GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:PLCZ1
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Plcz1 (ECO:0000312 with MGI:MGI:2150308) | |
| Protein Name(s) | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Phosphoinositide phospholipase C-zeta-1 Phospholipase C-zeta-1 (ECO:0000250 with UniProtKB:Q86YW0) PLC-zeta-1 (ECO:0000250 with UniProtKB:Q86YW0) | |
| External Links | ||
| UniProt | Q8K4D7 | |
| EMBL | AF435950 AK006672 BC106767 | |
| CCDS | CCDS20671.1 | |
| RefSeq | NP_473407.2 XP_006506966.1 | |
| UniGene | Mm.50808 | |
| ProteinModelPortal | Q8K4D7 | |
| SMR | Q8K4D7 | |
| PhosphoSite | Q8K4D7 | |
| PRIDE | Q8K4D7 | |
| Ensembl | ENSMUST00000032356 | |
| GeneID | 114875 | |
| KEGG | mmu:114875 | |
| UCSC | uc009eny.1 | |
| CTD | 89869 | |
| MGI | MGI:2150308 | |
| eggNOG | NOG149692 | |
| GeneTree | ENSGT00760000118936 | |
| HOGENOM | HOG000006871 | |
| HOVERGEN | HBG053610 | |
| InParanoid | Q8K4D7 | |
| KO | K05861 | |
| OMA | CIVHREE | |
| OrthoDB | EOG7V49XT | |
| PhylomeDB | Q8K4D7 | |
| TreeFam | TF313216 | |
| BRENDA | 3.1.4.11 | |
| Reactome | REACT_196473 | |
| NextBio | 368899 | |
| PRO | PR:Q8K4D7 | |
| Proteomes | UP000000589 | |
| Bgee | Q8K4D7 | |
| ExpressionAtlas | Q8K4D7 | |
| Genevestigator | Q8K4D7 | |
| GO | GO:0005829 GO:0005634 GO:0048471 GO:0005509 GO:0004435 GO:0004629 GO:0004871 GO:0006816 GO:0007343 GO:0035556 GO:0016042 GO:0007275 | |
| Gene3D | 1.10.238.10 2.60.40.150 3.20.20.190 | |
| InterPro | IPR000008 IPR011992 IPR002048 IPR001192 IPR017946 IPR028395 IPR015359 IPR000909 IPR001711 | |
| PANTHER | PTHR10336 PTHR10336:SF29 | |
| Pfam | PF00168 PF09279 PF00388 PF00387 | |
| PRINTS | PR00390 | |
| SMART | SM00239 SM00148 SM00149 | |
| SUPFAM | SSF49562 SSF51695 | |
| PROSITE | PS50004 PS50222 PS50007 PS50008 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0071695 |
anatomical structure maturation |
ECO:0000314 |
P |
Figure 2 shows that PLCZ1 does not interfere with meiotic progression and that most oocytes establish mII with rPLCZ1. |
complete | |||||
| GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000314 |
F |
Figure 4 |
complete | |||||
|
involved_in |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0045120 |
pronucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2150308 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032959 |
inositol trisphosphate biosynthetic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97616 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2150308 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0262738 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0061827 |
sperm head |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1359567 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007343 |
egg activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007343 |
egg activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006816 |
calcium ion transport |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:1359567 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004629 |
phospholipase C activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5FX52 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5FX52 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0061827 |
sperm head |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060470 |
positive regulation of cytosolic calcium ion concentration involved in egg activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0032266 |
phosphatidylinositol-3-phosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0010314 |
phosphatidylinositol-5-phosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007343 |
egg activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005546 |
phosphatidylinositol-4,5-bisphosphate binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q86YW0 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004629 |
phospholipase C activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006816 |
calcium ion transport |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007343 |
egg activation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008081 |
phosphoric diester hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004435 |
phosphatidylinositol phospholipase C activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016042 |
lipid catabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007338 |
single fertilization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Yoshida, N et al. (2007) Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice. Development 134 3941-52 PubMed GONUTS page
- ↑ 2.0 2.1 Kouchi, Z et al. (2004) Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs. J. Biol. Chem. 279 10408-12 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Ito, M et al. (2008) Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish. Biol. Reprod. 78 1081-90 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Saunders, CM et al. (2002) PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development. Development 129 3533-44 PubMed GONUTS page
c
g
i
m
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0010314 ! phosphatidylinositol-5-phosphate binding
- GO:0032266 ! phosphatidylinositol-3-phosphate binding
- GO:0004435 ! phosphatidylinositol phospholipase C activity
- GO:0005546 ! phosphatidylinositol-4,5-bisphosphate binding
- GO:0004629 ! phospholipase C activity
- GO:0008081 ! phosphoric diester hydrolase activity
- GO:0060470 ! positive regulation of cytosolic calcium ion concentration involved in egg activation
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0045120 ! pronucleus
r
s
