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PMID:18285569

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Citation

Nauli, SM, Kawanabe, Y, Kaminski, JJ, Pearce, WJ, Ingber, DE and Zhou, J (2008) Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1. Circulation 117:1161-71

Abstract

When challenged with extracellular fluid shear stress, vascular endothelial cells are known to release nitric oxide, an important vasodilator. Here, we show that the ability of cultured endothelial cells to sense a low range of fluid shear depends on apical membrane organelles, called cilia, and that cilia are compartments required for proper localization and function of the mechanosensitive polycystin-1 molecule.

Links

PubMed PMC3071982 Online version:10.1161/CIRCULATIONAHA.107.710111

Keywords

Animals; Calcium Signaling/physiology; Cells, Cultured; Cilia/metabolism; Cilia/physiology; Endothelial Cells/metabolism; Endothelial Cells/physiology; Female; Mechanotransduction, Cellular/physiology; Mice; Mice, Knockout; Mice, Mutant Strains; Nitric Oxide/biosynthesis; Polycystic Kidney, Autosomal Dominant/metabolism; Polycystic Kidney, Autosomal Dominant/pathology; Pregnancy; Shear Strength; Stress, Mechanical; TRPP Cation Channels/metabolism; TRPP Cation Channels/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PKD1

located_in

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000115)
  • part_of:(EMAPA:18601)

Seeded From UniProt

complete

MOUSE:IFT88

located_in

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000115)
  • part_of:(EMAPA:18601)

Seeded From UniProt

complete

MOUSE:IFT88

acts_upstream_of_or_within

GO:0034405: response to fluid shear stress

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2157527

P

  • occurs_in:(CL:0000115)
  • occurs_in:(EMAPA:18601)

Seeded From UniProt

complete

MOUSE:IFT88

part_of

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000115)
  • part_of:(EMAPA:18601)

Seeded From UniProt

complete

MOUSE:PKD1

part_of

GO:0005929: cilium

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000115)
  • part_of:(EMAPA:18601)

Seeded From UniProt

complete

MOUSE:PKD1

acts_upstream_of_or_within

GO:0034405: response to fluid shear stress

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2182840

P

  • occurs_in:(CL:0000115)
  • occurs_in:(EMAPA:18601)

Seeded From UniProt

complete

Notes

See also

References

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