MOUSE:RAC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Rac1
Protein Name(s)	Ras-related C3 botulinum toxin substrate 1 p21-Rac1
External Links
UniProt	P63001
EMBL	X57277 AK009017 AK011072 AK034601 AK047969 AK088825 BC003828 BC051053
CCDS	CCDS19843.1
PIR	A60347
RefSeq	NP_033033.1
UniGene	Mm.292510 Mm.469963 Mm.475073
ProteinModelPortal	P63001
SMR	P63001
BioGrid	202556
DIP	DIP-31545N
IntAct	P63001
MINT	MINT-1602774
STRING	10090.ENSMUSP00000079380
BindingDB	P63001
ChEMBL	CHEMBL5628
PhosphoSite	P63001
MaxQB	P63001
PaxDb	P63001
PRIDE	P63001
GeneID	19353
KEGG	mmu:19353
UCSC	uc009akk.1
CTD	5879
MGI	MGI:97845
eggNOG	COG1100
HOGENOM	HOG000233974
HOVERGEN	HBG009351
InParanoid	P63001
KO	K04392
OrthoDB	EOG764747
PhylomeDB	P63001
TreeFam	TF101109
Reactome	R-MMU-114604 R-MMU-1433557 R-MMU-1445148 R-MMU-193648 R-MMU-194840 R-MMU-2029482 R-MMU-2424491 R-MMU-2871796 R-MMU-376172 R-MMU-389359 R-MMU-3928662 R-MMU-3928664 R-MMU-3928665 R-MMU-399954 R-MMU-399955 R-MMU-4086400 R-MMU-416482 R-MMU-416550 R-MMU-416572 R-MMU-418885 R-MMU-428540 R-MMU-428543 R-MMU-4420097 R-MMU-445144 R-MMU-5218920 R-MMU-5625900 R-MMU-5625970 R-MMU-5626467 R-MMU-5627123 R-MMU-5663213 R-MMU-5663220 R-MMU-5668599 R-MMU-5687128 R-MMU-983231
ChiTaRS	Rac1
NextBio	296387
PRO	PR:P63001
Proteomes	UP000000589
Bgee	P63001
CleanEx	MM_RAC1
ExpressionAtlas	P63001
Genevisible	P63001
GO	GO:0005884 GO:0042995 GO:0005737 GO:0016023 GO:0036464 GO:0005829 GO:0031901 GO:0070062 GO:0019897 GO:0005925 GO:0030027 GO:0042470 GO:0016020 GO:0005634 GO:0001891 GO:0005886 GO:0032587 GO:0005802 GO:0019899 GO:0005525 GO:0030742 GO:0003924 GO:0051022 GO:0031996 GO:0030036 GO:0030041 GO:0048532 GO:0002093 GO:0007411 GO:0007155 GO:0016477 GO:0048870 GO:0045216 GO:0021894 GO:0021799 GO:0090103 GO:0007010 GO:0016358 GO:0048813 GO:0071542 GO:0021831 GO:0006897 GO:0043652 GO:0003382 GO:0007186 GO:0048873 GO:0006972 GO:0030032 GO:0051668 GO:0032707 GO:0006911 GO:0030838 GO:0010811 GO:0051894 GO:0010592 GO:0090023 GO:0043552 GO:0001934 GO:0051496 GO:1900026 GO:0072659 GO:0030334 GO:0022604 GO:0010762 GO:0014041 GO:0060263 GO:0097178 GO:0031529 GO:0071526 GO:0007264 GO:0034446 GO:0051932 GO:0060071
Gene3D	3.40.50.300
InterPro	IPR027417 IPR005225 IPR001806 IPR003578
Pfam	PF00071
SMART	SM00174
SUPFAM	SSF52540
TIGRFAMs	TIGR00231
PROSITE	PS51420

