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MOUSE:SODC

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Sod1
Protein Name(s) Superoxide dismutase [Cu-Zn]
External Links
UniProt P08228
EMBL X06683
M60798
M60794
M60795
M60796
M60797
M35725
AK020624
AK077284
BC002066
BC048874
BC086886
CCDS CCDS37395.1
PIR JQ0915
RefSeq NP_035564.1
UniGene Mm.276325
Mm.466779
PDB 3GTT
3GTV
3LTV
PDBsum 3GTT
3GTV
3LTV
ProteinModelPortal P08228
SMR P08228
BioGrid 203387
DIP DIP-48691N
IntAct P08228
MINT MINT-1869618
STRING 10090.ENSMUSP00000023707
PhosphoSite P08228
DOSAC-COBS-2DPAGE P08228
REPRODUCTION-2DPAGE IPI00130589
P08228
SWISS-2DPAGE P08228
UCD-2DPAGE P08228
MaxQB P08228
PaxDb P08228
PRIDE P08228
Ensembl ENSMUST00000023707
GeneID 20655
KEGG mmu:20655
UCSC uc007zvz.1
CTD 6647
MGI MGI:98351
eggNOG COG2032
GeneTree ENSGT00530000063226
HOGENOM HOG000263447
HOVERGEN HBG000062
InParanoid P08228
KO K04565
OMA NDPNAKR
OrthoDB EOG776SR4
PhylomeDB P08228
TreeFam TF105131
Reactome REACT_189141
ChiTaRS Sod1
EvolutionaryTrace P08228
NextBio 299081
PRO PR:P08228
Proteomes UP000000589
Bgee P08228
CleanEx MM_SOD1
Genevestigator P08228
GO GO:0005737
GO:0031410
GO:0005829
GO:0032839
GO:0031045
GO:0031012
GO:0005615
GO:0070062
GO:0005758
GO:0005739
GO:0043025
GO:0005634
GO:0005777
GO:0005886
GO:0043234
GO:0051087
GO:0005507
GO:0030346
GO:0004784
GO:0008270
GO:0000187
GO:0007568
GO:0008089
GO:0060088
GO:0007569
GO:0006879
GO:0071318
GO:0071276
GO:0035865
GO:0007566
GO:0006749
GO:0060047
GO:0050665
GO:0007626
GO:0046716
GO:0002262
GO:0043066
GO:0045541
GO:0043524
GO:0060052
GO:0001541
GO:0032287
GO:0043085
GO:0001819
GO:1902177
GO:0032930
GO:0072593
GO:0008217
GO:0051881
GO:0040014
GO:0045859
GO:0032314
GO:0060087
GO:0019430
GO:0001975
GO:0046677
GO:0097332
GO:0048678
GO:0034465
GO:0046688
GO:0042493
GO:0045471
GO:0009408
GO:0042542
GO:0031667
GO:0010033
GO:0006979
GO:0000302
GO:0000303
GO:0001895
GO:0008090
GO:0007605
GO:0007283
GO:0042554
GO:0006801
GO:0019226
Gene3D 2.60.40.200
InterPro IPR018152
IPR001424
Pfam PF00080
PRINTS PR00068
SUPFAM SSF49329
PROSITE PS00087
PS00332

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0050728

negative regulation of inflammatory response

PMID:25381879[1]

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS0000021B51_10090

P

occurs_in:(CL:0000576)

Seeded From UniProt

complete

involved_in

GO:0050766

positive regulation of phagocytosis

PMID:25381879[1]

ECO:0000316

genetic interaction evidence used in manual assertion

RNAcentral:URS0000021B51_10090

P

has_agent:(CL:0000129)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:24006456[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

produced_by:(CL:0002548)

Seeded From UniProt

complete

part_of

GO:0043209

myelin sheath

PMID:17634366[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000128)

Seeded From UniProt

complete

involved_in

GO:0008090

retrograde axonal transport

PMID:20510358[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008089

anterograde axonal transport

PMID:20510358[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

involved_in

GO:0045541

negative regulation of cholesterol biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0032839

dendrite cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

enables

GO:0030346

protein phosphatase 2B binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

involved_in

GO:0001819

positive regulation of cytokine production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

involved_in

GO:0019430

removal of superoxide radicals

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0033631
MGI:MGI:98351
PANTHER:PTN000000113
PomBase:SPAC22E12.04
RGD:3731
UniProtKB:P00442
WB:WBGene00004930

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002467128
UniProtKB:P00441
WB:WBGene00004930

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002558032
RGD:3731
UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002467128
RGD:3731
UniProtKB:P00441

