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PMID:9362461
| Citation |
Erickson, SL, O'Shea, KS, Ghaboosi, N, Loverro, L, Frantz, G, Bauer, M, Lu, LH and Moore, MW (1997) ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development 124:4999-5011 |
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| Abstract |
Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor. We have generated ErbB3-, ErbB2- and heregulin-deficient mice to assess their roles in development and differentiation. Heregulin(-/-) and ErbB2(-/-) embryos died on E10.5 due to a lack of cardiac ventricular myocyte differentiation; ErbB3(-/-) embryos survived until E13.5 exhibiting cardiac cushion abnormalities leading to blood reflux through defective valves. In ErbB3(-/-) embryos, the midbrain/hindbrain region was strikingly affected, with little differentiation of the cerebellar plate. Cranial ganglia defects, while present in all three nulls, were less severe in ErbB3(-/-) embryos. The cranial ganglia defects, along with a dramatic reduction in Schwann cells, enteric ganglia and adrenal chromaffin cells, suggests a generalized effect on the neural crest. Numerous organs, including the stomach and pancreas also exhibited anomalous development. |
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| Keywords |
Adrenal Glands/embryology; Amino Acid Sequence; Animals; Cell Differentiation; Cerebellum/embryology; Epithelium/embryology; Ganglia/embryology; Gene Expression Regulation, Developmental; Gene Targeting; Glycoproteins/genetics; Glycoproteins/physiology; Heart/embryology; Homeodomain Proteins/analysis; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Pancreas/embryology; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; RNA, Messenger/analysis; Rats; Receptor, Epidermal Growth Factor/physiology; Receptor, erbB-2/physiology; Receptor, erbB-3; Stomach/embryology; Transcription Factors; Wnt Proteins; Zebrafish Proteins |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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