MOUSE:RYR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ryr1
Protein Name(s)	Ryanodine receptor 1 RYR-1 RyR1 Skeletal muscle calcium release channel Skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor Type 1 ryanodine receptor
External Links
UniProt	E9PZQ0
EMBL	AY268935 AC164564 AC165142 D21798 D21796 D21797 AJ308737 BC051248 BC055487 X83932 U23754 D38216
CCDS	CCDS39866.1
PIR	I48741 I58087 I78376 I78377 S56105
RefSeq	NP_033135.2
UniGene	Mm.439745
ProteinModelPortal	E9PZQ0
SMR	E9PZQ0
DIP	DIP-29705N
IntAct	E9PZQ0
STRING	10090.ENSMUSP00000032813
BindingDB	E9PZQ0
ChEMBL	CHEMBL2133
GuidetoPHARMACOLOGY	747
PhosphoSite	E9PZQ0
MaxQB	E9PZQ0
PRIDE	E9PZQ0
Ensembl	ENSMUST00000179893
GeneID	20190
KEGG	mmu:20190
UCSC	uc009gao.1
CTD	6261
MGI	MGI:99659
GeneTree	ENSGT00760000119152
HOGENOM	HOG000231428
HOVERGEN	HBG102939
InParanoid	E9PZQ0
KO	K04961
OMA	QCSATVL
OrthoDB	EOG71K622
TreeFam	TF315244
Reactome	REACT_196640
NextBio	297735
PRO	PR:E9PZQ0
Proteomes	UP000000589
Bgee	E9PZQ0
ExpressionAtlas	E9PZQ0
Genevestigator	Q62235
GO	GO:0005938 GO:0070062 GO:0031674 GO:0016021 GO:0030314 GO:0016020 GO:0043234 GO:0016529 GO:0033017 GO:0005790 GO:0030315 GO:0005262 GO:0005509 GO:0019899 GO:0002020 GO:0005219 GO:0005245 GO:0006816 GO:0071313 GO:0006936 GO:0043931 GO:0003151 GO:0006937 GO:0051209 GO:0014808 GO:0001666 GO:0048741 GO:0043588
Gene3D	1.10.238.10 1.25.10.30
InterPro	IPR001870 IPR013320 IPR011992 IPR014821 IPR005821 IPR016093 IPR013662 IPR000699 IPR013333 IPR003032 IPR015925 IPR009460 IPR003877
PANTHER	PTHR13715
Pfam	PF08709 PF00520 PF02815 PF08454 PF06459 PF01365 PF02026 PF00622
PRINTS	PR00795
SMART	SM00472 SM00449
SUPFAM	SSF100909 SSF49899 SSF82109
PROSITE	PS50188 PS50919

