MOUSE:Q6DR99

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	No Information Provided.
Protein Name(s)	Neuregulin 1 (ECO:0000313 with EMBL:AAI51114.1) Neuregulin-1 type III beta1-a (ECO:0000313 with EMBL:AAT68240.1) Protein Nrg1 (ECO:0000313 with Ensembl:ENSMUSP00000073546)
External Links
UniProt	Q6DR99
EMBL	AC127374 AC132407 BC151113 AY648975
RefSeq	NP_848706.2
UniGene	Mm.153432 Mm.460675
STRING	10090.ENSMUSP00000073546
DNASU	211323
Ensembl	ENSMUST00000073884
GeneID	211323
KEGG	mmu:211323
UCSC	uc009ljo.1
CTD	3084
MGI	MGI:96083
eggNOG	ENOG410IEU9 ENOG4110ST7
GeneTree	ENSGT00800000124099
HOGENOM	HOG000273863
HOVERGEN	HBG006531
KO	K05455
OMA	LEMDSNA
OrthoDB	EOG7F7W86
TreeFam	TF332469
Reactome	R-MMU-1227986 R-MMU-1236394 R-MMU-1250196 R-MMU-1250342 R-MMU-1250347 R-MMU-1257604 R-MMU-1306955 R-MMU-1358803 R-MMU-1963640 R-MMU-1963642 R-MMU-5673001
NextBio	373200
PRO	PR:Q6DR99
Proteomes	UP000000589
GO	GO:0016324 GO:0030673 GO:0030424 GO:0044297 GO:0005737 GO:0030425 GO:0009897 GO:0005576 GO:0005615 GO:0005887 GO:0031594 GO:0005634 GO:0005886 GO:0045202 GO:0045499 GO:0005176 GO:0030296 GO:0003712 GO:0007171 GO:0008366 GO:0007420 GO:0003161 GO:0060379 GO:0016477 GO:0000902 GO:0008283 GO:0043624 GO:0021842 GO:0009790 GO:0060956 GO:0038127 GO:0010001 GO:0021781 GO:0015758 GO:0007507 GO:0007626 GO:0000165 GO:0007517 GO:0042552 GO:0010667 GO:2001240 GO:2001223 GO:0042177 GO:0051048 GO:0045892 GO:0007399 GO:0022008 GO:0048663 GO:0045213 GO:0048709 GO:0007422 GO:0045773 GO:0070886 GO:2000727 GO:0060045 GO:0045785 GO:0060999 GO:0031643 GO:0050731 GO:0014068 GO:0045860 GO:0051897 GO:2000010 GO:1903955 GO:0046579 GO:0045944 GO:0008217 GO:0045595 GO:0043497 GO:0001964 GO:0007416 GO:0055012 GO:0003222
InterPro	IPR013032 IPR000742 IPR002154 IPR018250
PANTHER	PTHR11100:SF7
Pfam	PF02158
PRINTS	PR01089
SMART	SM00181
PROSITE	PS00022 PS50026

