MOUSE:PINK1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pink1
Protein Name(s)	Serine/threonine-protein kinase PINK1, mitochondrial BRPK PTEN-induced putative kinase protein 1
External Links
UniProt	Q99MQ3
EMBL	AB053476 AF316872 AL807249 BC044743 BC054349 BC067066
CCDS	CCDS18825.1
RefSeq	NP_081156.2
UniGene	Mm.18539
ProteinModelPortal	Q99MQ3
SMR	Q99MQ3
BioGrid	213129
IntAct	Q99MQ3
PhosphoSite	Q99MQ3
PaxDb	Q99MQ3
PRIDE	Q99MQ3
Ensembl	ENSMUST00000030536
GeneID	68943
KEGG	mmu:68943
UCSC	uc008vku.1
CTD	65018
MGI	MGI:1916193
eggNOG	COG0515
GeneTree	ENSGT00390000001206
HOVERGEN	HBG053601
InParanoid	Q99MQ3
KO	K05688
OMA	GPKQLAP
OrthoDB	EOG7TBC1R
PhylomeDB	Q99MQ3
TreeFam	TF313183
ChiTaRS	Pink1
NextBio	328241
PRO	PR:Q99MQ3
Proteomes	UP000000589
Bgee	Q99MQ3
CleanEx	MM_PINK1
ExpressionAtlas	Q99MQ3
Genevestigator	Q99MQ3
GO	GO:0000785 GO:0005856 GO:0005829 GO:0016021 GO:0005743 GO:0005758 GO:0005741 GO:0005739 GO:0005634 GO:0005524 GO:0010857 GO:0016301 GO:0000287 GO:0004674 GO:0071456 GO:0034599 GO:0097237 GO:0035556 GO:0000422 GO:0010629 GO:1903298 GO:0043524 GO:1902176 GO:0018105 GO:0033605 GO:0033603 GO:0043123 GO:0035307 GO:0090200 GO:0051091 GO:0032226 GO:0045727 GO:0006468 GO:0016567 GO:0010310 GO:0043523 GO:0043254 GO:0031396 GO:0022904 GO:0006950
InterPro	IPR011009 IPR000719 IPR017441 IPR008271
Pfam	PF00069
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:19229105^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:24475098^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q8CI32) occurs_in:(UBERON:0002038)	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:18560593^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022904	respiratory electron transport chain	PMID:18687901^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:18687901^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002435)	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q61221) causally_upstream_of:(GO:0051091)	Seeded From UniProt	complete
involved_in	GO:0010310	regulation of hydrogen peroxide metabolic process	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903298	negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)\|occurs_in:(CL:0000530)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035307	positive regulation of protein dephosphorylation	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q60876) part_of:(GO:0071456)	Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:24553947^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q61221)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24784582^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097237	cellular response to toxic substance	PMID:22511790^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(CHEBI:17963)	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:22511790^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	PMID:22511790^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 PANTHER:PTN001121970 RGD:1305769	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 MGI:MGI:1916193 PANTHER:PTN000540563 UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 PANTHER:PTN001121970 UniProtKB:Q9BXM7 WB:WBGene00017137 ZFIN:ZDB-GENE-041212-53	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 MGI:MGI:1916193 PANTHER:PTN001121970 RGD:1305769 UniProtKB:D6WMX4 UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 PANTHER:PTN000540563 UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029891 PANTHER:PTN001121970 UniProtKB:Q9BXM7 WB:WBGene00017137	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904881	cellular response to hydrogen sulfide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903852	positive regulation of cristae formation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903214	regulation of protein targeting to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903202	negative regulation of oxidative stress-induced cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903147	negative regulation of autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902958	positive regulation of mitochondrial electron transport, NADH to ubiquinone	PMID:24652937^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902902	negative regulation of autophagosome assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901727	positive regulation of histone deacetylase activity	PMID:25305081^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901215	negative regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900407	regulation of cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0099074	mitochondrion to lysosome transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072656	maintenance of protein location in mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072655	establishment of protein localization to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071456	cellular response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0055131	C3HC4-type RING finger domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043254	regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036289	peptidyl-serine autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033605	positive regulation of catecholamine secretion	PMID:17563363^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716083	P	regulates_o_occurs_in:(CL:0000166)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033603	positive regulation of dopamine secretion	PMID:17563363^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716083	P	regulates_o_occurs_in:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032226	positive regulation of synaptic transmission, dopaminergic	PMID:17563363^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3716083	P		Seeded From UniProt	complete
colocalizes_with	GO:0031932	TORC2 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031396	regulation of protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0031307	integral component of mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:14607334^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016242	negative regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016239	positive regulation of macroautophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
enables	GO:0010857	calcium-dependent protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010821	regulation of mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:24652937^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	C		Seeded From UniProt	complete
colocalizes_with	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	C		Seeded From UniProt	complete
colocalizes_with	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:25305081^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:O88895)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:24652937^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(MGI:MGI:1914523)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002082	regulation of oxidative phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1305769	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000422	autophagy of mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9BXM7	F		Seeded From UniProt	complete
involved_in	GO:1904925	positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:1904881	cellular response to hydrogen sulfide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:0090141	positive regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	F		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:B5DFG1 ensembl:ENSRNOP00000069316	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:2000377	regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903852	positive regulation of cristae formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903384	negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903214	regulation of protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903202	negative regulation of oxidative stress-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1903147	negative regulation of autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1902902	negative regulation of autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:1900407	regulation of cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0099074	mitochondrion to lysosome transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0097449	astrocyte projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
involved_in	GO:0090258	negative regulation of mitochondrial fission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0072656	maintenance of protein location in mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0072655	establishment of protein localization to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
enables	GO:0055131	C3HC4-type RING finger domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0043254	regulation of protein complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0036289	peptidyl-serine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0031932	TORC2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0031396	regulation of protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0031307	integral component of mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0016242	negative regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
enables	GO:0010857	calcium-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0010821	regulation of mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005742	mitochondrial outer membrane translocase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0002082	regulation of oxidative phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	C		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9BXM7 ensembl:ENSP00000364204	F		Seeded From UniProt	complete
involved_in	GO:0000422	autophagy of mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040110	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR040110	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9621286	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page
↑ Wang, X et al. (2014) BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS ONE 9 e86276 PubMed GONUTS page
↑ Wood-Kaczmar, A et al. (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3 e2455 PubMed GONUTS page
↑ ^4.0 ^4.1 Gautier, CA et al. (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 105 11364-9 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Lin, W et al. (2014) Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J. Neurosci. 34 3079-89 PubMed GONUTS page
↑ Koyano, F et al. (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510 162-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Haque, ME et al. (2012) Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J. Biol. Chem. 287 23162-70 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Nakajima, A et al. (2003) BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 201 195-201 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Morais, VA et al. (2014) PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science 344 203-7 PubMed GONUTS page
↑ ^11.0 ^11.1 Choi, HK et al. (2015) PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum. Mol. Genet. 24 1127-41 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kitada, T et al. (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 104 11441-6 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:19229105-1] Xiong, H et al. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 650-60 PubMed GONUTS page

