MOUSE:PTHR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pthlh (synonyms: Pthrp)
Protein Name(s)	Parathyroid hormone-related protein PTH-rP PTHrP Parathyroid hormone-like protein PLP Osteostatin
External Links
UniProt	P22858
EMBL	M60057 M60058 M60056 BC058187
CCDS	CCDS39717.1
PIR	JN0103
UniGene	Mm.28440
ProteinModelPortal	P22858
SMR	P22858
STRING	10090.ENSMUSP00000051433
PhosphoSite	P22858
PaxDb	P22858
PRIDE	P22858
MGI	MGI:97800
eggNOG	ENOG410IW2I ENOG41126XH
HOGENOM	HOG000115765
HOVERGEN	HBG003236
InParanoid	P22858
PhylomeDB	P22858
PRO	PR:P22858
Proteomes	UP000000589
CleanEx	MM_PTHLH
GO	GO:0005737 GO:0005615 GO:0005794 GO:0005622 GO:0005654 GO:0005179 GO:0051428 GO:0007189 GO:0001958 GO:0007492 GO:0030855 GO:0048286 GO:0060649 GO:0032331 GO:0043433 GO:0060659 GO:0002076 GO:0030819 GO:0008284 GO:0016485 GO:0010468 GO:0001501 GO:0043129
InterPro	IPR003626 IPR001415
PANTHER	PTHR17223
Pfam	PF01279
SMART	SM00087
PROSITE	PS00335

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:26859332^[1]	ECO:0000314			C		Fig 1 A "The nuclear localization of C terminus PTHrP was detected using antibody against PTHrP(112–131) only in EMSCs from WT and p27-/- mice(Figure 1A)"	complete CACAO 11367
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P12272	F		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000425409 UniProtKB:P12272	F		Seeded From UniProt	complete
involved_in	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000425409 RGD:3441 UniProtKB:P12272	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000425409 RGD:3441	F		Seeded From UniProt	complete
involved_in	GO:0002076	osteoblast development	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97800 PANTHER:PTN000425409	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061182	negative regulation of chondrocyte development	PMID:9008714^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060659	nipple sheath formation	PMID:9477327^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P	results_in_formation_of:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060649	mammary gland bud elongation	PMID:9477327^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P	occurs_in:(EMAPA:17759)	Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:15162506^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	PMID:17328886^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043129	surfactant homeostasis	PMID:15162506^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:17328886^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95728	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:8895385^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:17328886^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032331	negative regulation of chondrocyte differentiation	PMID:9008714^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:15162506^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P	occurs_in:(EMAPA:16728) results_in_acquisition_of_features_of:(CL:0000082)	Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0030282	bone mineralization	PMID:11606467^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016485	protein processing	PMID:17328886^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:9008714^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:17328886^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:9921650^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3441	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3441	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002076	osteoblast development	PMID:9832460^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P	occurs_in:(EMAPA:19142) results_in_development_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001958	endochondral ossification	PMID:8895385^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:8314082^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:11606467^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2154515	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001501	skeletal system development	PMID:9008714^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P12272	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005179	P		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001415 InterPro:IPR003626	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001415 InterPro:IPR003626	C		Seeded From UniProt	complete
involved_in	GO:0055074	calcium ion homeostasis	PMID:19968565^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(EMAPA:35770) occurs_in:(EMAPA:36771)	Seeded From UniProt	complete
involved_in	GO:0055062	phosphate ion homeostasis	PMID:19968565^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(EMAPA:35770) occurs_in:(EMAPA:36771)	Seeded From UniProt	complete
involved_in	GO:0010960	magnesium ion homeostasis	PMID:19968565^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(EMAPA:35770) occurs_in:(EMAPA:36771)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11606467^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	PMID:11606467^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
enables	GO:0005179	hormone activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0372	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sun, W et al. (2016) PTHrP Nuclear Localization and Carboxyl Terminus Sequences Modulate Dental and Mandibular Development in Part via the Action of p27. Endocrinology 157 1372-84 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Amling, M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J. Cell Biol. 136 205-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Wysolmerski, JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125 1285-94 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Rubin, LP et al. (2004) Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev. Dyn. 230 278-89 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page
↑ ^7.0 ^7.1 Lee, K et al. (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137 5109-18 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Kovacs, CS et al. (2001) PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142 4983-93 PubMed GONUTS page
↑ Roelen, BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64 19-31 PubMed GONUTS page
↑ Lanske, B et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139 5194-204 PubMed GONUTS page
↑ Karaplis, AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8 277-89 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Simmonds, CS et al. (2010) Parathyroid hormone regulates fetal-placental mineral homeostasis. J. Bone Miner. Res. 25 594-605 PubMed GONUTS page

[PMID:26859332-1] Sun, W et al. (2016) PTHrP Nuclear Localization and Carboxyl Terminus Sequences Modulate Dental and Mandibular Development in Part via the Action of p27. Endocrinology 157 1372-84 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9008714-3] 3.0 ^3.1 ^3.2 ^3.3 Amling, M et al. (1997) Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J. Cell Biol. 136 205-13 PubMed GONUTS page

[PMID:9477327-4] 4.0 ^4.1 Wysolmerski, JJ et al. (1998) Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 125 1285-94 PubMed GONUTS page

[PMID:15162506-5] 5.0 ^5.1 ^5.2 Rubin, LP et al. (2004) Arrested pulmonary alveolar cytodifferentiation and defective surfactant synthesis in mice missing the gene for parathyroid hormone-related protein. Dev. Dyn. 230 278-89 PubMed GONUTS page

[PMID:17328886-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Mau, E et al. (2007) PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanisms. Dev. Biol. 305 28-39 PubMed GONUTS page

[PMID:8895385-7] 7.0 ^7.1 Lee, K et al. (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology 137 5109-18 PubMed GONUTS page

[PMID:11606467-8] 8.0 ^8.1 ^8.2 ^8.3 Kovacs, CS et al. (2001) PTH regulates fetal blood calcium and skeletal mineralization independently of PTHrP. Endocrinology 142 4983-93 PubMed GONUTS page

[PMID:9921650-9] Roelen, BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation 64 19-31 PubMed GONUTS page

[PMID:9832460-10] Lanske, B et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology 139 5194-204 PubMed GONUTS page

[PMID:8314082-11] Karaplis, AC et al. (1994) Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev. 8 277-89 PubMed GONUTS page

[PMID:19968565-12] 12.0 ^12.1 ^12.2 Simmonds, CS et al. (2010) Parathyroid hormone regulates fetal-placental mineral homeostasis. J. Bone Miner. Res. 25 594-605 PubMed GONUTS page

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MOUSE:PTHR

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