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0061344	regulation of cell adhesion involved in heart morphogenesis	PMID:25514037^[1]	ECO:0000315			P		Figure 3 shows cell adhesion defects in Rac1-cKO mice. "The observed adhesion defects are manifested only after E12.5 even though cardiomyocytes differentiate and start contracting few days earlier at E8.5... The ‘in vitro’ results demonstrate that cardiomyocytes present adhesion defects at E11.5, however, cardiomyocyte adhesion is not completely abolished as these cells still do weakly adhere to the substrate and one another. This suggests that Rac1 is not required for initial adhesion, but is needed for enhancement and maturation of adhesive properties of cardiomyocytes when the heart beating begins to carry higher loads at E12.5 and beyond."	complete CACAO 11086
	GO:0007262	STAT protein import into nucleus	PMID:27050391^[2]	ECO:0000315			P		Figure 5B showed a decrease in p-STAT3 at tyrosine 705 ( with present of Rac inhibitor) compared to the control and Figure 5C showed a decrease in staining around the nuclear when Rac- specific inhibitor was presented. aka inhibition of Rac resulted in less phosphorylated STAT3 or down-regulated nuclear import. So Rac1 regulates STAT3 activity by affecting nuclear STAT3 phosphorylation level	complete CACAO 11576
	GO:2000386	positive regulation of ovarian follicle development	PMID:27050391^[2]	ECO:0000315			P		Figure 1E,F	complete CACAO 11578
	GO:0043073	germ cell nucleus	PMID:27050391^[2]	ECO:0000314			C		Figure 1A shows immunostaining of Rac1 in the nucleus of germ cells.	complete CACAO 11582
	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:23412604^[3]	ECO:0000315			P		Mus, Ras-related C3 botulinum toxin substrate 1 (RAC1) In Figure 5d and 5e, perfusion analysis was used to show how RAC1 deficiency in mouse cells resulted in the second phase of insulin secretion being greatly decreased. This shows that RAC1 must be involved in the positive regulation of insulin secretion in response to glucose stimulus, which is the second phase of insulin secretion.	complete CACAO 12943
part_of	GO:0030027	lamellipodium	PMID:22959435^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:22959435^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	PMID:18953410^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	PMID:19007770^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048812	neuron projection morphogenesis	PMID:21483795^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22725	P	occurs_in:(CL:0000700) occurs_in:(UBERON:0001891)	Seeded From UniProt	complete
involved_in	GO:0035567	non-canonical Wnt signaling pathway	PMID:21483795^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P22725	P	occurs_in:(CL:0000700) occurs_in:(UBERON:0001891) part_of:(GO:0048812)	Seeded From UniProt	complete
involved_in	GO:1904948	midbrain dopaminergic neuron differentiation	PMID:23109420^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010762	regulation of fibroblast migration	PMID:25074804^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:25074804^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	PMID:25074804^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25074804^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:25074804^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0090023	positive regulation of neutrophil chemotaxis	PMID:19625648^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	PMID:19625648^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0030593)	Seeded From UniProt	complete
involved_in	GO:0043652	engulfment of apoptotic cell	PMID:20691665^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097178	ruffle assembly	PMID:10934045^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6RUV5	P		Seeded From UniProt	complete
enables	GO:0051022	Rho GDP-dissociation inhibitor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6RUV5	F		Seeded From UniProt	complete
involved_in	GO:0048870	cell motility	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	PMID:10934045^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030742	GTP-dependent protein binding	PMID:10954424^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z101	F		Seeded From UniProt	complete
involved_in	GO:0006911	phagocytosis, engulfment	PMID:10934045^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6RUV5	C		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	PMID:10934045^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902622	regulation of neutrophil migration	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN002374567 UniProtKB:P15153 UniProtKB:P63000 ZFIN:ZDB-GENE-040625-27	P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000633314 RGD:619755 UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 MGI:MGI:97845 PANTHER:PTN002784637 RGD:619755 UniProtKB:P15153 UniProtKB:P63000 WB:WBGene00004287	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97845 PANTHER:PTN002784637 RGD:619755 UniProtKB:P63000 WB:WBGene00000424 dictyBase:DDB_G0293526	C		Seeded From UniProt	complete
involved_in	GO:0030036	actin cytoskeleton organization	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0014011 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN002784637 RGD:1307568 RGD:619755 UniProtKB:P15153 UniProtKB:P63000 UniProtKB:Q6LC82 WB:WBGene00004287	P		Seeded From UniProt	complete
involved_in	GO:0030031	cell projection assembly	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97846 PANTHER:PTN002374567	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0014011 PANTHER:PTN002784637 RGD:619755 UniProtKB:P63000 dictyBase:DDB_G0293526	F		Seeded From UniProt	complete