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:23131566^[1]	ECO:0000315			F		Figure 1C, Figure 3C	complete CACAO 5724
	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	PMID:23131566^[1]	ECO:0000315			P		Figure 4A.	complete CACAO 5726
	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	PMID:23131566^[1]	ECO:0000315			P		Figure 4A.	complete CACAO 5727
	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:23131566^[1]	ECO:0000315			F		Figure 4A.	complete CACAO 5728
part_of	GO:0014802	terminal cisterna	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1LMY4	C		Seeded From UniProt	complete
part_of	GO:1990425	ryanodine receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	C		Seeded From UniProt	complete
part_of	GO:0031301	integral component of organelle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	C		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	F		Seeded From UniProt	complete
involved_in	GO:0071277	cellular response to calcium ion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	F		Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P		Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11716	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:19198614^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P26883	F	occurs_in:(UBERON:0001134)	Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	PMID:7621815^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048741	skeletal muscle fiber development	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043931	ossification involved in bone maturation	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:18676612^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:18003898^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006936	muscle contraction	PMID:7515481^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:18003898^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:7621815^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003151	outflow tract morphogenesis	PMID:18003898^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:18676612^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P16259	F		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010051 MGI:MGI:96623 MGI:MGI:99659 PANTHER:PTN001416417 RGD:1586637 RGD:2933 RGD:69649 UniProtKB:P21817 UniProtKB:Q92736	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346461 RGD:1586637 RGD:620314	C		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 UniProtKB:Q92736	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99684 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0030659	cytoplasmic vesicle membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000346459 dictyBase:DDB_G0292564	C		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99685 PANTHER:PTN000346461 RGD:620314 UniProtKB:Q92736	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2933 RGD:620314 UniProtKB:P21817 UniProtKB:Q14571 UniProtKB:Q14573	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001416417 RGD:2934 RGD:69649	F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99659 MGI:MGI:99685 PANTHER:PTN000346461 RGD:1586637 RGD:620314 RGD:68952 UniProtKB:P21817 UniProtKB:Q92736 ZFIN:ZDB-GENE-070705-417	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071318	cellular response to ATP	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071313	cellular response to caffeine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070296	sarcoplasmic reticulum calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051480	regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	PMID:12704193^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2152826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	F		Seeded From UniProt	complete
part_of	GO:0042383	sarcolemma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	PMID:14592808^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	C		Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031000	response to caffeine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:8943043^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:23695157^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32716)	Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:22355118^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030315	T-tubule	PMID:15536090^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030314	junctional membrane complex	PMID:10444070^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19318) part_of:(CL:0000188)\|part_of:(EMAPA:19144) part_of:(CL:0000188)\|part_of:(EMAPA:17701) part_of:(CL:0000188)	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:8943043^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:7832748^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35578)	Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:15536090^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:12954602^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	PMID:11784029^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7832748^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:12704193^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
part_of	GO:0014802	terminal cisterna	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006936	muscle contraction	PMID:12704193^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2152826	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006936	muscle contraction	PMID:12954602^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12954602^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	C		Seeded From UniProt	complete
part_of	GO:0005790	smooth endoplasmic reticulum	PMID:23454728^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	C		Seeded From UniProt	complete
enables	GO:0005245	voltage-gated calcium channel activity	PMID:12954602^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1586637	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P21817	P		Seeded From UniProt	complete
involved_in	GO:0071313	cellular response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	P		Seeded From UniProt	complete
enables	GO:0048763	calcium-induced calcium release activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	F		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	C		Seeded From UniProt	complete
part_of	GO:0031674	I band	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	C		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P21817 ensembl:ENSP00000352608	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	F		Seeded From UniProt	complete
enables	GO:0005219	ryanodine-sensitive calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460 InterPro:IPR013333	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002048	F		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013333 InterPro:IPR015925	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	P		Seeded From UniProt	complete
enables	GO:0015278	calcium-release channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033215	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699 InterPro:IPR005821 InterPro:IPR016093 InterPro:IPR036300	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009460	C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005821	P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000699	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006937	regulation of muscle contraction	PMID:11784029^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016529	sarcoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0703 UniProtKB-SubCell:SL-0239	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0107	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0109	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0033017	sarcoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0241	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Suzuki, M et al. (2012) Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin. Biochem. Biophys. Res. Commun. 429 18-23 PubMed GONUTS page
↑ Bellinger, AM et al. (2009) Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat. Med. 15 325-30 PubMed GONUTS page
↑ ^3.0 ^3.1 Takeshima, H et al. (1995) Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor. EMBO J. 14 2999-3006 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Zvaritch, E et al. (2007) An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc. Natl. Acad. Sci. U.S.A. 104 18537-42 PubMed GONUTS page
↑ ^5.0 ^5.1 Kramerova, I et al. (2008) Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum. Mol. Genet. 17 3271-80 PubMed GONUTS page
↑ Takeshima, H et al. (1994) Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature 369 556-9 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Avila, G et al. (2003) FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J. Biol. Chem. 278 22600-8 PubMed GONUTS page
↑ Wang, YX et al. (2004) FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am. J. Physiol., Cell Physiol. 286 C538-46 PubMed GONUTS page
↑ ^10.0 ^10.1 Gregg, RG et al. (1996) Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc. Natl. Acad. Sci. U.S.A. 93 13961-6 PubMed GONUTS page
↑ Al-Qusairi, L et al. (2013) Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways. FASEB J. 27 3384-94 PubMed GONUTS page
↑ Swift, F et al. (2012) Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc. Natl. Acad. Sci. U.S.A. 109 3997-4001 PubMed GONUTS page
↑ ^13.0 ^13.1 Obermair, GJ et al. (2005) The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling. J. Biol. Chem. 280 2229-37 PubMed GONUTS page
↑ Flucher, BE et al. (1999) Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J. Cell Biol. 146 621-30 PubMed GONUTS page
↑ ^15.0 ^15.1 Futatsugi, A et al. (1995) Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA. Biochem. J. 305 ( Pt 2) 373-8 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Shtifman, A et al. (2004) Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle. Am. J. Physiol., Cell Physiol. 286 C73-8 PubMed GONUTS page
↑ ^17.0 ^17.1 Takekura, H et al. (2001) Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle. Dev. Biol. 239 204-14 PubMed GONUTS page
↑ Kaya, L et al. (2013) Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons. Biochim. Biophys. Acta 1833 1421-33 PubMed GONUTS page

