MOUSE:RHOA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rhoa (synonyms: Arha, Arha2)
Protein Name(s)	Transforming protein RhoA
External Links
UniProt	Q9QUI0
EMBL	AF014371 AF178958 AF178959 AF178960 AF178961 AK077606 AK083624 BC068115
CCDS	CCDS23521.1
RefSeq	NP_058082.2 XP_006511696.1
UniGene	Mm.318359 Mm.757
PDB	4F38
PDBsum	4F38
ProteinModelPortal	Q9QUI0
SMR	Q9QUI0
BioGrid	198192
DIP	DIP-29984N
IntAct	Q9QUI0
MINT	MINT-118662
PhosphoSite	Q9QUI0
MaxQB	Q9QUI0
PaxDb	Q9QUI0
PRIDE	Q9QUI0
Ensembl	ENSMUST00000007959
GeneID	11848
KEGG	mmu:11848
UCSC	uc009rpe.2
CTD	387
MGI	MGI:1096342
eggNOG	COG1100
GeneTree	ENSGT00760000119020
HOGENOM	HOG000233974
HOVERGEN	HBG009351
InParanoid	Q9QUI0
KO	K04513
OMA	RNDPHTI
OrthoDB	EOG73FQPD
PhylomeDB	Q9QUI0
TreeFam	TF300837
Reactome	REACT_196549 REACT_203657 REACT_204733 REACT_205300 REACT_210090 REACT_214043 REACT_214242 REACT_220092 REACT_223974 REACT_239484 REACT_243939 REACT_246650 REACT_257088 REACT_257656
ChiTaRS	Rhoa
NextBio	279815
PRO	PR:Q9QUI0
Proteomes	UP000000589
Bgee	Q9QUI0
CleanEx	MM_RHOA
ExpressionAtlas	Q9QUI0
Genevestigator	Q9QUI0
GO	GO:0043296 GO:0030424 GO:0005938 GO:0032154 GO:0005856 GO:0005829 GO:0070062 GO:0005925 GO:0030027 GO:0030496 GO:0005739 GO:0005634 GO:0005886 GO:0032587 GO:0019003 GO:0005525 GO:0003924 GO:0017022 GO:0030036 GO:0030521 GO:0043297 GO:0038027 GO:0007155 GO:0030154 GO:0000902 GO:0007160 GO:0021795 GO:0036089 GO:0007010 GO:0021861 GO:0007229 GO:0008152 GO:0050919 GO:0043124 GO:0033144 GO:0043524 GO:0045665 GO:0048812 GO:0043931 GO:0030838 GO:0045785 GO:0030307 GO:0030335 GO:0043280 GO:0032467 GO:0043123 GO:0043525 GO:0045666 GO:0071803 GO:0045987 GO:0051496 GO:0045727 GO:0045907 GO:0051924 GO:0030334 GO:0050773 GO:2000177 GO:0010975 GO:0033688 GO:0006357 GO:0043200 GO:0042493 GO:0045471 GO:0051384 GO:0009749 GO:0001666 GO:0009612 GO:0007266 GO:1902766 GO:0007519 GO:0090307 GO:0043149 GO:0031098 GO:0061383 GO:0044319
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
PRINTS	PR00449
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0046638	positive regulation of alpha-beta T cell differentiation	PMID:25398325^[1]	ECO:0000315			P		Fig 2B: the DN4:DN3 ratio decreased in mice without RhoA, indicating that transition from DN3 to DN4 (beta selection) is blocked RhoA absence Fig 3B: apoptosis of DN4 cells increased to a larger extent than apoptosis of DN3 cells in mice without RhoA	complete CACAO 10938
	GO:0043366	beta selection	PMID:25398325^[1]	ECO:0000315			P		Fig 2B: the DN4:DN3 ratio decreased in mice without RhoA, indicating that transition from DN3 to DN4 (beta selection) is blocked RhoA absence Fig 3B: apoptosis of DN4 cells increased to a larger extent than apoptosis of DN3 cells in mice without RhoA	complete CACAO 10939
	GO:0032956	regulation of actin cytoskeleton organization	PMID:25398325^[1]	ECO:0000315			P		Fig 5D: little/no F-actin was found in multinucleus cells without RhoA	complete CACAO 10942
	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:25398325^[1]	ECO:0000315			P		Fig 5E: beta-tubulin was not found in multinucleus cells without RhoA Fig 5F: fluoresence of beta-tubulin decreased in single nucleus cells without RhoA	complete CACAO 10943
	GO:1902234	positive regulation of positive thymic T cell selection	PMID:25398325^[1]	ECO:0000315			P		Fig 4B: more TCRint CD69+ (double positive cells at the beginning of positive selection) than TCRhi CD69+ and TCRhi CD69- (immature and mature single positive cells after positive selection) in cells without RhoA - the ratio of these cells in the wildtype is closer to 1:1:1 Fig 4C: p14TCR mice had fewer CD8+ SP cells than wildtype - p14TCR cells have a mutation in TCRVa2Vb8 that causes them to undergo positive selection at a higher rate than wildtype cells, so they normally form a lot of CD8+ SP cells (result of positive selection and the subsequent transition phase)	complete CACAO 10944
	GO:0002363	alpha-beta T cell lineage commitment	PMID:25398325^[1]	ECO:0000315			P		Fig 4D: fewer CD4+ CD8int cells are formed from cells without RhoA - RhoA affects lineage commitment in cells lineage commitment involves the transformation of double positive (DP) cells to CD4+ CD8int and the subsequent transformation of CD4+ CD8int to either CD4+ SP or CD8+ SP	complete CACAO 10945
	GO:0090324	negative regulation of oxidative phosphorylation	PMID:25398325^[1]	ECO:0000315			P		Fig 6A: OCR (associated with oxidative phosphorylation) levels increased in cells without RhoA Fig 6B: amount of mRNA for various genes associated with oxidative phosphorylation increased in cells without RhoA	complete CACAO 10947
	GO:0045820	negative regulation of glycolytic process	PMID:25398325^[1]	ECO:0000315			P		Fig 5C: level of ECAR (associated with glycolysis) increased in cells without RHoA Fig 5D: more mRNA for genes associated with glycolysis was produced in cells without RhoA	complete CACAO 10948
	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	PMID:25398325^[1]	ECO:0000315			P		Fig 7A: reactive oxygen species (ROS) levels increased in cells without RhoA	complete CACAO 10949
involved_in	GO:0010812	negative regulation of cell-substrate adhesion	PMID:18981818^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000129) has_regulation_target:(UniProtKB:P11835) has_input:(CHEBI:64647)	Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:1990869	cellular response to chemokine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
