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MOUSE:SIR6
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Sirt6 (synonyms: Sir2l6) | |
| Protein Name(s) | NAD-dependent protein deacetylase sirtuin-6
Regulatory protein SIR2 homolog 6 SIR2-like protein 6 | |
| External Links | ||
| UniProt | P59941 | |
| EMBL | BC052763 | |
| CCDS | CCDS24066.1 | |
| RefSeq | NP_853617.1 | |
| UniGene | Mm.131825 Mm.25643 | |
| ProteinModelPortal | P59941 | |
| SMR | P59941 | |
| BioGrid | 206064 | |
| IntAct | P59941 | |
| STRING | 10090.ENSMUSP00000048971 | |
| PhosphoSite | P59941 | |
| MaxQB | P59941 | |
| PRIDE | P59941 | |
| Ensembl | ENSMUST00000042923 | |
| GeneID | 50721 | |
| KEGG | mmu:50721 | |
| UCSC | uc007giy.2 | |
| CTD | 51548 | |
| MGI | MGI:1354161 | |
| eggNOG | COG0846 | |
| GeneTree | ENSGT00530000063706 | |
| HOGENOM | HOG000231240 | |
| HOVERGEN | HBG060028 | |
| InParanoid | P59941 | |
| KO | K11416 | |
| OMA | PSKTHMA | |
| PhylomeDB | P59941 | |
| TreeFam | TF106184 | |
| ChiTaRS | Sirt6 | |
| NextBio | 307573 | |
| PRO | PR:P59941 | |
| Proteomes | UP000000589 | |
| Bgee | P59941 | |
| ExpressionAtlas | P59941 | |
| Genevestigator | P59941 | |
| GO | GO:0005724 GO:0005654 GO:0005634 GO:0003682 GO:0003956 GO:0070403 GO:0017136 GO:0046969 GO:0008270 GO:0061647 GO:0006471 GO:0010569 | |
| Gene3D | 3.40.50.1220 | |
| InterPro | IPR029035 IPR003000 IPR026590 | |
| PANTHER | PTHR11085 | |
| Pfam | PF02146 | |
| SUPFAM | SSF52467 | |
| PROSITE | PS50305 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008285 |
negative regulation of cell proliferation |
ECO:0000315 |
P |
Fig. 1a Shows KO of SIR6 increases cellular proliferation |
complete | |||||
| GO:0045820 |
negative regulation of glycolysis |
ECO:0000315 |
P |
Figure 2 shows SIRT6-deficient cells exhibit enhanced Aerobic Glycolysis. |
complete | |||||
| GO:0003714 |
transcription corepressor activity |
ECO:0000316 |
|
F |
Figure 4. SIRT6 Inhibits Ribosomal Gene Expression by Corepressing MYC Transcriptional Activity(A) Gene Ontology clustering of SIRT6-bound promoters. |
complete | ||||
| GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000315 |
P |
Fig. 2a shows the absence of SIRT6 reduces the proliferative rate of multiple cell types. |
complete | |||||
| GO:0006284 |
base-excision repair |
ECO:0000315 |
P |
Figure 5. indicates that SIRT6 Functions in Base Excision Repair |
complete | |||||
| GO:0042593 |
glucose homeostasis |
ECO:0000315 |
P |
Figure 7C shows a decrease of serum glucose over time in KO mice. |
complete | |||||
| GO:2000648 |
positive regulation of stem cell proliferation |
ECO:0000315 |
P |
Figure 2 |
complete | |||||
| GO:0046325 |
negative regulation of glucose import |
ECO:0000315 |
P |
Figure 1 shows Increased glucose uptake in SIRT6 deficient cells and mice |
complete | |||||
| GO:0045820 |
negative regulation of glycolysis |
ECO:0000315 |
P |
Figure 2C displays significantly higher levels of lactate in SIRT6 deficient cells when compared to WT |
complete | |||||
| GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000315 |
F |
Figure 3 shows SIRT6 directly inhibits expression of glycolytic genes functioning as an H3K9 deacetylase |
complete | |||||
| GO:0045892 |
negative regulation of transcription, DNA-dependent |
ECO:0000315 |
P |
Fig 4 |
complete | |||||
| GO:0031648 |
protein destabilization |
ECO:0000315 |
P |
Figure 6 |
complete | |||||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Figure 2 |
complete | |||||
| GO:0006476 |
protein deacetylation |
ECO:0000315 |
P |
Figure 3B: In islets with Sirt6 knocked down, acetylation of FOXO1 is increased. |
complete | |||||
|
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045820 |
negative regulation of glycolytic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0046325 |
negative regulation of glucose import |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031648 |
protein destabilization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045892 |
negative regulation of transcription, DNA-templated |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000648 |
positive regulation of stem cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042593 |
glucose homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006284 |
base-excision repair |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048146 |
positive regulation of fibroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003714 |
transcription corepressor activity |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045820 |
negative regulation of glycolytic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0017136 |
NAD-dependent histone deacetylase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006471 |
protein ADP-ribosylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|part_of |
GO:0005730 |
nucleolus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003956 |
NAD(P)+-protein-arginine ADP-ribosyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1905564 |
positive regulation of vascular endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1905555 |
positive regulation blood vessel branching |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1905549 |
positive regulation of telomeric heterochromatin assembly |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:1902732 |
