGN

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Srgn (synonyms: Prg, Prg1)
Protein Name(s)	Serglycin Mastocytoma proteoglycan core protein Secretory granule proteoglycan core protein gp600
External Links
UniProt	P13609
EMBL	X16133 M27393 M27391 M27392 J04549 M33499 M34603 AK087960 AK151357 AK157945 BC037076
CCDS	CCDS23889.1
PIR	JQ0791
RefSeq	NP_035287.1 XP_006513438.1 XP_006513439.1 XP_006513440.1
UniGene	Mm.338790
ProteinModelPortal	P13609
BioGrid	202359
IntAct	P13609
PaxDb	P13609
PRIDE	P13609
Ensembl	ENSMUST00000020271 ENSMUST00000160987 ENSMUST00000162161
GeneID	19073
KEGG	mmu:19073
UCSC	uc007fhi.1
CTD	5552
MGI	MGI:97756
eggNOG	NOG44969
GeneTree	ENSGT00390000000885
HOGENOM	HOG000154415
HOVERGEN	HBG008180
InParanoid	P13609
KO	K06849
OMA	SNSANCI
OrthoDB	EOG7J9VS0
PhylomeDB	P13609
TreeFam	TF336310
NextBio	295598
PRO	PR:P13609
Proteomes	UP000000589
Bgee	P13609
CleanEx	MM_SRGN
ExpressionAtlas	P13609
Genevestigator	P13609
GO	GO:0005615 GO:0005794 GO:0000139 GO:0042629 GO:0042588 GO:0031214 GO:0008626 GO:0033382 GO:0033373 GO:0033364 GO:0030502 GO:0050710 GO:0016485 GO:0033371
InterPro	IPR007455
Pfam	PF04360

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033024	mast cell apoptosis	PMID:21123167^[1]	ECO:0000314			P		Figure 3.	complete CACAO 4125
involved_in	GO:0050710	negative regulation of cytokine secretion	PMID:16807245^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	PMID:15231821^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0033382	maintenance of granzyme B location in T cell secretory granule	PMID:16046402^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033373	maintenance of protease location in mast cell secretory granule	PMID:17010166^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033371	T cell secretory granule organization	PMID:16046402^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033364	mast cell secretory granule organization	PMID:15231821^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10124	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	PMID:17081126^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008626	granzyme-mediated apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10124	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10124	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10124	C		Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0099175	regulation of postsynapse organization	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0099091	postsynaptic specialization, intracellular component	PMID:19766573^[8]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(GO:0098685) part_of:(UBERON:0000061)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19766573^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19766573^[8]	ECO:0006003	electron microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19766573^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:19766573^[8]	ECO:0000279	western blot evidence used in manual assertion		C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19766573^[8]	ECO:0006042	cell fractionation evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19766573^[8]	ECO:0006003	electron microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19766573^[8]	ECO:0005589	confocal microscopy evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	PMID:19766573^[8]	ECO:0000279	western blot evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:27453502^[7]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:27453502^[7]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098685) occurs_in:(UBERON:0000061)	Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000425257 UniProtKB:P10124	P		Seeded From UniProt	complete
part_of	GO:0042588	zymogen granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619969	C		Seeded From UniProt	complete
enables	GO:0005518	collagen binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619969	F		Seeded From UniProt	complete
colocalizes_with	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619969	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0031214	biomineral tissue development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0091	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Melo, FR et al. (2011) A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J. Biol. Chem. 286 5423-33 PubMed GONUTS page
↑ Zernichow, L et al. (2006) Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J. Biol. Chem. 281 26792-801 PubMed GONUTS page
↑ ^3.0 ^3.1 Abrink, M et al. (2004) Serglycin is essential for maturation of mast cell secretory granule. J. Biol. Chem. 279 40897-905 PubMed GONUTS page
↑ ^4.0 ^4.1 Grujic, M et al. (2005) Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J. Biol. Chem. 280 33411-8 PubMed GONUTS page
↑ Henningsson, F et al. (2006) A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J. 273 4901-12 PubMed GONUTS page
↑ Lundequist, A et al. () Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol. Chem. 387 1513-9 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Liu, X et al. (2016) PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Dev. Cell 38 275-90 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 Trimbuch, T et al. (2009) Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 138 1222-35 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21123167-1] Melo, FR et al. (2011) A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway. J. Biol. Chem. 286 5423-33 PubMed GONUTS page

[PMID:16807245-2] Zernichow, L et al. (2006) Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide. J. Biol. Chem. 281 26792-801 PubMed GONUTS page

[PMID:15231821-3] 3.0 ^3.1 Abrink, M et al. (2004) Serglycin is essential for maturation of mast cell secretory granule. J. Biol. Chem. 279 40897-905 PubMed GONUTS page

[PMID:16046402-4] 4.0 ^4.1 Grujic, M et al. (2005) Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage. J. Biol. Chem. 280 33411-8 PubMed GONUTS page

[PMID:17010166-5] Henningsson, F et al. (2006) A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components. FEBS J. 273 4901-12 PubMed GONUTS page

[PMID:17081126-6] Lundequist, A et al. () Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases. Biol. Chem. 387 1513-9 PubMed GONUTS page

[PMID:27453502-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 Liu, X et al. (2016) PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. Dev. Cell 38 275-90 PubMed GONUTS page

[PMID:19766573-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 Trimbuch, T et al. (2009) Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 138 1222-35 PubMed GONUTS page

[PMID:21873635-9] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:SRGN

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