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MOUSE:PE2R2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Ptger2 (synonyms: Ptgerep2)
Protein Name(s) Prostaglandin E2 receptor EP2 subtype

PGE receptor EP2 subtype PGE2 receptor EP2 subtype Prostanoid EP2 receptor

External Links
UniProt Q62053
EMBL D50589
BC005440
CCDS CCDS26972.1
PIR S66674
RefSeq NP_032990.1
UniGene Mm.4630
ProteinModelPortal Q62053
STRING 10090.ENSMUSP00000038483
BindingDB Q62053
ChEMBL CHEMBL2488
GuidetoPHARMACOLOGY 341
PhosphoSite Q62053
PRIDE Q62053
Ensembl ENSMUST00000046891
GeneID 19217
KEGG mmu:19217
UCSC uc007tgd.2
CTD 5732
MGI MGI:97794
eggNOG NOG275624
GeneTree ENSGT00760000119188
HOGENOM HOG000115475
HOVERGEN HBG003074
InParanoid Q62053
KO K04259
OMA DPWVFAI
OrthoDB EOG72VH6G
PhylomeDB Q62053
TreeFam TF324982
Reactome REACT_230556
REACT_242871
NextBio 295980
PRO PR:Q62053
Proteomes UP000000589
Bgee Q62053
CleanEx MM_PTGER2
ExpressionAtlas Q62053
Genevestigator Q62053
GO GO:0016021
GO:0005886
GO:0004957
GO:0007189
GO:0071380
GO:0042127
GO:0032496
InterPro IPR000276
IPR017452
IPR008365
IPR001923
PANTHER PTHR11866
PTHR11866:SF8
Pfam PF00001
PRINTS PR00237
PR01788
PR00581
PROSITE PS00237
PS50262

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0032570

response to progesterone stimulus

PMID:10684792[1]

ECO:0000314

P

Positive regulation shown in figure 4

complete
CACAO 2178

involved_in

GO:0032570

response to progesterone

PMID:10684792[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071380

cellular response to prostaglandin E stimulus

PMID:18403039[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:18403039[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071380

cellular response to prostaglandin E stimulus

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97794
PANTHER:PTN000221549

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97795
PANTHER:PTN000933518
RGD:3435
RGD:3825

P

Seeded From UniProt

complete

involved_in

GO:0007189

adenylate cyclase-activating G protein-coupled receptor signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:97794
MGI:MGI:99535
PANTHER:PTN000933518
UniProtKB:P43119

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:102966
MGI:MGI:98496
PANTHER:PTN000933518

P

Seeded From UniProt

complete

enables

GO:0004957

prostaglandin E receptor activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000221549
RGD:620020

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904346

positive regulation of gastric mucosal blood circulation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620020

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042127

regulation of cell population proliferation

PMID:11533709[4]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88039

P

occurs_in:(EMAPA:32874)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032496

response to lipopolysaccharide

PMID:15834430[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2651880

P

Seeded From UniProt

complete

enables

GO:0004957

prostaglandin E receptor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:620020

F

Seeded From UniProt

complete

involved_in

GO:1904346

positive regulation of gastric mucosal blood circulation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62928
ensembl:ENSRNOP00000064907

P

Seeded From UniProt

complete

enables

GO:0004957

prostaglandin E receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q62928
ensembl:ENSRNOP00000064907

F

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276

F

Seeded From UniProt

complete

enables

GO:0004957

prostaglandin E receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001923

F

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001923
InterPro:IPR008365

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000276
InterPro:IPR001923
InterPro:IPR008365
InterPro:IPR017452

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0807

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0004930

G protein-coupled receptor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0297

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Dong, YL & Yallampalli, C (2000) Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus. Biol. Reprod. 62 533-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 Sakihama, T et al. (2008) Functional reconstitution of G-protein-coupled receptor-mediated adenylyl cyclase activation by a baculoviral co-display system. J. Biotechnol. 135 28-33 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ Sonoshita, M et al. (2001) Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Nat. Med. 7 1048-51 PubMed GONUTS page
  5. ↑ Takayama, K et al. (2005) Thromboxane A2 and prostaglandin F2alpha mediate inflammatory tachycardia. Nat. Med. 11 562-6 PubMed GONUTS page
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