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MOUSE:PF2R

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptgfr
Protein Name(s) Prostaglandin F2-alpha receptor

PGF receptor PGF2-alpha receptor Prostanoid FP receptor

External Links
UniProt P43117
EMBL D17433
AK087833
BC064794
CCDS CCDS17913.1
PIR A49877
RefSeq NP_032992.1
UniGene Mm.331442
Mm.460678
ProteinModelPortal P43117
BindingDB P43117
ChEMBL CHEMBL5000
GuidetoPHARMACOLOGY 344
PhosphoSite P43117
PRIDE P43117
Ensembl ENSMUST00000029670
ENSMUST00000106126
GeneID 19220
KEGG mmu:19220
UCSC uc008rsm.1
CTD 5737
MGI MGI:97796
eggNOG NOG263696
HOGENOM HOG000015238
HOVERGEN HBG003621
InParanoid P43117
KO K04262
OMA QGRSHHF
OrthoDB EOG7PP575
PhylomeDB P43117
TreeFam TF324982
Reactome REACT_207651
REACT_230556
NextBio 295992
PRO PR:P43117
Proteomes UP000000589
Bgee P43117
CleanEx MM_PTGFR
ExpressionAtlas P43117
Genevestigator P43117
GO GO:0005737
GO:0005576
GO:0016021
GO:0005886
GO:0004958
GO:0035584
GO:0043066
GO:0032496
InterPro IPR000276
IPR017452
IPR000141
IPR008365
IPR001244
PANTHER PTHR11866
PTHR11866:SF4
Pfam PF00001
PRINTS PR00237
PR00428
PR01788
PR00855
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032355

response to estradiol stimulus

PMID:10684792[1]

ECO:0000314

P

Positive regulation to estradiol-17β from figure 7

complete
CACAO 2195

GO:0010628

positive regulation of gene expression

PMID:21668646[2]

ECO:0000314

P

Expression of COX-2 Figure 1 B

complete
CACAO 2464

involved_in

GO:0032355

response to estradiol

PMID:10684792[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:21668646[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97795
PANTHER:PTN000933518
RGD:3435
RGD:3825

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97794
MGI:MGI:99535
PANTHER:PTN000933518
UniProtKB:P43119

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102966
MGI:MGI:98496
PANTHER:PTN000933518

P

Seeded From UniProt

complete

enables

GO:0004958

prostaglandin F receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000933533
UniProtKB:P43088

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071799

cellular response to prostaglandin D stimulus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:12606450[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179271

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035584

calcium-mediated signaling using intracellular calcium source

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032496

response to lipopolysaccharide

PMID:15834430[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2179271

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

C

Seeded From UniProt

complete

enables

GO:0004958

prostaglandin F receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:P43088

F

Seeded From UniProt

complete

involved_in

GO:0071799

cellular response to prostaglandin D stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

P

Seeded From UniProt

complete

involved_in

GO:0035584

calcium-mediated signaling using intracellular calcium source

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

C

Seeded From UniProt

complete

enables

GO:0004958

prostaglandin F receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P43088
ensembl:ENSP00000359793

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004955

prostaglandin receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001244

F

Seeded From UniProt

complete

enables

GO:0004958

prostaglandin F receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000141

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000141
InterPro:IPR000276
InterPro:IPR001244
InterPro:IPR008365

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000141
InterPro:IPR000276
InterPro:IPR001244
InterPro:IPR008365
InterPro:IPR017452

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Dong, YL & Yallampalli, C (2000) Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus. Biol. Reprod. 62 533-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Ueno, T & Fujimori, K (2011) Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade. FEBS J. 278 2901-12 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Mu, J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol. Reprod. 68 1968-74 PubMed GONUTS page
  5. ↑ Takayama, K et al. (2005) Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat. Med. 11 562-6 PubMed GONUTS page
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