involved_in	GO:0016601	Rac protein signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002374567 RGD:619755	P		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0014011 MGI:MGI:97845 PANTHER:PTN002784637 RGD:619755 UniProtKB:Q6LC82 WB:WBGene00000424 WB:WBGene00004287 ZFIN:ZDB-GENE-030131-5415 ZFIN:ZDB-GENE-040625-27 dictyBase:DDB_G0293526	P		Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 PANTHER:PTN002784640 WB:WBGene00000424 WB:WBGene00004287	P		Seeded From UniProt	complete
involved_in	GO:0007266	Rho protein signal transduction	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010341 FB:FBgn0014011 MGI:MGI:1931551 PANTHER:PTN000632671 RGD:619921 UniProtKB:I3LVS7 UniProtKB:P61586 UniProtKB:P84095	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 MGI:MGI:97845 PANTHER:PTN002784637 UniProtKB:P63000 WB:WBGene00000424 WB:WBGene00004287	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN002784637 RGD:619755 UniProtKB:P15153 UniProtKB:P63000 WB:WBGene00000424 ZFIN:ZDB-GENE-040625-27 dictyBase:DDB_G0280975 dictyBase:DDB_G0293526	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0039140 MGI:MGI:108446 MGI:MGI:97845 PANTHER:PTN000632671 RGD:619755 RGD:619921 RGD:71043 SGD:S000001380 TAIR:locus:2131606 TAIR:locus:2204380 UniProtKB:A0A1D8PDV5 UniProtKB:P15153 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:Q15669 UniProtKB:Q9SSX0 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010333 FB:FBgn0010341 FB:FBgn0014011 FB:FBgn0014020 MGI:MGI:106211 MGI:MGI:1096342 MGI:MGI:1916831 MGI:MGI:97845 MGI:MGI:97846 PANTHER:PTN000632671 PomBase:SPAC110.03 PomBase:SPAC16.01 PomBase:SPAC16A10.04 PomBase:SPAC1F7.04 PomBase:SPAC23C4.08 RGD:619755 RGD:619921 SGD:S000000046 SGD:S000001380 SGD:S000001763 SGD:S000004219 SGD:S000005034 SGD:S000005124 SGD:S000006369 TAIR:locus:2099232 TAIR:locus:2131606 UniProtKB:A0A1D8PCX9 UniProtKB:A0A1D8PH96 UniProtKB:P17081 UniProtKB:P60763 UniProtKB:P60953 UniProtKB:P61586 UniProtKB:P63000 UniProtKB:P84095 UniProtKB:Q5A904 WB:WBGene00000390 WB:WBGene00000424 WB:WBGene00003239 WB:WBGene00004287 WB:WBGene00004357	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097178	ruffle assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090103	cochlea morphogenesis	PMID:20016102^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663662 MGI:MGI:2663669	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090023	positive regulation of neutrophil chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072659	protein localization to plasma membrane	PMID:23184663^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	transports_or_maintains_localization_of:(UniProtKB:Q9Z206-2)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	PMID:18953410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	PMID:25865668^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2685385	P	occurs_in:(EMAPA:35790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	PMID:25865668^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:35790)\|occurs_in:(EMAPA:35790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060263	regulation of respiratory burst	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0060091	kinocilium	PMID:23533177^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000589) part_of:(EMAPA:17597)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	PMID:18953410^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98958	P		Seeded From UniProt	complete
part_of	GO:0055038	recycling endosome membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051932	synaptic transmission, GABAergic	PMID:23258346^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2180784	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051668	localization within membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051492	regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
enables	GO:0051117	ATPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
enables	GO:0051022	Rho GDP-dissociation inhibitor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048873	homeostasis of number of cells within a tissue	PMID:23258346^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2180784	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048870	cell motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048813	dendrite morphogenesis	PMID:20335472^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1891740	P	occurs_in:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048532	anatomical structure arrangement	PMID:20016102^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663662 MGI:MGI:2663669	P	occurs_in:(EMAPA:19151)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	PMID:25865668^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2685385	P	occurs_in:(EMAPA:35790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048168	regulation of neuronal synaptic plasticity	PMID:25865668^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(EMAPA:35790)\|occurs_in:(EMAPA:35790)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045453	bone resorption	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045428	regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045216	cell-cell junction organization	PMID:20016102^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663662 MGI:MGI:2663669	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:15728722^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	PMID:15728722^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
part_of	GO:0036464	cytoplasmic ribonucleoprotein granule	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	PMID:18156211^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032707	negative regulation of interleukin-23 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