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2000727	positive regulation of cardiac muscle cell differentiation	PMID:17336907^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:15494726^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001844)	Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	PMID:15494726^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001844)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:20393464^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:20393464^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098982	GABA-ergic synapse	PMID:20393464^[3]	ECO:0001225	knockout evidence used in manual assertion		C	part_of:(UBERON:0001950)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15494726^[2]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0001844)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:15494726^[2]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0001844)	Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:20393464^[3]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:20393464^[3]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0007416	synapse assembly	PMID:20393464^[3]	ECO:0001225	knockout evidence used in manual assertion		P	occurs_in:(GO:0098982) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0001950)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097165 PANTHER:PTN000873337	P		Seeded From UniProt	complete
enables	GO:0030296	protein tyrosine kinase activator activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000120910 UniProtKB:Q02297	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96083 PANTHER:PTN000120898	P		Seeded From UniProt	complete
involved_in	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000120910 UniProtKB:Q02297	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000873337 RGD:621341 UniProtKB:Q02297	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000873337 UniProtKB:Q02297	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001223	negative regulation of neuron migration	PMID:22376909^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade	PMID:19179536^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95411	P	occurs_in:(EMAPA:16668) occurs_in:(CL:0002573)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:20448149^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:8702723^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:21186272^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(PR:Q01279) has_output:(PR:000044844)\|has_input(PR:P70424) has_output:(PR:000044845)\|has_input(PR:Q61527) has_output:(PR:000044846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048738	cardiac muscle tissue development	PMID:24364879^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:11756753^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928489	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:11425901^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046579	positive regulation of Ras protein signal transduction	PMID:8707830^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15073182^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02297	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:7816098^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045860	positive regulation of protein kinase activity	PMID:10597237^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:9892702^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928489	P	regulates_o_occurs_in:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045595	regulation of cell differentiation	PMID:11425901^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0045499	chemorepellent activity	PMID:22376909^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045213	neurotransmitter receptor metabolic process	PMID:9110980^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928489	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	PMID:7816098^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043624	cellular protein complex disassembly	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02297-6	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042177	negative regulation of protein catabolic process	PMID:20448149^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000218)	Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	PMID:7589796^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:7902537^[20]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P43322	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:20220021^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022011	myelination in peripheral nervous system	PMID:25453108^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	PMID:22376909^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021781	glial cell fate commitment	PMID:21068328^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:9247262^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104771	P	results_in_movement_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:24364879^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010001	glial cell differentiation	PMID:16606832^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2447758,MGI:MGI:2447761	P	occurs_in:(EMAPA:35578) results_in_acquisition_of_features_of:(CL:0000218)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010001	glial cell differentiation	PMID:12649319^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928489	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007626	locomotory behavior	PMID:10762692^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928825	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007517	muscle organ development	PMID:12495620^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:9362461^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928825	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:8643489^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928491	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:7477375^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928490	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007422	peripheral nervous system development	PMID:9362461^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928825	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007422	peripheral nervous system development	PMID:7477375^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928490	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:10707974^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928831	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007399	nervous system development	PMID:8643489^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928491	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:11425901^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:9789034^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9789034^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005176	ErbB-2 class receptor binding	PMID:9247262^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104771	F		Seeded From UniProt	complete
enables	GO:0005176	ErbB-2 class receptor binding	PMID:11425901^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	PMID:15073182^[14]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q02297	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003161	cardiac conduction system development	PMID:12149465^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:9247262^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000165	MAPK cascade	PMID:8707830^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061098	positive regulation of protein tyrosine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0030296	P		Seeded From UniProt	complete
involved_in	GO:0060956	endocardial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0060379	cardiac muscle cell myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0051048	negative regulation of secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
enables	GO:0043125	ErbB-3 class receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	F		Seeded From UniProt	complete
involved_in	GO:0038129	ERBB3 signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0032148	activation of protein kinase B activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	F		Seeded From UniProt	complete
enables	GO:0003712	transcription coregulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	F		Seeded From UniProt	complete
involved_in	GO:0003222	ventricular trabecula myocardium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q02297 ensembl:ENSP00000287842	P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018250 InterPro:IPR040180	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018250 InterPro:IPR040180	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000038	ECO:0000323	imported automatically asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031643	positive regulation of myelination	PMID:15044753^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1928489	P	occurs_in:(CL:0000540) occurs_in:(EMAPA:18577)	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Grego-Bessa, J et al. (2007) Notch signaling is essential for ventricular chamber development. Dev. Cell 12 415-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Bao, J et al. (2004) Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat. Neurosci. 7 1250-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Fazzari, P et al. (2010) Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464 1376-80 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Li, H et al. (2012) Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations. Neural Dev 7 10 PubMed GONUTS page
↑ Kao, SC et al. (2009) Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323 651-4 PubMed GONUTS page
↑ ^7.0 ^7.1 Cotter, L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328 1415-8 PubMed GONUTS page
↑ Riese, DJ et al. (1996) The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. J. Biol. Chem. 271 20047-52 PubMed GONUTS page
↑ Lemmens, K et al. (2011) Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am. J. Physiol. Heart Circ. Physiol. 300 H931-42 PubMed GONUTS page
↑ ^10.0 ^10.1 Hao, J et al. (2014) Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem. J. 458 335-41 PubMed GONUTS page
↑ Viehover, A et al. (2001) Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. Dev. Neurosci. 23 377-86 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Calaora, V et al. (2001) Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J. Neurosci. 21 4740-51 PubMed GONUTS page
↑ ^13.0 ^13.1 Tansey, MG et al. (1996) ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J. Cell Biol. 134 465-76 PubMed GONUTS page
↑ ^14.0 ^14.1 Zhang, Y & Hamburger, AW (2004) Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. J. Biol. Chem. 279 26126-33 PubMed GONUTS page
↑ ^15.0 ^15.1 Jo, SA et al. (1995) Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature 373 158-61 PubMed GONUTS page
↑ Balañá, ME et al. (1999) Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas. Oncogene 18 6370-9 PubMed GONUTS page
↑ Vartanian, T et al. (1999) Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc. Natl. Acad. Sci. U.S.A. 96 731-5 PubMed GONUTS page
↑ Sandrock, AW Jr et al. (1997) Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. Science 276 599-603 PubMed GONUTS page
↑ Moscoso, LM et al. (1995) Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev. Biol. 172 158-69 PubMed GONUTS page
↑ Plowman, GD et al. (1993) Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature 366 473-5 PubMed GONUTS page
↑ Ozkaynak, E et al. (2010) Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. J. Neurosci. 30 3857-64 PubMed GONUTS page
↑ Lim, H et al. (2014) Label-free imaging of Schwann cell myelination by third harmonic generation microscopy. Proc. Natl. Acad. Sci. U.S.A. 111 18025-30 PubMed GONUTS page
↑ Nishino, J et al. (2010) Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J. Neurosci. 30 15228-40 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Rio, C et al. (1997) Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19 39-50 PubMed GONUTS page
↑ Jevsek, M et al. (2006) CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc. Natl. Acad. Sci. U.S.A. 103 6374-9 PubMed GONUTS page
↑ Schmid, RS et al. (2003) Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 100 4251-6 PubMed GONUTS page
↑ Gerlai, R et al. (2000) Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav. Brain Res. 109 219-27 PubMed GONUTS page
↑ Hippenmeyer, S et al. (2002) A role for neuregulin1 signaling in muscle spindle differentiation. Neuron 36 1035-49 PubMed GONUTS page
↑ ^29.0 ^29.1 Erickson, SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124 4999-5011 PubMed GONUTS page
↑ ^30.0 ^30.1 Kramer, R et al. (1996) Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc. Natl. Acad. Sci. U.S.A. 93 4833-8 PubMed GONUTS page
↑ ^31.0 ^31.1 Meyer, D & Birchmeier, C (1995) Multiple essential functions of neuregulin in development. Nature 378 386-90 PubMed GONUTS page
↑ Wolpowitz, D et al. (2000) Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron 25 79-91 PubMed GONUTS page
↑ ^33.0 ^33.1 Liu, X et al. (1998) Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc. Natl. Acad. Sci. U.S.A. 95 13024-9 PubMed GONUTS page
↑ Rentschler, S et al. (2002) Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc. Natl. Acad. Sci. U.S.A. 99 10464-9 PubMed GONUTS page
↑ Michailov, GV et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science 304 700-3 PubMed GONUTS page