[PMID:23131566-1] 1.0 ^1.1 ^1.2 ^1.3 Suzuki, M et al. (2012) Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant huntingtin. Biochem. Biophys. Res. Commun. 429 18-23 PubMed GONUTS page

[PMID:19198614-2] Bellinger, AM et al. (2009) Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle. Nat. Med. 15 325-30 PubMed GONUTS page

[PMID:7621815-3] 3.0 ^3.1 Takeshima, H et al. (1995) Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor. EMBO J. 14 2999-3006 PubMed GONUTS page

[PMID:18003898-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Zvaritch, E et al. (2007) An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc. Natl. Acad. Sci. U.S.A. 104 18537-42 PubMed GONUTS page

[PMID:18676612-5] 5.0 ^5.1 Kramerova, I et al. (2008) Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum. Mol. Genet. 17 3271-80 PubMed GONUTS page

[PMID:7515481-6] Takeshima, H et al. (1994) Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene. Nature 369 556-9 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12704193-8] 8.0 ^8.1 ^8.2 Avila, G et al. (2003) FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J. Biol. Chem. 278 22600-8 PubMed GONUTS page

[PMID:14592808-9] Wang, YX et al. (2004) FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells. Am. J. Physiol., Cell Physiol. 286 C538-46 PubMed GONUTS page

[PMID:8943043-10] 10.0 ^10.1 Gregg, RG et al. (1996) Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc. Natl. Acad. Sci. U.S.A. 93 13961-6 PubMed GONUTS page

[PMID:23695157-11] Al-Qusairi, L et al. (2013) Lack of myotubularin (MTM1) leads to muscle hypotrophy through unbalanced regulation of the autophagy and ubiquitin-proteasome pathways. FASEB J. 27 3384-94 PubMed GONUTS page

[PMID:22355118-12] Swift, F et al. (2012) Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout. Proc. Natl. Acad. Sci. U.S.A. 109 3997-4001 PubMed GONUTS page

[PMID:15536090-13] 13.0 ^13.1 Obermair, GJ et al. (2005) The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling. J. Biol. Chem. 280 2229-37 PubMed GONUTS page

[PMID:10444070-14] Flucher, BE et al. (1999) Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers. J. Cell Biol. 146 621-30 PubMed GONUTS page

[PMID:7832748-15] 15.0 ^15.1 Futatsugi, A et al. (1995) Tissue-specific and developmentally regulated alternative splicing in mouse skeletal muscle ryanodine receptor mRNA. Biochem. J. 305 ( Pt 2) 373-8 PubMed GONUTS page

[PMID:12954602-16] 16.0 ^16.1 ^16.2 ^16.3 Shtifman, A et al. (2004) Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle. Am. J. Physiol., Cell Physiol. 286 C73-8 PubMed GONUTS page

[PMID:11784029-17] 17.0 ^17.1 Takekura, H et al. (2001) Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle. Dev. Biol. 239 204-14 PubMed GONUTS page

[PMID:23454728-18] Kaya, L et al. (2013) Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons. Biochim. Biophys. Acta 1833 1421-33 PubMed GONUTS page

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MOUSE:RYR1

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