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MOUSE:SDF1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Cxcl12 (synonyms: Sdf1)
Protein Name(s) Stromal cell-derived factor 1

SDF-1 12-O-tetradecanoylphorbol 13-acetate repressed protein 1 TPAR1 C-X-C motif chemokine 12 Pre-B cell growth-stimulating factor PBSF Thymic lymphoma cell-stimulating factor TLSF

External Links
UniProt P40224
EMBL L12029
L12030
S74318
D21072
D43804
D43805
AK045092
AK075596
AK157553
CT010389
CH466523
BC006640
CCDS CCDS39605.1
CCDS39606.1
PIR A53497
I81182
RefSeq NP_038683.1
NP_068350.1
UniGene Mm.303231
ProteinModelPortal P40224
SMR P40224
STRING 10090.ENSMUSP00000072800
PhosphoSite P40224
MaxQB P40224
PRIDE P40224
Ensembl ENSMUST00000112866
ENSMUST00000112871
ENSMUST00000185648
GeneID 20315
KEGG mmu:20315
UCSC uc009dks.2
CTD 6387
MGI MGI:103556
eggNOG NOG26489
GeneTree ENSGT00390000014056
HOGENOM HOG000220915
HOVERGEN HBG107437
InParanoid P40224
KO K10031
OrthoDB EOG7C5MBS
PhylomeDB P40224
Reactome REACT_198574
REACT_230248
REACT_250376
ChiTaRS Cxcl12
NextBio 298091
PRO PR:P40224
Proteomes UP000000589
Bgee P40224
CleanEx MM_CXCL12
ExpressionAtlas P40224
Genevestigator P40224
GO GO:0009897
GO:0005615
GO:0008009
GO:0042379
GO:0001667
GO:0007420
GO:0060326
GO:0007281
GO:0008354
GO:0006955
GO:0050930
GO:0008045
GO:0001569
GO:0045785
GO:0030335
GO:1901741
GO:2000406
GO:0030334
GO:0042098
InterPro IPR001811
Pfam PF00048
SMART SM00199
SUPFAM SSF54117

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0033622

integrin activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

involved_in

GO:0071542

dopaminergic neuron differentiation

PMID:22535492[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042379

chemokine receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000428507
UniProtKB:P48061

P

Seeded From UniProt

complete

involved_in

GO:0060326

cell chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000428507
UniProtKB:P48061

P

Seeded From UniProt

complete

involved_in

GO:0050930

induction of positive chemotaxis

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103556
PANTHER:PTN000428507

P

Seeded From UniProt

complete

enables

GO:0045236

CXCR chemokine receptor binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000428507
UniProtKB:P48061

F

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103556
PANTHER:PTN000428507
RGD:3651
UniProtKB:A0A1D5P4F0

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103556
PANTHER:PTN000428507

C

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103556
PANTHER:PTN000428507
UniProtKB:A0A1D5P4F0
UniProtKB:P48061

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000669

negative regulation of dendritic cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2000406

positive regulation of T cell migration

PMID:23620790[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990869

cellular response to chemokine

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1903237

negative regulation of leukocyte tethering or rolling

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1901741

positive regulation of myoblast fusion

PMID:23844157[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0098609

cell-cell adhesion

PMID:20847314[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090280

positive regulation of calcium ion import

PMID:8962122[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090026

positive regulation of monocyte chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060326

cell chemotaxis

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051924

regulation of calcium ion transport

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050966

detection of mechanical stimulus involved in sensory perception of pain

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050965

detection of temperature stimulus involved in sensory perception of pain

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050930

induction of positive chemotaxis

PMID:12900445[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048842

positive regulation of axon extension involved in axon guidance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045785

positive regulation of cell adhesion

PMID:23620790[3]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045666

positive regulation of neuron differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

enables

GO:0045236

CXCR chemokine receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

enables

GO:0042379

chemokine receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042098

T cell proliferation

PMID:12707343[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934384

P

acts_on_population_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0038146

chemokine (C-X-C motif) ligand 12 signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033622

integrin activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033603

positive regulation of dopamine secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031100

animal organ regeneration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

PMID:12900445[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030334

regulation of cell migration

PMID:19064997[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1306805

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030334

regulation of cell migration

PMID:12183377[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022029

telencephalon cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

part_of

GO:0009897

external side of plasma membrane

PMID:19008373[11]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18767)
  • part_of:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008354

germ cell migration

PMID:12900445[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008344

adult locomotory behavior

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008045

motor neuron axon guidance

PMID:16129397[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934384

P

  • occurs_in:(EMAPA:16531)
  • occurs_in:(CL:0000100)|occurs_in:(EMAPA:16532)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

PMID:12183377[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007420

brain development

PMID:12183377[10]

ECO:0000314

direct assay evidence used in manual assertion

P

results_in_development_of:(EMAPA:19037)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:12900445[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

C

Seeded From UniProt

complete

enables

GO:0005178

integrin binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P48061

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001938

positive regulation of endothelial cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001764

neuron migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:3651

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001667

ameboidal-type cell migration

PMID:15626744[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934384

P

  • occurs_in:(EMAPA:16201)
  • results_in_movement_of:(CL:0000071)|occurs_in(EMAPA:16255)
  • results_in_movement_of:(CL:0000071)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001569

branching involved in blood vessel morphogenesis

PMID:15626744[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1934384

P

occurs_in:(EMAPA:16201)|occurs_in:(EMAPA:16255)

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0008083

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001811
InterPro:IPR036048

C

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033899

P

Seeded From UniProt

complete

involved_in

GO:0006952

defense response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR033899

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001811
InterPro:IPR036048

P

Seeded From UniProt

complete

enables

GO:0008009

chemokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001811
InterPro:IPR033899
InterPro:IPR036048
InterPro:IPR039813

F

Seeded From UniProt

complete

involved_in

GO:0070098

chemokine-mediated signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR039813

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

involved_in

GO:0006935

chemotaxis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0145

P

Seeded From UniProt

complete

enables

GO:0008083

growth factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0339

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Schwartz, CM et al. (2012) Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. J. Neurosci. Res. 90 1367-81 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. 3.0 3.1 Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
  4. Ge, Y et al. (2013) RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation. PLoS ONE 8 e68068 PubMed GONUTS page
  5. Cheng, M et al. (2010) CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ. Res. 107 1083-93 PubMed GONUTS page
  6. Nagasawa, T et al. (1996) Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc. Natl. Acad. Sci. U.S.A. 93 14726-9 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 Molyneaux, KA et al. (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development 130 4279-86 PubMed GONUTS page
  8. Ara, T et al. (2003) A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J. Immunol. 170 4649-55 PubMed GONUTS page
  9. Dubeykovskaya, Z et al. (2009) Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J. Biol. Chem. 284 3650-62 PubMed GONUTS page
  10. 10.0 10.1 10.2 Bagri, A et al. (2002) The chemokine SDF1 regulates migration of dentate granule cells. Development 129 4249-60 PubMed GONUTS page
  11. Abe, J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am. J. Pathol. 173 1682-92 PubMed GONUTS page
  12. Lieberam, I et al. (2005) A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron 47 667-79 PubMed GONUTS page
  13. 13.0 13.1 Ara, T et al. (2005) The role of CXCL12 in the organ-specific process of artery formation. Blood 105 3155-61 PubMed GONUTS page