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MOUSE:SDF1
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Cxcl12 (synonyms: Sdf1) | |
Protein Name(s) | Stromal cell-derived factor 1
SDF-1 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 TPAR1 C-X-C motif chemokine 12 Pre-B cell growth-stimulating factor PBSF Thymic lymphoma cell-stimulating factor TLSF | |
External Links | ||
UniProt | P40224 | |
EMBL | L12029 L12030 S74318 D21072 D43804 D43805 AK045092 AK075596 AK157553 CT010389 CH466523 BC006640 | |
CCDS | CCDS39605.1 CCDS39606.1 | |
PIR | A53497 I81182 | |
RefSeq | NP_038683.1 NP_068350.1 | |
UniGene | Mm.303231 | |
ProteinModelPortal | P40224 | |
SMR | P40224 | |
STRING | 10090.ENSMUSP00000072800 | |
PhosphoSite | P40224 | |
MaxQB | P40224 | |
PRIDE | P40224 | |
Ensembl | ENSMUST00000112866 ENSMUST00000112871 ENSMUST00000185648 | |
GeneID | 20315 | |
KEGG | mmu:20315 | |
UCSC | uc009dks.2 | |
CTD | 6387 | |
MGI | MGI:103556 | |
eggNOG | NOG26489 | |
GeneTree | ENSGT00390000014056 | |
HOGENOM | HOG000220915 | |
HOVERGEN | HBG107437 | |
InParanoid | P40224 | |
KO | K10031 | |
OrthoDB | EOG7C5MBS | |
PhylomeDB | P40224 | |
Reactome | REACT_198574 REACT_230248 REACT_250376 | |
ChiTaRS | Cxcl12 | |
NextBio | 298091 | |
PRO | PR:P40224 | |
Proteomes | UP000000589 | |
Bgee | P40224 | |
CleanEx | MM_CXCL12 | |
ExpressionAtlas | P40224 | |
Genevestigator | P40224 | |
GO | GO:0009897 GO:0005615 GO:0008009 GO:0042379 GO:0001667 GO:0007420 GO:0060326 GO:0007281 GO:0008354 GO:0006955 GO:0050930 GO:0008045 GO:0001569 GO:0045785 GO:0030335 GO:1901741 GO:2000406 GO:0030334 GO:0042098 | |
InterPro | IPR001811 | |
Pfam | PF00048 | |
SMART | SM00199 | |
SUPFAM | SSF54117 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0033622 |
integrin activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005178 |
integrin binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0071542 |
dopaminergic neuron differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042379 |
chemokine receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070098 |
chemokine-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000428507 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0060326 |
cell chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000428507 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050930 |
induction of positive chemotaxis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103556 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0045236 |
CXCR chemokine receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000428507 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103556 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103556 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0008009 |
chemokine activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:103556 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2000669 |
negative regulation of dendritic cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2000406 |
positive regulation of T cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1990869 |
cellular response to chemokine |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1903237 |
negative regulation of leukocyte tethering or rolling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902230 |
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1901741 |
positive regulation of myoblast fusion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0098609 |
cell-cell adhesion |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090280 |
positive regulation of calcium ion import |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090026 |
positive regulation of monocyte chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070098 |
chemokine-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060326 |
cell chemotaxis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051924 |
regulation of calcium ion transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050966 |
detection of mechanical stimulus involved in sensory perception of pain |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050965 |
detection of temperature stimulus involved in sensory perception of pain |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050930 |
induction of positive chemotaxis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048842 |
positive regulation of axon extension involved in axon guidance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045785 |
positive regulation of cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045666 |
positive regulation of neuron differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0045236 |
CXCR chemokine receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042379 |
chemokine receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042098 |
T cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1934384 |
P |
acts_on_population_of:(CL:0000084) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0038146 |
chemokine (C-X-C motif) ligand 12 signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033622 |
integrin activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033603 |
positive regulation of dopamine secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0031100 |
animal organ regeneration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030335 |
positive regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030335 |
positive regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030334 |
regulation of cell migration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1306805 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030334 |
regulation of cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0022029 |
telencephalon cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008354 |
germ cell migration |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008344 |
adult locomotory behavior |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008045 |
motor neuron axon guidance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1934384 |
P |
|
Seeded From UniProt |
complete | |
enables |
GO:0008009 |
chemokine activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0008009 |
chemokine activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007420 |
brain development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
results_in_development_of:(EMAPA:19037) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007281 |
germ cell development |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005178 |
integrin binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001938 |
positive regulation of endothelial cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001764 |
neuron migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:3651 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001667 |
ameboidal-type cell migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1934384 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001569 |
branching involved in blood vessel morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1934384 |
P |
occurs_in:(EMAPA:16201)|occurs_in:(EMAPA:16255) |
Seeded From UniProt |
complete | |
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006952 |
defense response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006955 |
immune response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008009 |
chemokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001811 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070098 |
chemokine-mediated signaling pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006935 |
chemotaxis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Schwartz, CM et al. (2012) Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. J. Neurosci. Res. 90 1367-81 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
- ↑ Ge, Y et al. (2013) RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE 8 e68068 PubMed GONUTS page
- ↑ Cheng, M et al. (2010) CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ. Res. 107 1083-93 PubMed GONUTS page
- ↑ Nagasawa, T et al. (1996) Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl. Acad. Sci. U.S.A. 93 14726-9 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 Molyneaux, KA et al. (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development 130 4279-86 PubMed GONUTS page
- ↑ Ara, T et al. (2003) A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol. 170 4649-55 PubMed GONUTS page
- ↑ Dubeykovskaya, Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J. Biol. Chem. 284 3650-62 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 Bagri, A et al. (2002) The chemokine SDF1 regulates migration of dentate granule cells. Development 129 4249-60 PubMed GONUTS page
- ↑ Abe, J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173 1682-92 PubMed GONUTS page
- ↑ Lieberam, I et al. (2005) A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron 47 667-79 PubMed GONUTS page
- ↑ 13.0 13.1 Ara, T et al. (2005) The role of CXCL12 in the organ-specific process of artery formation. Blood 105 3155-61 PubMed GONUTS page
a
c
- GO:0098609 ! cell-cell adhesion
- GO:1990869 ! cellular response to chemokine
- GO:0060326 ! cell chemotaxis
- GO:0070098 ! chemokine-mediated signaling pathway
- GO:0038146 ! chemokine (C-X-C motif) ligand 12 signaling pathway
- GO:0008009 ! chemokine activity
- GO:0042379 ! chemokine receptor binding
- GO:0006935 ! chemotaxis
- Chordata
- Craniata
- GO:0045236 ! CXCR chemokine receptor binding
- GO:0005125 ! cytokine activity
- GO:0005737 ! cytoplasm
d
e
g
i
m
n
p
- GO:0005886 ! plasma membrane
- GO:0045666 ! positive regulation of neuron differentiation
- GO:0033603 ! positive regulation of dopamine secretion
- GO:0001938 ! positive regulation of endothelial cell proliferation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0030335 ! positive regulation of cell migration
- GO:0045785 ! positive regulation of cell adhesion
- GO:2000406 ! positive regulation of T cell migration
- GO:1901741 ! positive regulation of myoblast fusion
- GO:0090026 ! positive regulation of monocyte chemotaxis
- GO:0048842 ! positive regulation of axon extension involved in axon guidance
- GO:0090280 ! positive regulation of calcium ion import
r