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PMID:14607334
| Citation |
Nakajima, A, Kataoka, K, Hong, M, Sakaguchi, M and Huh, NH (2003) BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential. Cancer Lett. 201:195-201 |
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| Abstract |
A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms. |
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| Keywords |
Amino Acid Sequence; Animals; BRCA1 Protein/chemistry; Carrier Proteins/chemistry; Cell Line; Cloning, Molecular; Colonic Neoplasms/enzymology; Colonic Neoplasms/genetics; Colonic Neoplasms/secondary; DNA, Complementary; Gene Expression Regulation, Enzymologic; Humans; Melanoma/enzymology; Melanoma/genetics; Melanoma/secondary; Mice; Molecular Sequence Data; Phosphorylation; Protein Kinases/genetics; Protein Kinases/metabolism; Sequence Homology, Amino Acid; Skin Neoplasms/enzymology; Skin Neoplasms/genetics; Skin Neoplasms/secondary; Transfection; Tumor Cells, Cultured; Ubiquitin-Protein Ligases |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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