involved_in	GO:1903673	mitotic cleavage furrow formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0042476	odontogenesis	PMID:25911094^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	part_of:(CL:0000059)	Seeded From UniProt	complete
involved_in	GO:1903427	negative regulation of reactive oxygen species biosynthetic process	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090324	negative regulation of oxidative phosphorylation	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002363	alpha-beta T cell lineage commitment	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070507	regulation of microtubule cytoskeleton organization	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043366	beta selection	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	PMID:25398325^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1CG58	P		Seeded From UniProt	complete
involved_in	GO:1902766	skeletal muscle satellite cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P		Seeded From UniProt	complete
involved_in	GO:0044319	wound healing, spreading of cells	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:G1MTS2	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	F		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0061383	trabecula morphogenesis	PMID:22019888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043931	ossification involved in bone maturation	PMID:22019888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033688	regulation of osteoblast proliferation	PMID:22019888^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	PMID:20974804^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:21543326^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
involved_in	GO:0051017	actin filament bundle assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:O00212	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 UniProtKB:Q92730	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:P61586	C		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096342 PANTHER:PTN000632769 UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 UniProtKB:P61586 ZFIN:ZDB-GENE-040322-2	P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:P61586	C		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632769 UniProtKB:I3LVS7 UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0032153	cell division site	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC20H4.11c PomBase:SPAC23C4.08	C		Seeded From UniProt	complete
involved_in	GO:0030950	establishment or maintenance of actin cytoskeleton polarity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16.01 PomBase:SPAC1F7.04 SGD:S000001380 UniProtKB:I3LVS7	P		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:P61586 UniProtKB:P62745	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108446 PANTHER:PTN000632672 WB:WBGene00004357	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001178055 UniProtKB:P61586	P		Seeded From UniProt	complete
involved_in	GO:0008360	regulation of cell shape	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000632672 PomBase:SPAC16A10.04	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 UniProtKB:Q92730 UniProtKB:Q9HBH0	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 PomBase:SPAC16A10.04 UniProtKB:I3LVS7 UniProtKB:P61586 WB:WBGene00004357	C		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000192659 MGI:MGI:106028 MGI:MGI:107949 MGI:MGI:1096342 PANTHER:PTN000632672 PomBase:SPAC23C4.08 SGD:S000001763 UniProtKB:A0A1D8PH96 UniProtKB:P62745 UniProtKB:Q92730	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0014020 PANTHER:PTN000632672 RGD:619921	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000406	positive regulation of T cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000177	regulation of neural precursor cell proliferation	PMID:22405202^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4950374	P	regulates_o_occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990869	cellular response to chemokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904695	positive regulation of vascular smooth muscle contraction	PMID:24335996^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903673	mitotic cleavage furrow formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097498	endothelial tube lumen extension	PMID:20208559^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090307	mitotic spindle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	PMID:20208559^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071803	positive regulation of podosome assembly	PMID:21525037^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858952 MGI:MGI:98397	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060193	positive regulation of lipase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051924	regulation of calcium ion transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	PMID:15467718^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