[PMID:17336907-1] Grego-Bessa, J et al. (2007) Notch signaling is essential for ventricular chamber development. Dev. Cell 12 415-29 PubMed GONUTS page

[PMID:15494726-2] 2.0 ^2.1 ^2.2 ^2.3 Bao, J et al. (2004) Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos. Nat. Neurosci. 7 1250-8 PubMed GONUTS page

[PMID:20393464-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Fazzari, P et al. (2010) Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464 1376-80 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22376909-5] 5.0 ^5.1 ^5.2 Li, H et al. (2012) Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations. Neural Dev 7 10 PubMed GONUTS page

[PMID:19179536-6] Kao, SC et al. (2009) Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science 323 651-4 PubMed GONUTS page

[PMID:20448149-7] 7.0 ^7.1 Cotter, L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328 1415-8 PubMed GONUTS page

[PMID:8702723-8] Riese, DJ et al. (1996) The epidermal growth factor receptor couples transforming growth factor-alpha, heparin-binding epidermal growth factor-like factor, and amphiregulin to Neu, ErbB-3, and ErbB-4. J. Biol. Chem. 271 20047-52 PubMed GONUTS page

[PMID:21186272-9] Lemmens, K et al. (2011) Activation of the neuregulin/ErbB system during physiological ventricular remodeling in pregnancy. Am. J. Physiol. Heart Circ. Physiol. 300 H931-42 PubMed GONUTS page

[PMID:24364879-10] 10.0 ^10.1 Hao, J et al. (2014) Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem. J. 458 335-41 PubMed GONUTS page

[PMID:11756753-11] Viehover, A et al. (2001) Neuregulin: an oligodendrocyte growth factor absent in active multiple sclerosis lesions. Dev. Neurosci. 23 377-86 PubMed GONUTS page

