MOUSE:PKD1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pkd1
Protein Name(s)	Polycystin-1 Autosomal dominant polycystic kidney disease 1 protein homolog
External Links
UniProt	O08852
EMBL	U70209 AC132367
CCDS	CCDS28485.1
RefSeq	NP_038658.2
UniGene	Mm.290442 Mm.30435
ProteinModelPortal	O08852
SMR	O08852
BioGrid	202204
DIP	DIP-44233N
IntAct	O08852
MINT	MINT-5163387
MEROPS	T06.001
PhosphoSite	O08852
PRIDE	O08852
Ensembl	ENSMUST00000035565
GeneID	18763
KEGG	mmu:18763
UCSC	uc008awv.1
CTD	5310
MGI	MGI:97603
eggNOG	COG3291
GeneTree	ENSGT00700000104221
HOGENOM	HOG000168445
HOVERGEN	HBG049412
InParanoid	O08852
KO	K04985
OMA	GQCNTDL
OrthoDB	EOG76X5Z6
TreeFam	TF316484
ChiTaRS	Pkd1
NextBio	294959
PRO	PR:O08852
Proteomes	UP000000589
Bgee	O08852
ExpressionAtlas	O08852
Genevestigator	O08852
GO	GO:0016323 GO:0005929 GO:0005737 GO:0070062 GO:0005794 GO:0016021 GO:0016328 GO:0031512 GO:0005634 GO:0002133 GO:0005262 GO:0030246 GO:0001568 GO:0048754 GO:0070588 GO:0006816 GO:0001502 GO:0007050 GO:0042994 GO:0050982 GO:0048565 GO:0001892 GO:0048806 GO:0007507 GO:0001701 GO:0007259 GO:0001822 GO:0001889 GO:0060428 GO:0072177 GO:0072218 GO:0072205 GO:0072287 GO:0072237 GO:0021915 GO:0007218 GO:0006807 GO:0018105 GO:0060674 GO:0031659 GO:0007204 GO:0032092 GO:0045944 GO:0006611 GO:0060236 GO:0061136 GO:0072001 GO:0034405 GO:0016337 GO:0043588 GO:0021510
Gene3D	2.60.40.670 2.60.60.20 3.10.100.10
InterPro	IPR001304 IPR016186 IPR016187 IPR000483 IPR000203 IPR001611 IPR003591 IPR008976 IPR000372 IPR000434 IPR022409 IPR002859 IPR013122 IPR000601 IPR001024 IPR006228 IPR014010 IPR002889 IPR013994
Pfam	PF01825 PF00059 PF13855 PF00801 PF08016 PF01477 PF02010 PF01822
PRINTS	PR00500
SMART	SM00034 SM00303 SM00308 SM00369 SM00082 SM00013 SM00089 SM00321
SUPFAM	SSF49299 SSF49723 SSF56436
TIGRFAMs	TIGR00864
PROSITE	PS50041 PS50221 PS51450 PS50093 PS50095 PS51111 PS51212