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13419
PANTHER:PTN000000113
RGD:3731
UniProtKB:O14618
UniProtKB:P00441
UniProtKB:P00442
WB:WBGene00004930

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13419
FB:FBgn0003462
FB:FBgn0033631
MGI:MGI:103181
MGI:MGI:98351
PANTHER:PTN000000113
PomBase:SPAC821.10c
RGD:3731
RGD:3733
SGD:S000003865
TAIR:locus:2025595
TAIR:locus:2046168
UniProtKB:P00441
UniProtKB:P00442
UniProtKB:P9WGE9
WB:WBGene00004930
WB:WBGene00004933
dictyBase:DDB_G0267420
dictyBase:DDB_G0282993

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060088

auditory receptor cell stereocilium organization

PMID:10466888[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

  • occurs_in:(EMAPA:17597)
  • occurs_in:(CL:0000202)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060088

auditory receptor cell stereocilium organization

PMID:10464373[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

  • occurs_in:(EMAPA:16193)
  • occurs_in:(CL:0000202)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060087

relaxation of vascular smooth muscle

PMID:14679182[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

occurs_in:(EMAPA:17312)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060087

relaxation of vascular smooth muscle

PMID:12433839[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

occurs_in:(EMAPA:18609)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060052

neurofilament cytoskeleton organization

PMID:11343650[10]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97313

P

  • occurs_in:(EMAPA:35794)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060052

neurofilament cytoskeleton organization

PMID:11343650[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3574016

P

  • occurs_in:(EMAPA:35794)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060047

heart contraction

PMID:10679476[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387861

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060047

heart contraction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050665

hydrogen peroxide biosynthetic process

PMID:14679182[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

  • occurs_in:(EMAPA:17312)
  • occurs_in:(CL:0000115)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050665

hydrogen peroxide biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050665

hydrogen peroxide biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048678

response to axon injury

PMID:8673102[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

enables

GO:0048365

Rac GTPase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046716

muscle cell cellular homeostasis

PMID:16716900[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2680903

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046688

response to copper ion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045859

regulation of protein kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045541

negative regulation of cholesterol biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045471

response to ethanol

PMID:17448893[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:10464373[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043087

regulation of GTPase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043085

positive regulation of catalytic activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043085

positive regulation of catalytic activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:16036348[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

  • regulates_o_occurs_in:(EMAPA:17972)
  • regulates_o_occurs_in:(CL:0000017)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:12223545[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042554

superoxide anion generation

PMID:15317809[17]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042542

response to hydrogen peroxide

PMID:15642323[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

has_participant:(EMAPA:17838)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042493

response to drug

PMID:16831125[19]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

  • occurs_in:(EMAPA:35800)
  • occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0040014

regulation of multicellular organism growth

PMID:16377630[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

part_of

GO:0032839

dendrite cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032287

peripheral nervous system myelin maintenance

PMID:10433959[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031667

response to nutrient levels

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0031045

dense core granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

enables

GO:0030346

protein phosphatase 2B binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

enables

GO:0030346

protein phosphatase 2B binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

F

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:11493445[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95480

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:9788901[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:9516486[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:8673102[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:17448893[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:12433839[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:11493445[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:10679476[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387861

P

has_participant:(EMAPA:16105)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:10471451[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:10436316[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019226

transmission of nerve impulse

PMID:10433959[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010033

response to organic substance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009408

response to heat

PMID:16942767[27]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008217

regulation of blood pressure

PMID:12433839[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007626

locomotory behavior

PMID:10433959[21]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:16055286[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:10464373[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007605

sensory perception of sound

PMID:10436316[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007569

cell aging

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007568

aging

PMID:16377630[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007566

embryo implantation

PMID:9516486[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:16036348[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:17059387[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:16716900[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2680903

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

PMID:12223545[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006879

cellular iron ion homeostasis

PMID:16377630[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006801

superoxide metabolic process

PMID:11404260[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006801

superoxide metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006801

superoxide metabolic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006749

glutathione metabolic process

PMID:16377630[20]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

occurs_in:(EMAPA:16846)

Seeded From UniProt

complete

colocalizes_with

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[31]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14651853[32]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)|part_of:(EMAPA:16105)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18809582[33]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000008

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:15634772[34]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:9788901[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:9516486[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:8673102[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:16716900[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2680903

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:14679182[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:12433839[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:11404260[30]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:10679476[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387861

F

occurs_in:(EMAPA:16105)

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:10471451[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

F

occurs_in:(EMAPA:16332)

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:10436316[26]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:7444718[35]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:291939[36]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:15317809[17]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:12968068[37]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:12646716[38]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3731