[PMID:11425901-12] 12.0 ^12.1 ^12.2 ^12.3 Calaora, V et al. (2001) Neuregulin signaling regulates neural precursor growth and the generation of oligodendrocytes in vitro. J. Neurosci. 21 4740-51 PubMed GONUTS page

[PMID:8707830-13] 13.0 ^13.1 Tansey, MG et al. (1996) ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway. J. Cell Biol. 134 465-76 PubMed GONUTS page

[PMID:15073182-14] 14.0 ^14.1 Zhang, Y & Hamburger, AW (2004) Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. J. Biol. Chem. 279 26126-33 PubMed GONUTS page

[PMID:7816098-15] 15.0 ^15.1 Jo, SA et al. (1995) Neuregulins are concentrated at nerve-muscle synapses and activate ACh-receptor gene expression. Nature 373 158-61 PubMed GONUTS page

[PMID:10597237-16] Balañá, ME et al. (1999) Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas. Oncogene 18 6370-9 PubMed GONUTS page

[PMID:9892702-17] Vartanian, T et al. (1999) Failure of spinal cord oligodendrocyte development in mice lacking neuregulin. Proc. Natl. Acad. Sci. U.S.A. 96 731-5 PubMed GONUTS page

[PMID:9110980-18] Sandrock, AW Jr et al. (1997) Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo. Science 276 599-603 PubMed GONUTS page

[PMID:7589796-19] Moscoso, LM et al. (1995) Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev. Biol. 172 158-69 PubMed GONUTS page

[PMID:7902537-20] Plowman, GD et al. (1993) Heregulin induces tyrosine phosphorylation of HER4/p180erbB4. Nature 366 473-5 PubMed GONUTS page

[PMID:20220021-21] Ozkaynak, E et al. (2010) Adam22 is a major neuronal receptor for Lgi4-mediated Schwann cell signaling. J. Neurosci. 30 3857-64 PubMed GONUTS page

[PMID:25453108-22] Lim, H et al. (2014) Label-free imaging of Schwann cell myelination by third harmonic generation microscopy. Proc. Natl. Acad. Sci. U.S.A. 111 18025-30 PubMed GONUTS page

[PMID:21068328-23] Nishino, J et al. (2010) Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system. J. Neurosci. 30 15228-40 PubMed GONUTS page

[PMID:9247262-24] 24.0 ^24.1 ^24.2 Rio, C et al. (1997) Neuregulin and erbB receptors play a critical role in neuronal migration. Neuron 19 39-50 PubMed GONUTS page

[PMID:16606832-25] Jevsek, M et al. (2006) CD24 is expressed by myofiber synaptic nuclei and regulates synaptic transmission. Proc. Natl. Acad. Sci. U.S.A. 103 6374-9 PubMed GONUTS page

[PMID:12649319-26] Schmid, RS et al. (2003) Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 100 4251-6 PubMed GONUTS page

[PMID:10762692-27] Gerlai, R et al. (2000) Heregulin, but not ErbB2 or ErbB3, heterozygous mutant mice exhibit hyperactivity in multiple behavioral tasks. Behav. Brain Res. 109 219-27 PubMed GONUTS page

[PMID:12495620-28] Hippenmeyer, S et al. (2002) A role for neuregulin1 signaling in muscle spindle differentiation. Neuron 36 1035-49 PubMed GONUTS page

[PMID:9362461-29] 29.0 ^29.1 Erickson, SL et al. (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124 4999-5011 PubMed GONUTS page

[PMID:8643489-30] 30.0 ^30.1 Kramer, R et al. (1996) Neuregulins with an Ig-like domain are essential for mouse myocardial and neuronal development. Proc. Natl. Acad. Sci. U.S.A. 93 4833-8 PubMed GONUTS page

[PMID:7477375-31] 31.0 ^31.1 Meyer, D & Birchmeier, C (1995) Multiple essential functions of neuregulin in development. Nature 378 386-90 PubMed GONUTS page

[PMID:10707974-32] Wolpowitz, D et al. (2000) Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses. Neuron 25 79-91 PubMed GONUTS page

[PMID:9789034-33] 33.0 ^33.1 Liu, X et al. (1998) Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc. Natl. Acad. Sci. U.S.A. 95 13024-9 PubMed GONUTS page

[PMID:12149465-34] Rentschler, S et al. (2002) Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc. Natl. Acad. Sci. U.S.A. 99 10464-9 PubMed GONUTS page

[PMID:15044753-35] Michailov, GV et al. (2004) Axonal neuregulin-1 regulates myelin sheath thickness. Science 304 700-3 PubMed GONUTS page

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