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005929	cilium	PMID:25405894^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:25405894^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:25405894^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	PMID:25405894^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:24939912^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:24939912^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	PMID:24939912^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:12514735^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12514735^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	PMID:20862291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042994	cytoplasmic sequestering of transcription factor	PMID:16311606^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:16311606^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16311606^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001892	embryonic placenta development	PMID:20862291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:20862291^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:20181743^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006611	protein export from nucleus	PMID:20181743^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000045	regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0198738	cell-cell signaling by wnt	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098609	cell-cell adhesion	PMID:10677526^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183523	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061136	regulation of proteasomal protein catabolic process	PMID:23001567^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060236	regulation of mitotic spindle organization	PMID:21685914^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3793793	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051290	protein heterotetramerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050982	detection of mechanical stimulus	PMID:12514735^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050982	detection of mechanical stimulus	PMID:15545994^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17373) occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	F		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036303	lymph vessel morphogenesis	PMID:24767999^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3612341	P		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034405	response to fluid shear stress	PMID:18285569^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2182840	P	occurs_in:(CL:0000115) occurs_in:(EMAPA:18601)	Seeded From UniProt	complete
part_of	GO:0031514	motile cilium	PMID:15858826^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000501)\|part_of:(EMAPA:29043) part_of:(CL:0000501)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030155	regulation of cell adhesion	PMID:24767999^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3612341	P	regulates_o_occurs_in:(CL:0002138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030010	establishment of cell polarity	PMID:24767999^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3612341	P	occurs_in:(CL:0002138)	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	F		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3333	C		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3333	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:25807483^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:11593033^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2152589	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:12007403^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3333	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	PMID:12007403^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006816	calcium ion transport	PMID:12514735^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857562	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006807	nitrogen compound metabolic process	PMID:21685914^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08795 UniProtKB:Q8VHE0	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:18285569^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000115) part_of:(EMAPA:18601)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:12514735^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373) part_of:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005929	cilium	PMID:28154160^[17]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3333	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15545994^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17373) part_of:(CL:0000134)\|part_of:(EMAPA:17373) part_of:(CL:0000066)	Seeded From UniProt	complete
contributes_to	GO:0005262	calcium channel activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P98161	F		Seeded From UniProt	complete
part_of	GO:0002133	polycystin complex	PMID:11901144^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:21685914^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O35245	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:21685914^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O35245	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001822	kidney development	PMID:21518438^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_development_of:(EMAPA:17366)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:16282979^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1197519	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:16282979^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857562	P	has_participant:(EMAPA:16039)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001568	blood vessel development	PMID:10677526^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183523	P	occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001502	cartilage condensation	PMID:11593033^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2152589	P		Seeded From UniProt	complete
part_of	GO:0016328	lateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAD3 ensembl:ENSRNOP00000015092	C		Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0198738	cell-cell signaling by wnt	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072287	metanephric distal tubule morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072237	metanephric proximal tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072218	metanephric ascending thin limb development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072205	metanephric collecting duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072177	mesonephric duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0072164	mesonephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0051290	protein heterotetramerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0048806	genitalia development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0048565	digestive tract development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F		Seeded From UniProt	complete
involved_in	GO:0043588	skin development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
enables	GO:0042813	Wnt-activated receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F		Seeded From UniProt	complete
part_of	GO:0034704	calcium channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
part_of	GO:0034703	cation channel complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
involved_in	GO:0021915	neural tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	P		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P98161 ensembl:ENSP00000262304	F		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000434	C		Seeded From UniProt	complete
enables	GO:0005262	calcium channel activity	PMID:12007403^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005929	cilium	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0969 UniProtKB-SubCell:SL-0066	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0333 UniProtKB-SubCell:SL-0132	C		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kim, H et al. (2014) Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun 5 5482 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Su, X et al. (2014) Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum. Mol. Genet. 23 5441-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Nauli, SM et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33 129-37 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Garcia-Gonzalez, MA et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS ONE 5 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Li, X et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat. Cell Biol. 7 1202-12 PubMed GONUTS page
↑ ^6.0 ^6.1 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page
↑ ^7.0 ^7.1 Kim, K et al. (2000) Polycystin 1 is required for the structural integrity of blood vessels. Proc. Natl. Acad. Sci. U.S.A. 97 1731-6 PubMed GONUTS page
↑ Foy, RL et al. (2012) Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum. Mol. Genet. 21 5456-71 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Fedeles, SV et al. (2011) A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat. Genet. 43 639-47 PubMed GONUTS page
↑ ^10.0 ^10.1 Chauvet, V et al. (2004) Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J. Clin. Invest. 114 1433-43 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Coxam, B et al. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep 7 623-33 PubMed GONUTS page
↑ ^12.0 ^12.1 Nauli, SM et al. (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117 1161-71 PubMed GONUTS page
↑ Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page
↑ Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page
↑ ^15.0 ^15.1 Boulter, C et al. (2001) Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc. Natl. Acad. Sci. U.S.A. 98 12174-9 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Bhunia, AK et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109 157-68 PubMed GONUTS page
↑ Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page
↑ Newby, LJ et al. (2002) Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 277 20763-73 PubMed GONUTS page
↑ Pandey, P et al. (2011) Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol 5 56 PubMed GONUTS page
↑ ^20.0 ^20.1 Hughes, P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ. 13 1123-7 PubMed GONUTS page