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002262

myeloid cell homeostasis

PMID:11493445[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95480

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002262

myeloid cell homeostasis

PMID:11493445[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857872

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001895

retina homeostasis

PMID:16844785[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001819

positive regulation of cytokine production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:9724058[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

results_in_development_of:(EMAPA:17962)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000303

response to superoxide

PMID:9788901[23]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000303

response to superoxide

PMID:9516486[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3526701

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000303

response to superoxide

PMID:16357131[41]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2680903

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000303

response to superoxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P00441

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000302

response to reactive oxygen species

PMID:17059387[29]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857873

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000187

activation of MAPK activity

PMID:12223545[16]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:1904115

axon cytoplasm

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008089

C

Seeded From UniProt

complete

involved_in

GO:1902177

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0072593

reactive oxygen species metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0060047

heart contraction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0051881

regulation of mitochondrial membrane potential

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

involved_in

GO:0050665

hydrogen peroxide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

enables

GO:0048365

Rac GTPase binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

involved_in

GO:0045859

regulation of protein kinase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0045541

negative regulation of cholesterol biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0043087

regulation of GTPase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

involved_in

GO:0032930

positive regulation of superoxide anion generation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

part_of

GO:0032839

dendrite cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

enables

GO:0030346

protein phosphatase 2B binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

involved_in

GO:0010033

response to organic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

involved_in

GO:0007569

cell aging

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0006801

superoxide metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

F

Seeded From UniProt

complete

involved_in

GO:0001819

positive regulation of cytokine production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0000303

response to superoxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P00441
ensembl:ENSP00000270142

P

Seeded From UniProt

complete

involved_in

GO:0097332

response to antipsychotic drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0071318

cellular response to ATP

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0071276

cellular response to cadmium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0050665

hydrogen peroxide biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0046688

response to copper ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0046677

response to antibiotic

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0043085

positive regulation of catalytic activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

part_of

GO:0043025

neuronal cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

involved_in

GO:0035865

cellular response to potassium ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0034599

cellular response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0034465

response to carbon monoxide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

involved_in

GO:0031667

response to nutrient levels

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

part_of

GO:0031045

dense core granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

enables

GO:0030346

protein phosphatase 2B binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

F

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

F

Seeded From UniProt

complete

involved_in

GO:0019430

removal of superoxide radicals

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

involved_in

GO:0006801

superoxide metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

part_of

GO:0005777

peroxisome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005764

lysosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

F

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

F

Seeded From UniProt

complete

involved_in

GO:0001975

response to amphetamine

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P07632
ensembl:ENSRNOP00000002885

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC9
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:V9HWC9
ensembl:ENSP00000270142

C

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018152

F

Seeded From UniProt

complete

involved_in

GO:0006801

superoxide metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001424
InterPro:IPR036423

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001424
InterPro:IPR036423

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018152

P

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:1.15.1.1

F

Seeded From UniProt

complete

part_of

GO:0005758

mitochondrial intermembrane space

Reactome:R-MMU-3780963
Reactome:R-MMU-3780959

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019430

removal of superoxide radicals

PMID:11557311[42]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11557311[42]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004784

superoxide dismutase activity

PMID:12223545[16]
PMID:11557311[42]