enables	GO:0051022	Rho GDP-dissociation inhibitor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050919	negative chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050773	regulation of dendrite development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046039	GTP metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045792	negative regulation of cell size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	PMID:17143286^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O35791 UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043542	endothelial cell migration	PMID:20208559^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:15071095^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:17577) regulates_o_occurs_in:(CL:0000100)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043297	apical junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043149	stress fiber assembly	PMID:14614988^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043149	stress fiber assembly	PMID:10699171^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043149	stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038027	apolipoprotein A-I-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036089	cleavage furrow formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035385	Roundabout signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034329	cell junction assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	PMID:16254014^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:9214622^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032467	positive regulation of cytokinesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
colocalizes_with	GO:0032154	cleavage furrow	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031098	stress-activated protein kinase signaling cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030521	androgen receptor signaling pathway	PMID:16254014^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030307	positive regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:11877460^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	PMID:1643657^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:18824598^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021861	forebrain radial glial cell differentiation	PMID:22405202^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4950374	P	occurs_in:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021795	cerebral cortex cell migration	PMID:22405202^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4950374	P	occurs_in:(EMAPA:32842) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	F		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010977	negative regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010975	regulation of neuron projection development	PMID:21976490^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:11877460^[19]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_development_of:(EMAPA:32717)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007160	cell-matrix adhesion	PMID:1643657^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:14657280^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007010	cytoskeleton organization	PMID:22405202^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4950374	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000681)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:18332105^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15093731^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11877460^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[26]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15093731^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:15798203^[27]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:15249579^[28]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10699171^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P61586	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619921	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003100	regulation of systemic arterial blood pressure by endothelin	PMID:24335996^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001998	angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure	PMID:24335996^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:15860730^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107187	P		Seeded From UniProt	complete
involved_in	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:1903673	mitotic cleavage furrow formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
involved_in	GO:0097498	endothelial tube lumen extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0090307	mitotic spindle assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0060193	positive regulation of lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0050919	negative chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0045792	negative regulation of cell size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0045198	establishment of epithelial cell apical/basal polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0043297	apical junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0043296	apical junction complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
involved_in	GO:0043149	stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0038027	apolipoprotein A-I-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0036089	cleavage furrow formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0035385	Roundabout signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0034329	cell junction assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0032956	regulation of actin cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0032467	positive regulation of cytokinesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
