GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:15834430

From GONUTS
Jump to: navigation, search
Citation

Takayama, K, Yuhki, K, Ono, K, Fujino, T, Hara, A, Yamada, T, Kuriyama, S, Karibe, H, Okada, Y, Takahata, O, Taniguchi, T, Iijima, T, Iwasaki, H, Narumiya, S and Ushikubi, F (2005) Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat. Med. 11:562-6

Abstract

Systemic inflammation induces various adaptive responses including tachycardia. Although inflammation-associated tachycardia has been thought to result from increased sympathetic discharge caused by inflammatory signals of the immune system, definitive proof has been lacking. Prostanoids, including prostaglandin (PG) D(2), PGE(2), PGF(2alpha), PGI(2) and thromboxane (TX) A(2), exert their actions through specific receptors: DP, EP (EP(1), EP(2), EP(3), EP(4)), FP, IP and TP, respectively. Here we have examined the roles of prostanoids in inflammatory tachycardia using mice that lack each of these receptors individually. The TXA(2) analog I-BOP and PGF(2alpha) each increased the beating rate of the isolated atrium of wild-type mice in vitro through interaction with TP and FP receptors, respectively. The cytokine-induced increase in beating rate was markedly inhibited in atria from mice lacking either TP or FP receptors. The tachycardia induced in wild-type mice by injection of lipopolysaccharide (LPS) was greatly attenuated in TP-deficient or FP-deficient mice and was completely absent in mice lacking both TP and FP. The beta-blocker propranolol did not block the LPS-induced increase in heart rate in wild-type animals. Our results show that inflammatory tachycardia is caused by a direct action on the heart of TXA(2) and PGF(2alpha) formed under systemic inflammatory conditions.

Links

PubMed Online version:10.1038/nm1231

Keywords

Animals; Blood Pressure; Dinoprost/metabolism; Dinoprost/pharmacology; Electrocardiography; Heart Atria/drug effects; Heart Rate/drug effects; Inflammation; Lipopolysaccharides/toxicity; Mice; Mice, Inbred C57BL; Mice, Knockout; Propranolol/pharmacology; Receptors, Prostaglandin/metabolism; Receptors, Thromboxane A2, Prostaglandin H2/metabolism; Tachycardia/chemically induced; Tachycardia/metabolism; Thromboxane A2/pharmacology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PE2R3

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137759

P

Seeded From UniProt

complete

MOUSE:TA2R

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2667333

P

Seeded From UniProt

complete

MOUSE:TA2R

acts_upstream_of_or_within

GO:0006954: inflammatory response

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2667333

P

Seeded From UniProt

complete

MOUSE:PE2R4

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137851

P

Seeded From UniProt

complete

MOUSE:PE2R1

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137762

P

Seeded From UniProt

complete

MOUSE:PI2R

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2137832

P

Seeded From UniProt

complete

MOUSE:PD2R

acts_upstream_of_or_within

GO:0006954: inflammatory response

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2386956

P

Seeded From UniProt

complete

MOUSE:PE2R2

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2651880

P

Seeded From UniProt

complete

MOUSE:PF2R

acts_upstream_of_or_within

GO:0032496: response to lipopolysaccharide

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2179271

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.