[PMID:24475098-2] Wang, X et al. (2014) BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS ONE 9 e86276 PubMed GONUTS page

[PMID:18560593-3] Wood-Kaczmar, A et al. (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3 e2455 PubMed GONUTS page

[PMID:18687901-4] 4.0 ^4.1 Gautier, CA et al. (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. U.S.A. 105 11364-9 PubMed GONUTS page

[PMID:24553947-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Lin, W et al. (2014) Loss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxia. J. Neurosci. 34 3079-89 PubMed GONUTS page

[PMID:24784582-6] Koyano, F et al. (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature 510 162-6 PubMed GONUTS page

[PMID:22511790-7] 7.0 ^7.1 ^7.2 Haque, ME et al. (2012) Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1. J. Biol. Chem. 287 23162-70 PubMed GONUTS page

[PMID:14607334-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Nakajima, A et al. (2003) BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 201 195-201 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24652937-10] 10.0 ^10.1 ^10.2 Morais, VA et al. (2014) PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science 344 203-7 PubMed GONUTS page

[PMID:25305081-11] 11.0 ^11.1 Choi, HK et al. (2015) PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum. Mol. Genet. 24 1127-41 PubMed GONUTS page

[PMID:17563363-12] 12.0 ^12.1 ^12.2 Kitada, T et al. (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 104 11441-6 PubMed GONUTS page

[PMID:18614015-13] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

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