MOUSE:SIR3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sirt3 (synonyms: Sir2l3)
Protein Name(s)	NAD-dependent protein deacetylase sirtuin-3 Regulatory protein SIR2 homolog 3 SIR2-like protein 3 mSIR2L3
External Links
UniProt	Q8R104
EMBL	AF299339 FJ621493 EU886466 AF302278 AF302274 AF302275 AF302276 AF302277 AF299338 AK075861 BC025878
CCDS	CCDS21989.1
RefSeq	NP_001120823.1 NP_001171275.1 NP_071878.2
UniGene	Mm.244216
ProteinModelPortal	Q8R104
SMR	Q8R104
BioGrid	211071
IntAct	Q8R104
MaxQB	Q8R104
PaxDb	Q8R104
PRIDE	Q8R104
Ensembl	ENSMUST00000026559 ENSMUST00000106048
GeneID	64384
KEGG	mmu:64384
UCSC	uc009kik.2
CTD	23410
MGI	MGI:1927665
eggNOG	COG0846
GeneTree	ENSGT00740000115546
HOVERGEN	HBG057095
InParanoid	Q8R104
KO	K11413
OMA	WETHMEC
OrthoDB	EOG7WX09C
TreeFam	TF106181
ChiTaRS	Sirt3
NextBio	320063
PRO	PR:Q8R104
Proteomes	UP000000589
Bgee	Q8R104
ExpressionAtlas	Q8R104
Genevestigator	Q8R104
GO	GO:0005737 GO:0016020 GO:0005759 GO:0005739 GO:0070403 GO:0032041 GO:0008270 GO:0009060 GO:0007568 GO:0070932 GO:0034983 GO:0006476
Gene3D	3.30.1600.10 3.40.50.1220
InterPro	IPR029035 IPR003000 IPR026591 IPR017328 IPR026590
PANTHER	PTHR11085
Pfam	PF02146
PIRSF	PIRSF037938
SUPFAM	SSF52467
PROSITE	PS50305

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005743	mitochondrial inner membrane	PMID:18054327^[1]	ECO:0000314			C		Fig. 1.	complete CACAO 7182
part_of	GO:0005743	mitochondrial inner membrane	PMID:18054327^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1903109	positive regulation of mitochondrial transcription	PMID:23283301^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0042149)	Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23283301^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23283301^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
involved_in	GO:0009060	aerobic respiration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NTG7	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000119154 PomBase:SPBC16D10.07c UniProtKB:Q8IXJ6	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927665 PANTHER:PTN002476415 UniProtKB:Q9NTG7	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927665 PANTHER:PTN002476415 UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024291 FB:FBgn0038788 MGI:MGI:2135607 PANTHER:PTN000119154 SGD:S000002200 SGD:S000005429 SGD:S000005551 SGD:S000005936 UniProtKB:Q8IXJ6 UniProtKB:Q96EB6	F		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927665 PANTHER:PTN002476415 UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1927665 PANTHER:PTN002476415 RGD:1308374 UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000757	negative regulation of peptidyl-lysine acetylation	PMID:17923681^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3769234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000757	negative regulation of peptidyl-lysine acetylation	PMID:17923681^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308374	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308374	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032024	positive regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308374	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308374	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:11056054^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009060	aerobic respiration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	PMID:23576753^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3769234	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	PMID:17923681^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:26767982^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17923681^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9NTG7	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1308374	C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0017136	P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0017136	P		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0017136	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	F		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	C		Seeded From UniProt	complete
involved_in	GO:0009060	aerobic respiration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	P		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9NTG7 ensembl:ENSP00000372191	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017328	F		Seeded From UniProt	complete
enables	GO:0017136	NAD-dependent histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017328	F		Seeded From UniProt	complete
enables	GO:0070403	NAD+ binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003000	F		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	PMID:19241369^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	PMID:19241369^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19241369^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
NOT\|enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	PMID:11056054^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11056054^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Nakamura, Y et al. (2008) Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 366 174-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yang, YH et al. (2000) Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69 355-69 PubMed GONUTS page
↑ Rardin, MJ et al. (2013) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc. Natl. Acad. Sci. U.S.A. 110 6601-6 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Jin, L et al. (2009) Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 18 514-25 PubMed GONUTS page

[PMID:18054327-1] 1.0 ^1.1 Nakamura, Y et al. (2008) Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5. Biochem. Biophys. Res. Commun. 366 174-9 PubMed GONUTS page

[PMID:23283301-2] 2.0 ^2.1 ^2.2 Peserico, A et al. (2013) A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell. Mol. Life Sci. 70 2015-29 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17923681-4] 4.0 ^4.1 ^4.2 ^4.3 Lombard, DB et al. (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell. Biol. 27 8807-14 PubMed GONUTS page

[PMID:11056054-5] 5.0 ^5.1 ^5.2 Yang, YH et al. (2000) Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene. Genomics 69 355-69 PubMed GONUTS page

[PMID:23576753-6] Rardin, MJ et al. (2013) Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc. Natl. Acad. Sci. U.S.A. 110 6601-6 PubMed GONUTS page

[PMID:18614015-7] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:26767982-8] Martin, J et al. (2016) Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am. J. Physiol. Gastrointest. Liver Physiol. 310 G497-509 PubMed GONUTS page

[PMID:19241369-9] 9.0 ^9.1 ^9.2 Jin, L et al. (2009) Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Sci. 18 514-25 PubMed GONUTS page

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MOUSE:SIR3

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