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MOUSE:SNP23

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Snap23 (synonyms: Sndt)
Protein Name(s) Synaptosomal-associated protein 23

SNAP-23 Syndet Vesicle-membrane fusion protein SNAP-23

External Links
UniProt O09044
EMBL AB000822
U73143
AF007169
AF213257
AF213251
AF213252
AF213253
AF213254
AF213255
AF213256
AK019162
BC070456
CCDS CCDS16622.1
PIR JC5512
RefSeq NP_001171263.1
NP_001171264.1
NP_033248.1
XP_006499120.1
UniGene Mm.245715
ProteinModelPortal O09044
SMR O09044
BioGrid 203367
DIP DIP-41401N
IntAct O09044
MINT MINT-269238
PhosphoSite O09044
MaxQB O09044
PaxDb O09044
PRIDE O09044
Ensembl ENSMUST00000028743
ENSMUST00000110711
GeneID 20619
KEGG mmu:20619
UCSC uc008lwg.1
CTD 8773
MGI MGI:109356
eggNOG NOG259235
GeneTree ENSGT00390000012186
HOGENOM HOG000231599
HOVERGEN HBG056971
InParanoid O09044
KO K08508
OrthoDB EOG75F4F5
PhylomeDB O09044
Reactome REACT_199054
REACT_234979
NextBio 299005
PRO PR:O09044
Proteomes UP000000589
Bgee O09044
CleanEx MM_SNAP23
ExpressionAtlas O09044
Genevestigator O09044
GO GO:0030054
GO:0031410
GO:0043005
GO:0005886
GO:0045202
GO:0006887
GO:0015031
InterPro IPR000928
IPR000727
Pfam PF00835
PF05739
SMART SM00397
PROSITE PS50192

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0043009

chordate embryonic development

PMID:21479242[1]

ECO:0000315

P

To generate Snap23-deficient mice, Snap23Δ/wt mice were mated with each other. Snap23Δ/Δ pups were never obtained from adult heterozygous matings after more than 50 live births. Genotyping confirmed that approximately 2/3 of these offspring were Snap23Δ/wt and 1/3 were Snap23wt/wt, demonstrating that deletion of Snap23 leads to embryonic lethality.

complete

GO:0007566

embryo implantation

PMID:21479242[1]

ECO:0000315

P

Fig 4 and Table 2.

Blastocyst stage embryos were recovered by flushing from the uterus of pregnant mice at day E3.5. 5 among a total of 27 blastocysts isolated using this procedure appeared grossly abnormal and had not expanded properly, suggesting that these blastocysts were dying, and unlike the normal blastocysts, they failed to develop any further after 24 hrs of culture. Each of five small, degenerating blastocysts showed a Snap23Δ/Δ genotype, whereas the morphologically normal embryos included 11 SNAP23Δ/wt heterozygotes and 11 SNAP23wt/wt wild-type embryos.

complete

involved_in

GO:0031629

synaptic vesicle fusion to presynaptic active zone membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011288
PANTHER:PTN000447754

P

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011288
FB:FBgn0034913
MGI:MGI:109356
PANTHER:PTN000447753
RGD:3728
RGD:620221
SGD:S000003241
SGD:S000004619
UniProtKB:O00161
UniProtKB:O95721
UniProtKB:P60880

C

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000447753
RGD:620221
UniProtKB:O00161

F

Seeded From UniProt

complete

involved_in

GO:0016082

synaptic vesicle priming

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011288
PANTHER:PTN000447754

P

Seeded From UniProt

complete

involved_in

GO:0006906

vesicle fusion

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011288
PANTHER:PTN000447753
SGD:S000003241

P

Seeded From UniProt

complete

involved_in

GO:0006887

exocytosis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109356
PANTHER:PTN000447753
SGD:S000003241

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109356
PANTHER:PTN000447752
RGD:3728
RGD:620221
SGD:S000004619
TAIR:locus:2159426
UniProtKB:O00161
UniProtKB:Q17QQ3
WB:WBGene00004364
WB:WBGene00006454

C

Seeded From UniProt

complete

enables

GO:0005484

SNAP receptor activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011288
FB:FBgn0034913
PANTHER:PTN000447753
RGD:620221
SGD:S000003241

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099003

vesicle-mediated transport in synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

part_of

GO:0098982

GABA-ergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

C

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098967

exocytic insertion of neurotransmitter receptor to postsynaptic membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0065003

protein-containing complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061025

membrane fusion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

part_of

GO:0042582

azurophil granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0042581

specific granule

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

PMID:18505797[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

PMID:18535671[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35651)
  • part_of:(CL:0002064)
  • part_of:(GO:0042589)

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

PMID:18535671[4]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:35651)
  • part_of:(CL:0002064)
  • part_of:(GO:0005886)

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0031201

SNARE complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

C

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

F

Seeded From UniProt

complete

enables

GO:0019905

syntaxin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0017157

regulation of exocytosis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0016192

vesicle-mediated transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0015031

protein transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006887

exocytosis

PMID:18505797[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005913

cell-cell adherens junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:18505797[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

C

Seeded From UniProt

complete

enables

GO:0005484

SNAP receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620221

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002553

histamine secretion by mast cell

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O00161

P

Seeded From UniProt

complete

part_of

GO:0042629

mast cell granule

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0002553

C

Seeded From UniProt

complete

part_of

GO:0098793

presynapse

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0031629

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-MMU-1449573

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0771
UniProtKB-SubCell:SL-0261

C

Seeded From UniProt

complete

involved_in

GO:0015031

protein transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0653

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0045202

synapse

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0770

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Suh, YH et al. (2011) Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice. PLoS ONE 6 e18444 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Procino, G et al. (2008) AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. J. Cell. Sci. 121 2097-106 PubMed GONUTS page
  4. ↑ 4.0 4.1 Cosen-Binker, LI et al. (2008) VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. J. Clin. Invest. 118 2535-51 PubMed GONUTS page
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