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MOUSE:PAR6B

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Pard6b (synonyms: Par6b)
Protein Name(s) Partitioning defective 6 homolog beta

PAR-6 beta PAR-6B

External Links
UniProt Q9JK83
EMBL AF252291
AL831766
CH466551
BC025147
CCDS CCDS17108.1
RefSeq NP_067384.2
UniGene Mm.292834
PDB 1NF3
PDBsum 1NF3
ProteinModelPortal Q9JK83
SMR Q9JK83
IntAct Q9JK83
MINT MINT-4106590
PhosphoSite Q9JK83
MaxQB Q9JK83
PaxDb Q9JK83
PRIDE Q9JK83
Ensembl ENSMUST00000052125
GeneID 58220
KEGG mmu:58220
UCSC uc008oao.2
CTD 84612
MGI MGI:2135605
eggNOG NOG315424
GeneTree ENSGT00390000005255
HOGENOM HOG000231716
HOVERGEN HBG053509
InParanoid Q9JK83
KO K06093
OMA EPQQIPK
OrthoDB EOG73JKWB
TreeFam TF312899
Reactome REACT_236746
EvolutionaryTrace Q9JK83
NextBio 314229
PRO PR:Q9JK83
Proteomes UP000000589
Bgee Q9JK83
Genevestigator Q9JK83
GO GO:0045177
GO:0005938
GO:0070062
GO:0005634
GO:0005886
GO:0043234
GO:0005923
GO:0007049
GO:0051301
GO:0006461
Gene3D 2.30.42.10
InterPro IPR000270
IPR001478
Pfam PF00564
PF00595
SMART SM00666
SM00228
SUPFAM SSF50156
PROSITE PS50106

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0001831

trophectodermal cellular morphogenesis

PMID:20505164[1]

ECO:0000314

P

Figure 1 displays how Pard6b knockdown suppresses formation of the blastocyte cavity, although it does not affect early blastomere cleavages in embryo (Table 1).

complete
CACAO 3977

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BYG5

P

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BYG5

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9BYG5

C

Seeded From UniProt

complete

involved_in

GO:0060341

regulation of cellular localization

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001019968
RGD:1303273

P

Seeded From UniProt

complete

enables

GO:0017048

Rho GTPase binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1927223
PANTHER:PTN001019968
WB:WBGene00003921

F

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0026192
MGI:MGI:2135605
PANTHER:PTN001019968
ZFIN:ZDB-GENE-010319-35
ZFIN:ZDB-GENE-090312-133

C

Seeded From UniProt

complete

involved_in

GO:0007163

establishment or maintenance of cell polarity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001019968
WB:WBGene00003921

P

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001019969
UniProtKB:Q9NPB6

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1927223
MGI:MGI:2135605
PANTHER:PTN001019968
WB:WBGene00003921

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1927223
MGI:MGI:2135605
PANTHER:PTN001019968

C

Seeded From UniProt

complete

enables

GO:0005080

protein kinase C binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001019968
WB:WBGene00003921

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0065003

protein-containing complex assembly

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG5

P

Seeded From UniProt

complete

part_of

GO:0045177

apical part of cell

PMID:15950600[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16046)
  • part_of:(CL:1000274)|part_of:(EMAPA:16040)
  • part_of:(CL:0000007)|part_of:(EMAPA:16040)
  • part_of:(CL:0000007)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:1308205

C

Seeded From UniProt

complete

part_of

GO:0016324

apical plasma membrane

PMID:22333836[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:31865)

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:15950600[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16041)
  • part_of:(CL:0000007)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

PMID:15950600[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16046)
  • part_of:(CL:1000274)|part_of:(EMAPA:16040)
  • part_of:(CL:0000007)|part_of:(EMAPA:16041)
  • part_of:(CL:0000007)

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG5

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG5

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9BYG5

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:22333836[4]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:31865)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15950600[3]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16036)
  • part_of:(CL:0000007)|part_of:(EMAPA:16037)
  • part_of:(CL:0000007)

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D4A2F2
ensembl:ENSRNOP00000014568

C

Seeded From UniProt

complete

involved_in

GO:0065003

protein-containing complex assembly

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG5
ensembl:ENSP00000360672

P

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG5
ensembl:ENSP00000360672

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG5
ensembl:ENSP00000360672

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9BYG5
ensembl:ENSP00000360672

C

Seeded From UniProt

complete

involved_in

GO:0007043

cell-cell junction assembly

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034873

P

Seeded From UniProt

complete

involved_in

GO:0007163

establishment or maintenance of cell polarity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034873

P

Seeded From UniProt

complete

part_of

GO:0030054

cell junction

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0965

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

part_of

GO:0005923

bicellular tight junction

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0796
UniProtKB-SubCell:SL-0265

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Alarcon, VB (2010) Cell polarity regulator PARD6B is essential for trophectoderm formation in the preimplantation mouse embryo. Biol. Reprod. 83 347-58 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Vinot, S et al. (2005) Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction. Dev. Biol. 282 307-19 PubMed GONUTS page
  4. ↑ 4.0 4.1 Tao, H et al. (2012) Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev. Biol. 364 138-48 PubMed GONUTS page
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