[PMID:25405894-1] 1.0 ^1.1 ^1.2 ^1.3 Kim, H et al. (2014) Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism. Nat Commun 5 5482 PubMed GONUTS page

[PMID:24939912-2] 2.0 ^2.1 ^2.2 Su, X et al. (2014) Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein. Hum. Mol. Genet. 23 5441-51 PubMed GONUTS page

[PMID:12514735-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Nauli, SM et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat. Genet. 33 129-37 PubMed GONUTS page

[PMID:20862291-4] 4.0 ^4.1 ^4.2 Garcia-Gonzalez, MA et al. (2010) Pkd1 and Pkd2 are required for normal placental development. PLoS ONE 5 PubMed GONUTS page

[PMID:16311606-5] 5.0 ^5.1 ^5.2 Li, X et al. (2005) Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat. Cell Biol. 7 1202-12 PubMed GONUTS page

[PMID:20181743-6] 6.0 ^6.1 Xia, S et al. (2010) Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts. Development 137 1075-84 PubMed GONUTS page

[PMID:10677526-7] 7.0 ^7.1 Kim, K et al. (2000) Polycystin 1 is required for the structural integrity of blood vessels. Proc. Natl. Acad. Sci. U.S.A. 97 1731-6 PubMed GONUTS page

[PMID:23001567-8] Foy, RL et al. (2012) Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum. Mol. Genet. 21 5456-71 PubMed GONUTS page

[PMID:21685914-9] 9.0 ^9.1 ^9.2 ^9.3 Fedeles, SV et al. (2011) A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation. Nat. Genet. 43 639-47 PubMed GONUTS page

[PMID:15545994-10] 10.0 ^10.1 Chauvet, V et al. (2004) Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. J. Clin. Invest. 114 1433-43 PubMed GONUTS page

[PMID:24767999-11] 11.0 ^11.1 ^11.2 Coxam, B et al. (2014) Pkd1 regulates lymphatic vascular morphogenesis during development. Cell Rep 7 623-33 PubMed GONUTS page

[PMID:18285569-12] 12.0 ^12.1 Nauli, SM et al. (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117 1161-71 PubMed GONUTS page

[PMID:15858826-13] Teilmann, SC et al. (2005) Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs. Mol. Reprod. Dev. 71 444-52 PubMed GONUTS page

[PMID:25807483-14] Li, Y et al. (2015) Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature 521 520-4 PubMed GONUTS page

[PMID:11593033-15] 15.0 ^15.1 Boulter, C et al. (2001) Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene. Proc. Natl. Acad. Sci. U.S.A. 98 12174-9 PubMed GONUTS page

[PMID:12007403-16] 16.0 ^16.1 ^16.2 Bhunia, AK et al. (2002) PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 109 157-68 PubMed GONUTS page

[PMID:28154160-17] Badgandi, HB et al. (2017) Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. J. Cell Biol. 216 743-760 PubMed GONUTS page

[PMID:11901144-18] Newby, LJ et al. (2002) Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex. J. Biol. Chem. 277 20763-73 PubMed GONUTS page

[PMID:21518438-19] Pandey, P et al. (2011) Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease. BMC Syst Biol 5 56 PubMed GONUTS page

[PMID:16282979-20] 20.0 ^20.1 Hughes, P et al. (2006) Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms. Cell Death Differ. 13 1123-7 PubMed GONUTS page

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