enables	GO:0031996	thioesterase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031529	ruffle organization	PMID:15467718^[23]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:14516655^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036) part_of:(CL:0000007)\|part_of:(EMAPA:16037) part_of:(CL:0000007)\|part_of:(EMAPA:16040) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:12783890^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030838	positive regulation of actin filament polymerization	PMID:12853475^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	PMID:17409253^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932522,MGI:MGI:2663662	P	regulates_o_occurs_in:(EMAPA:19041) regulates_o_results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030334	regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030041	actin filament polymerization	PMID:22750946^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030036	actin cytoskeleton organization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030032	lamellipodium assembly	PMID:15728191^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030032	lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:14657280^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	PMID:12783890^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022604	regulation of cell morphogenesis	PMID:23258346^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2180784	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021894	cerebral cortex GABAergic interneuron development	PMID:23258346^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2180784	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021831	embryonic olfactory bulb interneuron precursor migration	PMID:17409253^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932522,MGI:MGI:2663662	P	occurs_in:(EMAPA:17778) results_in_movement_of:(CL:0000402)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021799	cerebral cortex radially oriented cell migration	PMID:17409253^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932522,MGI:MGI:2663662	P	occurs_in:(EMAPA:19041) results_in_movement_of:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
part_of	GO:0019897	extrinsic component of plasma membrane	PMID:14516655^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16036) part_of:(CL:0000007)\|part_of:(EMAPA:16037) part_of:(CL:0000007)	Seeded From UniProt	complete
enables	GO:0017137	Rab GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016601	Rac protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15728191^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:12213441^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:14657280^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014041	regulation of neuron maturation	PMID:23258346^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2180784	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010811	positive regulation of cell-substrate adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	PMID:15467718^[23]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010592	positive regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010591	regulation of lamellipodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008361	regulation of cell size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:17409253^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1932522,MGI:MGI:2663662	P	occurs_in:(EMAPA:17544)\|occurs_in:(EMAPA:17549)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007264	small GTPase mediated signal transduction	PMID:23967341^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007264	small GTPase mediated signal transduction	PMID:12525493^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	PMID:21178006^[34]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:3040696 MGI:MGI:98923	P	occurs_in:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007155	cell adhesion	PMID:14657280^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007015	actin filament organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007010	cytoskeleton organization	PMID:14657280^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006972	hyperosmotic response	PMID:12783890^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006935	chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006897	endocytosis	PMID:12446704^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
colocalizes_with	GO:0005884	actin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12213441^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:23528453^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:15728191^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:14580336^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:12783890^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:23620790^[38]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	PMID:15467718^[23]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:15249579^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:12525493^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:10699171^[40]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003382	epithelial cell morphogenesis	PMID:20016102^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663662 MGI:MGI:2663669	P	results_in_morphogenesis_of:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002551	mast cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002093	auditory receptor cell morphogenesis	PMID:20016102^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2663662 MGI:MGI:2663669	P	results_in_morphogenesis_of:(CL:0000589)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P63000	P		Seeded From UniProt	complete
