MOUSE:RET

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ret
Protein Name(s)	Proto-oncogene tyrosine-protein kinase receptor Ret Proto-oncogene c-Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
External Links
UniProt	P35546
EMBL	X67812 AF209436 AY326397 AK051633 BC059012
CCDS	CCDS20470.1 CCDS39608.1
PIR	I48735
RefSeq	NP_001074249.1 NP_033076.2
UniGene	Mm.57199
PDB	1UEF
PDBsum	1UEF
ProteinModelPortal	P35546
SMR	P35546
BioGrid	202865
IntAct	P35546
MINT	MINT-5313433
BindingDB	P35546
ChEMBL	CHEMBL2034799
PhosphoSite	P35546
MaxQB	P35546
PRIDE	P35546
Ensembl	ENSMUST00000032201 ENSMUST00000088790
GeneID	19713
KEGG	mmu:19713
UCSC	uc009dlm.1 uc009dln.1
CTD	5979
MGI	MGI:97902
eggNOG	COG0515
GeneTree	ENSGT00760000118923
HOGENOM	HOG000010301
HOVERGEN	HBG002609
InParanoid	P35546
KO	K05126
OMA	SMENQVS
OrthoDB	EOG7NGQ9N
PhylomeDB	P35546
TreeFam	TF317640
BRENDA	2.7.10.1
EvolutionaryTrace	P35546
NextBio	297098
PRO	PR:P35546
Proteomes	UP000000589
Bgee	P35546
CleanEx	MM_RET
Genevestigator	P35546
GO	GO:0010008 GO:0005887 GO:0045121 GO:0043235 GO:0005524 GO:0005509 GO:0004714 GO:0006919 GO:0009653 GO:0071300 GO:0001838 GO:0048484 GO:0007156 GO:0060384 GO:0000165 GO:0033619 GO:0007399 GO:0001755 GO:0007158 GO:0030182 GO:0042551 GO:0018108 GO:0061146 GO:0033630 GO:0030335 GO:0045793 GO:2001241 GO:0072300 GO:0014042 GO:0010976 GO:0045893 GO:0050770 GO:0042493 GO:0048265 GO:0060041 GO:0007169 GO:0035799 GO:0001657
Gene3D	2.60.40.60
InterPro	IPR002126 IPR015919 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 IPR016249
Pfam	PF00028 PF07714
PIRSF	PIRSF000631
PRINTS	PR00109
SMART	SM00112 SM00219
SUPFAM	SSF49313 SSF56112
PROSITE	PS50268 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033690	positive regulation of osteoblast proliferation	PMID:23969857^[1]	ECO:0000314			P		Fig. 1B	complete CACAO 8625
	GO:0043066	negative regulation of apoptotic process	PMID:23969857^[1]	ECO:0000314			P		Fig. 1G	complete CACAO 8647
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:28846099^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
involved_in	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
involved_in	GO:0072300	positive regulation of metanephric glomerulus development	PMID:17047028^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061146	Peyer's patch morphogenesis	PMID:17322904^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048265	response to pain	PMID:20237269^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17047028^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	PMID:21357690^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(UniProtKB:P15116)	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521373 UniProtKB:P07949	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521373 UniProtKB:P07949	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002521374 RGD:3556	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011829 MGI:MGI:97902 PANTHER:PTN002521432 RGD:3556 UniProtKB:P07949 ZFIN:ZDB-GENE-980526-307	P		Seeded From UniProt	complete
involved_in	GO:0022008	neurogenesis	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011829 MGI:MGI:97902 PANTHER:PTN002521373 RGD:3556 UniProtKB:P07949	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011829 MGI:MGI:97902 PANTHER:PTN002521373 RGD:3556 UniProtKB:P07949 ZFIN:ZDB-GENE-980526-307	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
part_of	GO:0098797	plasma membrane protein complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071300	cellular response to retinoic acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060384	innervation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050770	regulation of axonogenesis	PMID:17553423^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:4413350	P	regulates_o_occurs_in:(EMAPA:16665) regulates_o_occurs_in:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048484	enteric nervous system development	PMID:9834195^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136894	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045793	positive regulation of cell size	PMID:17553423^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:4413350	P	regulates_o_occurs_in:(EMAPA:16668) regulates_o_occurs_in:(CL:0000198)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:23382219^[10]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042551	neuron maturation	PMID:15233745^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136894	P	occurs_in:(EMAPA:18439) results_in_maturation_of:(CL:0000108)\|occurs_in(EMAPA:18439) results_in_maturation_of:(CL:0000108)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035799	ureter maturation	PMID:21521737^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136894	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033619	membrane protein proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:23872421^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000031)	Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:17553423^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386570,MGI:MGI:4413350	P	occurs_in:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014042	positive regulation of neuron maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:22897442^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:22897442^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3819163	P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:11069590^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136894	P	results_in_development_of:(EMAPA:18221)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:9576965^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108417 MGI:MGI:1195462	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007158	neuron cell-cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3556	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001838	embryonic epithelial tube formation	PMID:15569713^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1930016	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001755	neural crest cell migration	PMID:15242795^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449909	P	occurs_in:(EMAPA:16833) results_in_movement_of:(CL:0000333)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001657	ureteric bud development	PMID:12195422^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2136894	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:15569713^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1930016	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0060384	innervation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	C		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	C		Seeded From UniProt	complete
involved_in	GO:0014042	positive regulation of neuron maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V9H8 ensembl:ENSRNOP00000047793	C		Seeded From UniProt	complete
part_of	GO:0098797	plasma membrane protein complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
involved_in	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0033619	membrane protein proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
involved_in	GO:0007158	neuron cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	F		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07949 ensembl:ENSP00000347942	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7T2 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7T2 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R7T2 ensembl:ENSP00000347942	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002126 InterPro:IPR015919	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0033139	regulation of peptidyl-serine phosphorylation of STAT protein	PMID:23872421^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:23872421^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001838	embryonic epithelial tube formation	PMID:15569713^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009653	anatomical structure morphogenesis	PMID:11731455^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_participant:(EMAPA:17209)	Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:11731455^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0010008	endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0100	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Khedgikar, V et al. (2013) Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death Dis 4 e778 PubMed GONUTS page
↑ Yang, L et al. (2017) GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat. Med. 23 1158-1166 PubMed GONUTS page
↑ ^3.0 ^3.1 Clarke, JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15 3420-8 PubMed GONUTS page
↑ Veiga-Fernandes, H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446 547-51 PubMed GONUTS page
↑ Golden, JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J. Neurosci. 30 3983-94 PubMed GONUTS page
↑ Cabrera, JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J. Biol. Chem. 286 14628-38 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Luo, W et al. (2007) A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54 739-54 PubMed GONUTS page
↑ Natarajan, D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126 157-68 PubMed GONUTS page
↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
↑ Burau, K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur. J. Neurosci. 20 353-62 PubMed GONUTS page
↑ Chia, I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138 2089-97 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Zhou, L & Too, HP (2013) GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET. Biochim. Biophys. Acta 1833 2789-2802 PubMed GONUTS page
↑ ^14.0 ^14.1 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page
↑ Rossi, J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur. J. Neurosci. 12 3944-52 PubMed GONUTS page
↑ Baloh, RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. U.S.A. 95 5801-6 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page
↑ Yan, H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev. Biol. 272 118-33 PubMed GONUTS page
↑ Batourina, E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat. Genet. 32 109-15 PubMed GONUTS page
↑ ^20.0 ^20.1 Brophy, PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128 4747-56 PubMed GONUTS page

