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MOUSE:PI3R6
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Pik3r6 | |
| Protein Name(s) | Phosphoinositide 3-kinase regulatory subunit 6
Phosphoinositide 3-kinase gamma adapter protein of 87 kDa p84 PI3K adapter protein p84 PIKAP p87 PI3K adapter protein p87PIKAP | |
| External Links | ||
| UniProt | Q3U6Q4 | |
| EMBL | AY753194 DQ295832 AK151178 AK153039 AK171063 BC028998 AL606831 | |
| CCDS | CCDS24866.1 CCDS36186.1 | |
| RefSeq | NP_001004435.1 NP_001075035.1 | |
| UniGene | Mm.234573 | |
| DIP | DIP-60179N | |
| IntAct | Q3U6Q4 | |
| PhosphoSite | Q3U6Q4 | |
| PRIDE | Q3U6Q4 | |
| Ensembl | ENSMUST00000060441 ENSMUST00000102613 | |
| GeneID | 104709 | |
| KEGG | mmu:104709 | |
| UCSC | uc007jnq.1 uc007jnr.1 uc007jns.1 | |
| CTD | 146850 | |
| MGI | MGI:2144613 | |
| eggNOG | NOG28373 | |
| GeneTree | ENSGT00530000063753 | |
| HOGENOM | HOG000115540 | |
| HOVERGEN | HBG080761 | |
| InParanoid | Q3U6Q4 | |
| OMA | IQDSKFP | |
| OrthoDB | EOG7C5M7K | |
| PhylomeDB | Q3U6Q4 | |
| TreeFam | TF102035 | |
| BRENDA | 2.7.1.137 | |
| Reactome | REACT_198973 REACT_220092 REACT_223974 | |
| NextBio | 357224 | |
| PRO | PR:Q3U6Q4 | |
| Proteomes | UP000000589 | |
| Bgee | Q3U6Q4 | |
| CleanEx | MM_PIK3R6 | |
| Genevestigator | Q3U6Q4 | |
| GO | GO:0016020 GO:0005944 GO:0046935 GO:0001525 GO:0007186 GO:0046854 GO:0045766 GO:0043406 GO:0043551 | |
| InterPro | IPR019522 | |
| Pfam | PF10486 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045582 |
positive regulation of T cell differentiation |
ECO:0000315 |
P |
Figure 2. Enhanced class IA PI3K activation increases CD4+ T cell generation. |
complete | |||||
|
involved_in |
GO:0045582 |
positive regulation of T cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046935 |
1-phosphatidylinositol-3-kinase regulator activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0046934 |
phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005944 |
phosphatidylinositol 3-kinase complex, class IB |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046935 |
1-phosphatidylinositol-3-kinase regulator activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2144613 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043406 |
positive regulation of MAP kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2144613 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0014065 |
phosphatidylinositol 3-kinase signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001436768 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2144613 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005942 |
phosphatidylinositol 3-kinase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001436768 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042269 |
regulation of natural killer cell mediated cytotoxicity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0046935 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046935 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043551 |
regulation of phosphatidylinositol 3-kinase activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046935 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0046854 |
phosphatidylinositol phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0046934 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045766 |
positive regulation of angiogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5UE93 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042269 |
regulation of natural killer cell mediated cytotoxicity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q5UE93 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005944 |
phosphatidylinositol 3-kinase complex, class IB |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046935 |
1-phosphatidylinositol-3-kinase regulator activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Rodríguez-Borlado, L et al. (2003) Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. J. Immunol. 170 4475-82 PubMed GONUTS page
- ↑ 2.0 2.1 Suire, S et al. (2005) p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma. Curr. Biol. 15 566-70 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Kurig, B et al. (2009) Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma. Proc. Natl. Acad. Sci. U.S.A. 106 20312-7 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
1
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p
- GO:0046854 ! phosphatidylinositol phosphate biosynthetic process
- GO:0005942 ! phosphatidylinositol 3-kinase complex
- GO:0005944 ! phosphatidylinositol 3-kinase complex, class IB
- GO:0005886 ! plasma membrane
- GO:0043406 ! positive regulation of MAP kinase activity
- GO:0045766 ! positive regulation of angiogenesis
- GO:0045582 ! positive regulation of T cell differentiation