positive regulation of chondrocyte proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305216 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032206 |
positive regulation of telomere maintenance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0031940 |
positive regulation of chromatin silencing at telomere |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305216 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305216 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0003247 |
post-embryonic cardiac muscle cell growth involved in heart morphogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1305216 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0033558 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006476 |
protein deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0033558 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016575 |
histone deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0017136 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061647 |
histone H3-K9 modification |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1990619 |
histone H3-K9 deacetylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046969 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0033558 |
protein deacetylase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031667 |
response to nutrient levels |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0003247 |
post-embryonic cardiac muscle cell growth involved in heart morphogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q4FZY2 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905564 |
positive regulation of vascular endothelial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905555 |
positive regulation blood vessel branching |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1905549 |
positive regulation of telomeric heterochromatin assembly |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1902732 |
positive regulation of chondrocyte proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032206 |
positive regulation of telomere maintenance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0031940 |
positive regulation of chromatin silencing at telomere |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010569 |
regulation of double-strand break repair via homologous recombination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8N6T7 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0070403 |
NAD+ binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046969 |
NAD-dependent histone deacetylase activity (H3-K9 specific) |
Reactome:R-MMU-9604841 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-MMU-9604841 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Sebastián, C et al. (2012) The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell 151 1185-99 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Mostoslavsky, R et al. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124 315-29 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Zhong, L et al. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140 280-93 PubMed GONUTS page
- ↑ 4.0 4.1 Favero, G et al. (2014) Sirtuin 6 nuclear localization at cortical brain level of young diabetic mice: an immunohistochemical study. Acta Histochem. 116 272-7 PubMed GONUTS page
- ↑ Song, MY et al. (2016) Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway. Sci Rep 6 30321 PubMed GONUTS page
- ↑ Yao, L et al. (2017) Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat. Cell Rep 20 641-654 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Liszt, G et al. (2005) Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J. Biol. Chem. 280 21313-20 PubMed GONUTS page
- ↑ Wajapeyee, N et al. (2013) Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors. Genes Dev. 27 2221-6 PubMed GONUTS page
h
n
- GO:0003956 ! NAD(P)+-protein-arginine ADP-ribosyltransferase activity
- GO:0070403 ! NAD+ binding
- GO:0045820 ! negative regulation of glycolytic process
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0045892 ! negative regulation of DNA-templated transcription
- GO:0046325 ! negative regulation of D-glucose import
- GO:0005730 ! nucleolus
- GO:0005654 ! nucleoplasm
- GO:0005634 ! nucleus
o
- GO:0016575 ! obsolete histone deacetylation
- GO:0061647 ! obsolete histone H3-K9 modification
- GO:1990619 ! obsolete histone H3-K9 deacetylation
- GO:0005724 ! obsolete nuclear telomeric heterochromatin
- GO:1905549 ! obsolete positive regulation of subtelomeric heterochromatin assembly
- GO:0031940 ! obsolete positive regulation of chromatin silencing at telomere
- GO:0006471 ! obsolete protein ADP-ribosylation
p
- GO:1902732 ! positive regulation of chondrocyte proliferation
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0048146 ! positive regulation of fibroblast proliferation
- GO:2000648 ! positive regulation of stem cell proliferation
- GO:0032206 ! positive regulation of telomere maintenance
- GO:1905555 ! positive regulation of blood vessel branching
- GO:1905564 ! positive regulation of vascular endothelial cell proliferation
- GO:0003247 ! post-embryonic cardiac muscle cell growth involved in heart morphogenesis
- GO:0006476 ! protein deacetylation
- GO:0031648 ! protein destabilization
- GO:0033558 ! protein lysine deacetylase activity
r