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

enables

GO:0016209

antioxidant activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0049

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Butovsky, O et al. (2015) Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann. Neurol. 77 75-99 PubMed GONUTS page
  2. Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
  3. Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
  4. 4.0 4.1 Shi, P et al. (2010) Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport. Biochim. Biophys. Acta 1802 707-16 PubMed GONUTS page
  5. 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. McFadden, SL et al. () Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase. Neurobiol. Aging 20 1-8 PubMed GONUTS page
  7. 7.0 7.1 7.2 McFadden, SL et al. (1999) Cu/Zn SOD deficiency potentiates hearing loss and cochlear pathology in aged 129,CD-1 mice. J. Comp. Neurol. 413 101-12 PubMed GONUTS page
  8. 8.0 8.1 8.2 Morikawa, K et al. (2003) Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. J. Clin. Invest. 112 1871-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 Didion, SP et al. (2002) Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ. Res. 91 938-44 PubMed GONUTS page
  10. 10.0 10.1 Nguyen, MD et al. (2001) Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30 135-47 PubMed GONUTS page
  11. 11.0 11.1 11.2 Yoshida, T et al. (2000) Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. Circ. Res. 86 264-9 PubMed GONUTS page
  12. 12.0 12.1 12.2 Reaume, AG et al. (1996) Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet. 13 43-7 PubMed GONUTS page
  13. 13.0 13.1 13.2 Muller, FL et al. (2006) Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic. Biol. Med. 40 1993-2004 PubMed GONUTS page
  14. 14.0 14.1 Kessova, IG & Cederbaum, AI (2007) Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic. Biol. Med. 42 1470-80 PubMed GONUTS page
  15. 15.0 15.1 Ishii, T et al. (2005) Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress. Free Radic. Res. 39 697-705 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 Noshita, N et al. (2002) Copper/zinc superoxide dismutase attenuates neuronal cell death by preventing extracellular signal-regulated kinase activation after transient focal cerebral ischemia in mice. J. Neurosci. 22 7923-30 PubMed GONUTS page
  17. 17.0 17.1 Muller, FL et al. (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279 49064-73 PubMed GONUTS page
  18. Reddy, VN et al. (2004) Effects of variation in superoxide dismutases (SOD) on oxidative stress and apoptosis in lens epithelium. Exp. Eye Res. 79 859-68 PubMed GONUTS page
  19. Lei, XG et al. (2006) Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity. Biochem. J. 399 455-61 PubMed GONUTS page
  20. 20.0 20.1 20.2 20.3 Sentman, ML et al. (2006) Phenotypes of mice lacking extracellular superoxide dismutase and copper- and zinc-containing superoxide dismutase. J. Biol. Chem. 281 6904-9 PubMed GONUTS page
  21. 21.0 21.1 21.2 Flood, DG et al. (1999) Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions. Am. J. Pathol. 155 663-72 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 Hadjur, S et al. (2001) Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase. Blood 98 1003-11 PubMed GONUTS page
  23. 23.0 23.1 23.2 Ho, YS et al. (1998) The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ. Health Perspect. 106 Suppl 5 1219-28 PubMed GONUTS page
  24. 24.0 24.1 24.2 24.3 Ho, YS et al. (1998) Reduced fertility in female mice lacking copper-zinc superoxide dismutase. J. Biol. Chem. 273 7765-9 PubMed GONUTS page
  25. 25.0 25.1 Kawase, M et al. (1999) Exacerbation of delayed cell injury after transient global ischemia in mutant mice with CuZn superoxide dismutase deficiency. Stroke 30 1962-8 PubMed GONUTS page
  26. 26.0 26.1 26.2 Ohlemiller, KK et al. () Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss. Audiol. Neurootol. 4 237-46 PubMed GONUTS page
  27. Schmidt-Ott, KM et al. (2006) c-kit delineates a distinct domain of progenitors in the developing kidney. Dev. Biol. 299 238-49 PubMed GONUTS page
  28. Keithley, EM et al. (2005) Cu/Zn superoxide dismutase and age-related hearing loss. Hear. Res. 209 76-85 PubMed GONUTS page
  29. 29.0 29.1 Iuchi, Y et al. (2007) Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production. Biochem. J. 402 219-27 PubMed GONUTS page
  30. 30.0 30.1 Levy, MA et al. (2001) Cellular response of antioxidant metalloproteins in Cu/Zn SOD transgenic mice exposed to hyperoxia. Am. J. Physiol. Lung Cell Mol. Physiol. 281 L172-82 PubMed GONUTS page
  31. Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
  32. Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
  33. Maggi, LB Jr et al. (2008) Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome. Mol. Cell. Biol. 28 7050-65 PubMed GONUTS page
  34. Turner, BJ et al. (2005) Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis. J. Neurosci. 25 108-17 PubMed GONUTS page
  35. Schäfer, R et al. (1980) Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids. Somatic Cell Genet. 6 709-17 PubMed GONUTS page
  36. Francke, U & Taggart, RT (1979) Assignment of the gene for cytoplasmic superoxide dismutase (Sod-1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse. Proc. Natl. Acad. Sci. U.S.A. 76 5230-3 PubMed GONUTS page
  37. Prohaska, JR et al. (2003) Copper, zinc-superoxide dismutase protein but not mRNA is lower in copper-deficient mice and mice lacking the copper chaperone for superoxide dismutase. Exp. Biol. Med. (Maywood) 228 959-66 PubMed GONUTS page
  38. Khan, JY & Black, SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr. Res. 54 77-82 PubMed GONUTS page
  39. Imamura, Y et al. (2006) Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A. 103 11282-7 PubMed GONUTS page
  40. Matzuk, MM et al. (1998) Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology 139 4008-11 PubMed GONUTS page
  41. Busuttil, RA et al. (2005) Organ-specific increase in mutation accumulation and apoptosis rate in CuZn-superoxide dismutase-deficient mice. Cancer Res. 65 11271-5 PubMed GONUTS page
  42. 42.0 42.1 42.2 Behndig, A et al. (2001) In vitro photochemical cataract in mice lacking copper-zinc superoxide dismutase. Free Radic. Biol. Med. 31 738-44 PubMed GONUTS page