[PMID:23969857-1] 1.0 ^1.1 Khedgikar, V et al. (2013) Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death Dis 4 e778 PubMed GONUTS page

[PMID:28846099-2] Yang, L et al. (2017) GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand. Nat. Med. 23 1158-1166 PubMed GONUTS page

[PMID:17047028-3] 3.0 ^3.1 Clarke, JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum. Mol. Genet. 15 3420-8 PubMed GONUTS page

[PMID:17322904-4] Veiga-Fernandes, H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature 446 547-51 PubMed GONUTS page

[PMID:20237269-5] Golden, JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J. Neurosci. 30 3983-94 PubMed GONUTS page

[PMID:21357690-6] Cabrera, JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J. Biol. Chem. 286 14628-38 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 ^7.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17553423-8] 8.0 ^8.1 ^8.2 Luo, W et al. (2007) A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron 54 739-54 PubMed GONUTS page

[PMID:9834195-9] Natarajan, D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development 126 157-68 PubMed GONUTS page

[PMID:23382219-10] Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page

[PMID:15233745-11] Burau, K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur. J. Neurosci. 20 353-62 PubMed GONUTS page

[PMID:21521737-12] Chia, I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development 138 2089-97 PubMed GONUTS page

[PMID:23872421-13] 13.0 ^13.1 ^13.2 Zhou, L & Too, HP (2013) GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRα2 and RET. Biochim. Biophys. Acta 1833 2789-2802 PubMed GONUTS page

[PMID:22897442-14] 14.0 ^14.1 Evangelisti, C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol. Motil. 24 e497-508 PubMed GONUTS page

[PMID:11069590-15] Rossi, J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur. J. Neurosci. 12 3944-52 PubMed GONUTS page

[PMID:9576965-16] Baloh, RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. U.S.A. 95 5801-6 PubMed GONUTS page

[PMID:15569713-17] 17.0 ^17.1 ^17.2 Schuetz, G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J. Cell Biol. 167 945-52 PubMed GONUTS page

[PMID:15242795-18] Yan, H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev. Biol. 272 118-33 PubMed GONUTS page

[PMID:12195422-19] Batourina, E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat. Genet. 32 109-15 PubMed GONUTS page

[PMID:11731455-20] 20.0 ^20.1 Brophy, PD et al. (2001) Regulation of ureteric bud outgrowth by Pax2-dependent activation of the glial derived neurotrophic factor gene. Development 128 4747-56 PubMed GONUTS page

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