enables	GO:0017022	myosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	F		Seeded From UniProt	complete
involved_in	GO:1905244	regulation of modification of synaptic structure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
enables	GO:0051022	Rho GDP-dissociation inhibitor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
involved_in	GO:0050773	regulation of dendrite development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0046039	GTP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045987	positive regulation of smooth muscle contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045907	positive regulation of vasoconstriction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045665	negative regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
enables	GO:0019003	GDP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
involved_in	GO:0010977	negative regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0008064	regulation of actin polymerization or depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61589 ensembl:ENSRNOP00000066672	P		Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
involved_in	GO:1990869	cellular response to chemokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P61586 ensembl:ENSP00000400175	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-MMU-8981447 Reactome:R-MMU-5667058 Reactome:R-MMU-5666183 Reactome:R-MMU-5625893	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007266	Rho protein signal transduction	PMID:7888179^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	PMID:7888179^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:7888179^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:7888179^[30]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0051301	cell division	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0132	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206 UniProtKB-SubCell:SL-0090	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0138	C		Seeded From UniProt	complete
part_of	GO:0032154	cleavage furrow	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0467	C		Seeded From UniProt	complete
part_of	GO:0030496	midbody	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0469	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Zhang, S et al. (2014) Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. J. Immunol. 193 5973-82 PubMed GONUTS page
↑ Jeon, YJ et al. (2008) Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA. Neuroreport 19 1661-5 PubMed GONUTS page
↑ Lee, HK et al. (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. J. Biol. Chem. 290 14740-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Negishi-Koga, T et al. (2011) Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat. Med. 17 1473-80 PubMed GONUTS page
↑ Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page
↑ Wu, C et al. (2011) Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J. Biol. Chem. 286 23511-20 PubMed GONUTS page
↑ ^7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Cappello, S et al. (2012) A radial glia-specific role of RhoA in double cortex formation. Neuron 73 911-24 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bai, X et al. (2013) The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nat Commun 4 2910 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Lin, Y et al. (2010) DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 29 3010-6 PubMed GONUTS page
↑ Kuroiwa, M et al. (2011) The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J. Cell. Sci. 124 1726-38 PubMed GONUTS page
↑ Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page
↑ Schmahl, J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39 52-60 PubMed GONUTS page
↑ Kobayashi, K et al. (2004) Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J. Neurosci. 24 3480-8 PubMed GONUTS page
↑ Karnik, SK et al. (2003) Elastin induces myofibrillogenesis via a specific domain, VGVAPG. Matrix Biol. 22 409-25 PubMed GONUTS page
↑ ^16.0 ^16.1 Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page
↑ ^17.0 ^17.1 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page
↑ Watanabe, N et al. (1997) p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16 3044-56 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Beqaj, S et al. (2002) High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis. J. Cell Biol. 156 893-903 PubMed GONUTS page
↑ ^20.0 ^20.1 Ridley, AJ & Hall, A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70 389-99 PubMed GONUTS page
↑ Ernkvist, M et al. (2009) The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood 113 244-53 PubMed GONUTS page
↑ Fisher, D et al. (2011) Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J. Neurosci. 31 14051-66 PubMed GONUTS page
↑ Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page
↑ Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page
↑ ^25.0 ^25.1 Yonemura, S et al. (2004) Rho localization in cells and tissues. Exp. Cell Res. 295 300-14 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Kuwahara, K et al. (2005) Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 25 3173-81 PubMed GONUTS page
↑ Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page
↑ Pixley, FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J. Cell. Sci. 118 1873-83 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 Hall, A (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10 31-54 PubMed GONUTS page