part_of	GO:0000242	pericentriolar material	PMID:23533177^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000589) part_of:(EMAPA:17597)	Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619755	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001806 InterPro:IPR003578 InterPro:IPR005225	F		Seeded From UniProt	complete
involved_in	GO:0007264	small GTPase mediated signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003578	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-9033341 Reactome:R-MMU-8981447 Reactome:R-MMU-5665656 Reactome:R-MMU-5663241 Reactome:R-MMU-5625893 Reactome:R-MMU-421148 Reactome:R-MMU-421147 Reactome:R-MMU-421144 Reactome:R-MMU-421142	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030032	lamellipodium assembly	PMID:12351724^[41]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0042470	melanosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0161	C		Seeded From UniProt	complete
part_of	GO:0030027	lamellipodium	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0291	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Abu-Issa, R (2015) Rac1 modulates cardiomyocyte adhesion during mouse embryonic development. Biochem. Biophys. Res. Commun. 456 847-52 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page
↑ Asahara, S et al. (2013) Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia 56 1088-97 PubMed GONUTS page
↑ ^4.0 ^4.1 Yang, T et al. (2012) POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Rep 2 640-51 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Andersson, ER et al. (2008) Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE 3 e3517 PubMed GONUTS page
↑ Chen, L et al. (2009) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev. Biol. 325 162-70 PubMed GONUTS page
↑ ^7.0 ^7.1 Blakely, BD et al. (2011) Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE 6 e18373 PubMed GONUTS page
↑ Čajánek, L et al. (2013) Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33 59-70 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Williamson, RC et al. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J. Cell. Sci. 127 4292-307 PubMed GONUTS page
↑ ^10.0 ^10.1 Zhang, H et al. (2009) Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J. Immunol. 183 2718-28 PubMed GONUTS page
↑ Tanaka, T et al. (2010) Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. Biochem. Biophys. Res. Commun. 399 677-82 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Ohsawa, K et al. (2000) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J. Cell. Sci. 113 ( Pt 17) 3073-84 PubMed GONUTS page
↑ Johansson, A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18) 3267-75 PubMed GONUTS page
↑ ^14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page
↑ Carr, HS et al. (2013) Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreading. Mol. Cell. Biol. 33 622-34 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Lu, J et al. (2015) A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun 6 6820 PubMed GONUTS page
↑ ^18.0 ^18.1 Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Vaghi, V et al. (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb. Cortex 24 1247-58 PubMed GONUTS page
↑ Okerlund, ND et al. (2010) Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J. Neurosci. 30 4362-8 PubMed GONUTS page
↑ ^21.0 ^21.1 Aoki, K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16 2207-17 PubMed GONUTS page
↑ Dufourcq, P et al. (2008) Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am. J. Pathol. 172 37-49 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page
↑ ^24.0 ^24.1 Natale, DR & Watson, AJ (2002) Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Mech. Dev. 119 Suppl 1 S21-6 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 Torbett, NE et al. (2003) Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. J. Biol. Chem. 278 32344-51 PubMed GONUTS page
↑ Yan, C et al. (2003) WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 22 3602-12 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 ^27.3 Chen, L et al. (2007) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J. Neurosci. 27 3884-93 PubMed GONUTS page
↑ Galic, M et al. (2012) External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat. Cell Biol. 14 874-81 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Pratt, SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168 813-24 PubMed GONUTS page
↑ ^30.0 ^30.1 ^30.2 ^30.3 Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page
↑ ^31.0 ^31.1 Hayashi, K et al. (2002) Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons. Mol. Cell. Neurosci. 20 579-94 PubMed GONUTS page
↑ Pu, J et al. (2013) FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling. PLoS ONE 8 e73108 PubMed GONUTS page
↑ ^33.0 ^33.1 Baumeister, MA et al. (2003) Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J. Biol. Chem. 278 11457-64 PubMed GONUTS page
↑ Lawson, CD et al. (2011) P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J. Immunol. 186 1467-76 PubMed GONUTS page
↑ Sun, P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J. Biol. Chem. 278 4063-71 PubMed GONUTS page
↑ Gustafsson, K et al. (2013) The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp. Cell Res. 319 1852-64 PubMed GONUTS page
↑ Kissil, JL et al. (2003) Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol. Cell 12 841-9 PubMed GONUTS page
↑ Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page
↑ Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page
↑ Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page
↑ Kubo, T et al. (2002) A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J. Neurosci. 22 8504-13 PubMed GONUTS page

