MOUSE:SALL4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Sall4
Protein Name(s)	Sal-like protein 4 Zinc finger protein SALL4
External Links
UniProt	Q8BX22
EMBL	AY463371 AY463372 AY463373 AK049188 AL929248 CH466551 AJ488904
CCDS	CCDS17115.1 CCDS17116.1 CCDS17117.1
RefSeq	NP_780512.2 NP_958797.2 NP_958798.2
UniGene	Mm.434054 Mm.491245
ProteinModelPortal	Q8BX22
BioGrid	221236
DIP	DIP-29926N
IntAct	Q8BX22
MINT	Q8BX22
STRING	10090.ENSMUSP00000029061
iPTMnet	Q8BX22
PhosphoSitePlus	Q8BX22
PaxDb	Q8BX22
PeptideAtlas	Q8BX22
PRIDE	Q8BX22
DNASU	99377
Ensembl	ENSMUST00000029061 ENSMUST00000075044 ENSMUST00000103074
GeneID	99377
KEGG	mmu:99377
UCSC	uc008obf.1 uc008obg.1 uc008obh.1
CTD	57167
MGI	MGI:2139360
eggNOG	KOG1074 ENOG410ZE3Z
GeneTree	ENSGT00550000074555
HOGENOM	HOG000231986
HOVERGEN	HBG058921
InParanoid	Q8BX22
KO	K19871
OMA	GVHRTNT
OrthoDB	EOG091G00R1
TreeFam	TF317003
Reactome	R-MMU-8943724
PRO	PR:Q8BX22
Proteomes	UP000000589
Bgee	ENSMUSG00000027547
CleanEx	MM_SALL4
ExpressionAtlas	Q8BX22
Genevisible	Q8BX22
GO	GO:0005737 GO:0000792 GO:0043231 GO:0005654 GO:0005634 GO:0032991 GO:0005667 GO:0003700 GO:0046872 GO:0043565 GO:0008134 GO:0044212 GO:0030326 GO:0007507 GO:0001701 GO:0001833 GO:0000122 GO:0001843 GO:0021915 GO:0022008 GO:0045944 GO:0007165 GO:0019827 GO:0009888 GO:0006351 GO:0003281
InterPro	IPR036236 IPR013087
Pfam	PF00096
SMART	SM00355
SUPFAM	SSF57667
PROSITE	PS00028 PS50157

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1905437	positive regulation of histone H3-K4 trimethylation	PMID:26691508^[1]	ECO:0000314			P		Fig. 2 (top panel) shows that in mice, levels of H3K4 trimethylation associated with the Sall4 promoter increase during reprogramming.	complete CACAO 13395
enables	GO:0008134	transcription factor binding	PMID:26523946^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9Q3T6	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000287 FB:FBgn0261648 MGI:MGI:1889585 MGI:MGI:2139360 PANTHER:PTN000579342 UniProtKB:Q9NSC2	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261648 PANTHER:PTN000579342	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16380715^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16380715^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UJQ4	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19796622^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:16380715^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P	has_participant:(EMAPA:17429)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030326	embryonic limb morphogenesis	PMID:16380715^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587949	P	has_participant:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021915	neural tube development	PMID:18818376^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1354373 MGI:MGI:1889585	P	results_in_development_of:(EMAPA:16073)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019827	stem cell population maintenance	PMID:20720539^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009888	tissue development	PMID:17060609^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3692447	P	results_in_development_of:(EMAPA:16052)\|results_in_development_of:(EMAPA:16051)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:16380715^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3587949	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:16380715^[4]	ECO:0000305	curator inference used in manual assertion	GO:0005515 GO:0045944	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9UJQ4	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003281	ventricular septum development	PMID:16790473^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1889585	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003281	ventricular septum development	PMID:16790473^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3699175	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:16790473^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1889585	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:16790473^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3699175	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001833	inner cell mass cell proliferation	PMID:16790473^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3699175	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17060609^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3692447	P	has_participant:(EMAPA:16050)\|has_participant:(EMAPA:16052)\|has_participant:(EMAPA:16051)	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:17295837^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16380715^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:102541	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UJQ4 ensembl:ENSP00000217086	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9UJQ4 ensembl:ENSP00000217086	C		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013087	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page
↑ Iseki, H et al. (2016) Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells 34 322-33 PubMed GONUTS page
↑ ^3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Koshiba-Takeuchi, K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat. Genet. 38 175-83 PubMed GONUTS page
↑ ^5.0 ^5.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ Böhm, J et al. (2008) Sall1, sall2, and sall4 are required for neural tube closure in mice. Am. J. Pathol. 173 1455-63 PubMed GONUTS page
↑ Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page
↑ ^8.0 ^8.1 Elling, U et al. (2006) Murine inner cell mass-derived lineages depend on Sall4 function. Proc. Natl. Acad. Sci. U.S.A. 103 16319-24 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Sakaki-Yumoto, M et al. (2006) The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development 133 3005-13 PubMed GONUTS page
↑ Yamashita, K et al. (2007) Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells 12 171-82 PubMed GONUTS page

[PMID:26691508-1] Yang, Z et al. (2015) Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS ONE 10 e0145336 PubMed GONUTS page

[PMID:26523946-2] Iseki, H et al. (2016) Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells 34 322-33 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16380715-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Koshiba-Takeuchi, K et al. (2006) Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart. Nat. Genet. 38 175-83 PubMed GONUTS page

[PMID:19796622-5] 5.0 ^5.1 Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:18818376-6] Böhm, J et al. (2008) Sall1, sall2, and sall4 are required for neural tube closure in mice. Am. J. Pathol. 173 1455-63 PubMed GONUTS page

[PMID:20720539-7] Kagey, MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature 467 430-5 PubMed GONUTS page

[PMID:17060609-8] 8.0 ^8.1 Elling, U et al. (2006) Murine inner cell mass-derived lineages depend on Sall4 function. Proc. Natl. Acad. Sci. U.S.A. 103 16319-24 PubMed GONUTS page

[PMID:16790473-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Sakaki-Yumoto, M et al. (2006) The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development 133 3005-13 PubMed GONUTS page

[PMID:17295837-10] Yamashita, K et al. (2007) Mouse homolog of SALL1, a causative gene for Townes-Brocks syndrome, binds to A/T-rich sequences in pericentric heterochromatin via its C-terminal zinc finger domains. Genes Cells 12 171-82 PubMed GONUTS page

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MOUSE:SALL4

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