MOUSE:SOCS1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Socs1 (synonyms: Cish1, Ssi1)
Protein Name(s)	Suppressor of cytokine signaling 1 SOCS-1 JAK-binding protein JAB STAT-induced STAT inhibitor 1 SSI-1
External Links
UniProt	O35716
EMBL	U88325 AB000677 AB000710 AF120490 AF180302 AK028632 AK154706 BC132366 BC132368
CCDS	CCDS27952.1
RefSeq	NP_001258532.1 NP_034026.1
UniGene	Mm.130
ProteinModelPortal	O35716
SMR	O35716
BioGrid	198719
IntAct	O35716
MINT	MINT-84865
PRIDE	O35716
Ensembl	ENSMUST00000038099
GeneID	12703
KEGG	mmu:12703
UCSC	uc007yed.1
CTD	8651
MGI	MGI:1354910
eggNOG	NOG298538
GeneTree	ENSGT00760000119136
HOGENOM	HOG000236320
HOVERGEN	HBG002457
InParanoid	O35716
KO	K04694
OMA	ACGFYWG
OrthoDB	EOG7TMZSZ
PhylomeDB	O35716
TreeFam	TF321368
Reactome	REACT_198614 REACT_198622 REACT_198627 REACT_198645 REACT_198660 REACT_199115 REACT_227425 REACT_230045
SABIO-RK	O35716
UniPathway	UPA00143
NextBio	281962
PRO	PR:O35716
Proteomes	UP000000589
Bgee	O35716
CleanEx	MM_SOCS1
Genevestigator	O35716
GO	GO:0016023 GO:0005829 GO:0005634 GO:0019210 GO:0071230 GO:0019221 GO:0045444 GO:0007259 GO:0046627 GO:0046426 GO:0042518 GO:0016567 GO:0010534 GO:0050707 GO:0040008 GO:0060334 GO:0046425 GO:0001932 GO:0042510
Gene3D	3.30.505.10
InterPro	IPR000980 IPR028413 IPR028411 IPR001496
PANTHER	PTHR10385 PTHR10385:SF5
Pfam	PF00017 PF07525
SMART	SM00252 SM00253 SM00969
SUPFAM	SSF55550
PROSITE	PS50001 PS50225

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048589	developmental growth	PMID:9826711^[1]	ECO:0000315			P		Fig. 2	complete CACAO 3749
involved_in	GO:0043377	negative regulation of CD8-positive, alpha-beta T cell differentiation	PMID:24880459^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation	PMID:24880459^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 RGD:621042	F		Seeded From UniProt	complete
involved_in	GO:0046854	phosphatidylinositol phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0020622 PANTHER:PTN000806614 UniProtKB:P23727	P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1201791 MGI:MGI:1354910 PANTHER:PTN000043896	P		Seeded From UniProt	complete
part_of	GO:0005942	phosphatidylinositol 3-kinase complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109277 PANTHER:PTN000806614 RGD:3329 UniProtKB:P23727 WB:WBGene00000001	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071407	cellular response to organic cyclic compound	PMID:19414010^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9QX78	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	PMID:19414010^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9QX78	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050707	regulation of cytokine secretion	PMID:21606371^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2656917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:15169905^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	PMID:11371356^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2445448	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	PMID:21606371^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2656917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045591	positive regulation of regulatory T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:16127460^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	PMID:9202127^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	PMID:21606371^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2656917	P		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:11606785^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2177057	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:9202127^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:9202126^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019210	kinase inhibitor activity	PMID:9889194^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0019210	kinase inhibitor activity	PMID:9202126^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010533	regulation of activation of Janus kinase activity	PMID:21606371^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2656917	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:11854514^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	C		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15524	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001932	regulation of protein phosphorylation	PMID:15169905^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019210	P		Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019210	P		Seeded From UniProt	complete
involved_in	GO:0043551	regulation of phosphatidylinositol 3-kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0046935	P		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	P		Seeded From UniProt	complete
involved_in	GO:0045591	positive regulation of regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	P		Seeded From UniProt	complete
involved_in	GO:0042532	negative regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	P		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	C		Seeded From UniProt	complete
enables	GO:0005159	insulin-like growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15524 ensembl:ENSP00000496577	F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4JHT5 ensembl:ENSP00000496577	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4JHT5 ensembl:ENSP00000496577	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028411	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR036036	P		Seeded From UniProt	complete
involved_in	GO:0046426	negative regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028411	P		Seeded From UniProt	complete
involved_in	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028411	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-912695 Reactome:R-MMU-1524177 Reactome:R-MMU-1169194	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00143	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Starr, R et al. (1998) Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. U.S.A. 95 14395-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Luckey, MA et al. (2014) The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat. Immunol. 15 638-45 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Ueki, K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell. Biol. 24 5434-46 PubMed GONUTS page
↑ Naka, T et al. (2001) SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14 535-45 PubMed GONUTS page
↑ Banks, AS et al. (2005) Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J. Clin. Invest. 115 2462-71 PubMed GONUTS page
↑ ^10.0 ^10.1 Naka, T et al. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387 924-9 PubMed GONUTS page
↑ Zhang, JG et al. (2001) The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. U.S.A. 98 13261-5 PubMed GONUTS page
↑ ^12.0 ^12.1 Endo, TA et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 921-4 PubMed GONUTS page
↑ Nicholson, SE et al. (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18 375-85 PubMed GONUTS page
↑ Chen, XP et al. (2002) Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc. Natl. Acad. Sci. U.S.A. 99 2175-80 PubMed GONUTS page

[PMID:9826711-1] Starr, R et al. (1998) Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. Proc. Natl. Acad. Sci. U.S.A. 95 14395-9 PubMed GONUTS page

[PMID:24880459-2] 2.0 ^2.1 Luckey, MA et al. (2014) The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Nat. Immunol. 15 638-45 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19414010-4] 4.0 ^4.1 Lv, N et al. (2009) JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp. Cell Res. 315 2064-71 PubMed GONUTS page

[PMID:20548288-5] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:21606371-6] 6.0 ^6.1 ^6.2 ^6.3 Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page

[PMID:15169905-7] 7.0 ^7.1 Ueki, K et al. (2004) Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms. Mol. Cell. Biol. 24 5434-46 PubMed GONUTS page

[PMID:11371356-8] Naka, T et al. (2001) SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo. Immunity 14 535-45 PubMed GONUTS page

[PMID:16127460-9] Banks, AS et al. (2005) Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J. Clin. Invest. 115 2462-71 PubMed GONUTS page

[PMID:9202127-10] 10.0 ^10.1 Naka, T et al. (1997) Structure and function of a new STAT-induced STAT inhibitor. Nature 387 924-9 PubMed GONUTS page

[PMID:11606785-11] Zhang, JG et al. (2001) The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl. Acad. Sci. U.S.A. 98 13261-5 PubMed GONUTS page

[PMID:9202126-12] 12.0 ^12.1 Endo, TA et al. (1997) A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387 921-4 PubMed GONUTS page

[PMID:9889194-13] Nicholson, SE et al. (1999) Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18 375-85 PubMed GONUTS page

[PMID:11854514-14] Chen, XP et al. (2002) Pim serine/threonine kinases regulate the stability of Socs-1 protein. Proc. Natl. Acad. Sci. U.S.A. 99 2175-80 PubMed GONUTS page

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MOUSE:SOCS1

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References

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