[PMID:25514037-1] Abu-Issa, R (2015) Rac1 modulates cardiomyocyte adhesion during mouse embryonic development. Biochem. Biophys. Res. Commun. 456 847-52 PubMed GONUTS page

[PMID:27050391-2] 2.0 ^2.1 ^2.2 Zhao, L et al. (2016) Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep 6 23972 PubMed GONUTS page

[PMID:23412604-3] Asahara, S et al. (2013) Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Diabetologia 56 1088-97 PubMed GONUTS page

[PMID:22959435-4] 4.0 ^4.1 Yang, T et al. (2012) POSH localizes activated Rac1 to control the formation of cytoplasmic dilation of the leading process and neuronal migration. Cell Rep 2 640-51 PubMed GONUTS page

[PMID:18953410-5] 5.0 ^5.1 ^5.2 Andersson, ER et al. (2008) Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE 3 e3517 PubMed GONUTS page

[PMID:19007770-6] Chen, L et al. (2009) Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly. Dev. Biol. 325 162-70 PubMed GONUTS page

[PMID:21483795-7] 7.0 ^7.1 Blakely, BD et al. (2011) Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS ONE 6 e18373 PubMed GONUTS page

[PMID:23109420-8] Čajánek, L et al. (2013) Tiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neurons. Mol. Cell. Biol. 33 59-70 PubMed GONUTS page

[PMID:25074804-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Williamson, RC et al. (2014) Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure. J. Cell. Sci. 127 4292-307 PubMed GONUTS page

[PMID:19625648-10] 10.0 ^10.1 Zhang, H et al. (2009) Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J. Immunol. 183 2718-28 PubMed GONUTS page

[PMID:20691665-11] Tanaka, T et al. (2010) Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation. Biochem. Biophys. Res. Commun. 399 677-82 PubMed GONUTS page

[PMID:10934045-12] 12.0 ^12.1 ^12.2 ^12.3 Ohsawa, K et al. (2000) Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. J. Cell. Sci. 113 ( Pt 17) 3073-84 PubMed GONUTS page

[PMID:10954424-13] Johansson, A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J. Cell. Sci. 113 ( Pt 18) 3267-75 PubMed GONUTS page

[PMID:21873635-14] 14.00 ^14.01 ^14.02 ^14.03 ^14.04 ^14.05 ^14.06 ^14.07 ^14.08 ^14.09 ^14.10 ^14.11 ^14.12 ^14.13 ^14.14 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20016102-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Grimsley-Myers, CM et al. (2009) The small GTPase Rac1 regulates auditory hair cell morphogenesis. J. Neurosci. 29 15859-69 PubMed GONUTS page

[PMID:23184663-16] Carr, HS et al. (2013) Rac1 controls the subcellular localization of the Rho guanine nucleotide exchange factor Net1A to regulate focal adhesion formation and cell spreading. Mol. Cell. Biol. 33 622-34 PubMed GONUTS page