[PMID:25398325-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Zhang, S et al. (2014) Gene targeting RhoA reveals its essential role in coordinating mitochondrial function and thymocyte development. J. Immunol. 193 5973-82 PubMed GONUTS page

[PMID:18981818-2] Jeon, YJ et al. (2008) Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA. Neuroreport 19 1661-5 PubMed GONUTS page

[PMID:25911094-3] Lee, HK et al. (2015) Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. J. Biol. Chem. 290 14740-53 PubMed GONUTS page

[PMID:22019888-4] 4.0 ^4.1 ^4.2 Negishi-Koga, T et al. (2011) Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat. Med. 17 1473-80 PubMed GONUTS page

[PMID:20974804-5] Wallace, SW et al. (2011) The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol. Cell. Biol. 31 81-91 PubMed GONUTS page

[PMID:21543326-6] Wu, C et al. (2011) Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J. Biol. Chem. 286 23511-20 PubMed GONUTS page

[PMID:21873635-7] 7.00 ^7.01 ^7.02 ^7.03 ^7.04 ^7.05 ^7.06 ^7.07 ^7.08 ^7.09 ^7.10 ^7.11 ^7.12 ^7.13 ^7.14 ^7.15 ^7.16 ^7.17 ^7.18 ^7.19 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22405202-8] 8.0 ^8.1 ^8.2 ^8.3 Cappello, S et al. (2012) A radial glia-specific role of RhoA in double cortex formation. Neuron 73 911-24 PubMed GONUTS page

[PMID:24335996-9] 9.0 ^9.1 ^9.2 Bai, X et al. (2013) The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nat Commun 4 2910 PubMed GONUTS page

[PMID:20208559-10] 10.0 ^10.1 ^10.2 Lin, Y et al. (2010) DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 29 3010-6 PubMed GONUTS page

[PMID:21525037-11] Kuroiwa, M et al. (2011) The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J. Cell. Sci. 124 1726-38 PubMed GONUTS page

[PMID:15467718-12] Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

[PMID:17143286-13] Schmahl, J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat. Genet. 39 52-60 PubMed GONUTS page

[PMID:15071095-14] Kobayashi, K et al. (2004) Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J. Neurosci. 24 3480-8 PubMed GONUTS page

[PMID:14614988-15] Karnik, SK et al. (2003) Elastin induces myofibrillogenesis via a specific domain, VGVAPG. Matrix Biol. 22 409-25 PubMed GONUTS page

[PMID:10699171-16] 16.0 ^16.1 Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page

[PMID:16254014-17] 17.0 ^17.1 Khan, OY et al. (2006) Multifunction steroid receptor coactivator, E6-associated protein, is involved in development of the prostate gland. Mol. Endocrinol. 20 544-59 PubMed GONUTS page

[PMID:9214622-18] Watanabe, N et al. (1997) p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16 3044-56 PubMed GONUTS page

[PMID:11877460-19] 19.0 ^19.1 ^19.2 Beqaj, S et al. (2002) High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis. J. Cell Biol. 156 893-903 PubMed GONUTS page

[PMID:1643657-20] 20.0 ^20.1 Ridley, AJ & Hall, A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70 389-99 PubMed GONUTS page

[PMID:18824598-21] Ernkvist, M et al. (2009) The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood 113 244-53 PubMed GONUTS page

[PMID:21976490-22] Fisher, D et al. (2011) Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J. Neurosci. 31 14051-66 PubMed GONUTS page

[PMID:14657280-23] Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page

[PMID:18332105-24] Ogata, T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol. Cell. Biol. 28 3424-36 PubMed GONUTS page

[PMID:15093731-25] 25.0 ^25.1 Yonemura, S et al. (2004) Rho localization in cells and tissues. Exp. Cell Res. 295 300-14 PubMed GONUTS page

[PMID:18614015-26] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:15798203-27] Kuwahara, K et al. (2005) Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 25 3173-81 PubMed GONUTS page

[PMID:15249579-28] Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page

[PMID:15860730-29] Pixley, FJ et al. (2005) BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J. Cell. Sci. 118 1873-83 PubMed GONUTS page

[PMID:7888179-30] 30.0 ^30.1 ^30.2 ^30.3 Hall, A (1994) Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol. 10 31-54 PubMed GONUTS page

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