[PMID:25865668-17] 17.0 ^17.1 ^17.2 ^17.3 Lu, J et al. (2015) A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses. Nat Commun 6 6820 PubMed GONUTS page

[PMID:23533177-18] 18.0 ^18.1 Sipe, CW et al. (2013) Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization. Development 140 1785-95 PubMed GONUTS page

[PMID:23258346-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Vaghi, V et al. (2014) Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb. Cortex 24 1247-58 PubMed GONUTS page

[PMID:20335472-20] Okerlund, ND et al. (2010) Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain. J. Neurosci. 30 4362-8 PubMed GONUTS page

[PMID:15728722-21] 21.0 ^21.1 Aoki, K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol. Biol. Cell 16 2207-17 PubMed GONUTS page

[PMID:18156211-22] Dufourcq, P et al. (2008) Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am. J. Pathol. 172 37-49 PubMed GONUTS page

[PMID:15467718-23] 23.0 ^23.1 ^23.2 Jacinto, E et al. (2004) Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 1122-8 PubMed GONUTS page

[PMID:14516655-24] 24.0 ^24.1 Natale, DR & Watson, AJ (2002) Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Mech. Dev. 119 Suppl 1 S21-6 PubMed GONUTS page

[PMID:12783890-25] 25.0 ^25.1 ^25.2 ^25.3 Torbett, NE et al. (2003) Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. J. Biol. Chem. 278 32344-51 PubMed GONUTS page

[PMID:12853475-26] Yan, C et al. (2003) WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 22 3602-12 PubMed GONUTS page

[PMID:17409253-27] 27.0 ^27.1 ^27.2 ^27.3 Chen, L et al. (2007) Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J. Neurosci. 27 3884-93 PubMed GONUTS page

[PMID:22750946-28] Galic, M et al. (2012) External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat. Cell Biol. 14 874-81 PubMed GONUTS page

[PMID:15728191-29] 29.0 ^29.1 ^29.2 Pratt, SJ et al. (2005) The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J. Cell Biol. 168 813-24 PubMed GONUTS page

[PMID:14657280-30] 30.0 ^30.1 ^30.2 ^30.3 Gavard, J et al. (2004) Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways. J. Cell. Sci. 117 257-70 PubMed GONUTS page

[PMID:12213441-31] 31.0 ^31.1 Hayashi, K et al. (2002) Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons. Mol. Cell. Neurosci. 20 579-94 PubMed GONUTS page

[PMID:23967341-32] Pu, J et al. (2013) FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling. PLoS ONE 8 e73108 PubMed GONUTS page

[PMID:12525493-33] 33.0 ^33.1 Baumeister, MA et al. (2003) Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting. J. Biol. Chem. 278 11457-64 PubMed GONUTS page

[PMID:21178006-34] Lawson, CD et al. (2011) P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J. Immunol. 186 1467-76 PubMed GONUTS page

[PMID:12446704-35] Sun, P et al. (2003) Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation. J. Biol. Chem. 278 4063-71 PubMed GONUTS page

[PMID:23528453-36] Gustafsson, K et al. (2013) The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp. Cell Res. 319 1852-64 PubMed GONUTS page

[PMID:14580336-37] Kissil, JL et al. (2003) Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol. Cell 12 841-9 PubMed GONUTS page

[PMID:23620790-38] Chiang, YJ et al. (2013) CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE 8 e61761 PubMed GONUTS page

[PMID:15249579-39] Gakidis, MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J. Cell Biol. 166 273-82 PubMed GONUTS page

[PMID:10699171-40] Prakash, SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum. Mol. Genet. 9 477-88 PubMed GONUTS page

[PMID:12351724-41] Kubo, T et al. (2002) A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J. Neurosci. 22 8504-13 PubMed GONUTS page

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MOUSE:RAC1

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