MOUSE:OTU7B

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Otud7b
Protein Name(s)	OTU domain-containing protein 7B Cellular zinc finger anti-NF-kappa-B protein Zinc finger A20 domain-containing protein 1 Zinc finger protein Cezanne
External Links
UniProt	B2RUR8
EMBL	AC092094 CH466620 BC141397 BC037040 BC141398
CCDS	CCDS17629.1
RefSeq	NP_001020784.1 NP_001020785.1 XP_006501447.1 XP_006501448.1 XP_006501449.1 XP_006501450.1 XP_006501451.1 XP_006501452.1
UniGene	Mm.272336 Mm.487453
ProteinModelPortal	B2RUR8
SMR	B2RUR8
DIP	DIP-60128N
IntAct	B2RUR8
STRING	10090.ENSMUSP00000088291
MEROPS	C64.002
MaxQB	B2RUR8
PaxDb	B2RUR8
PRIDE	B2RUR8
Ensembl	ENSMUST00000035519 ENSMUST00000090785 ENSMUST00000098849
GeneID	229603
KEGG	mmu:229603
UCSC	uc008qma.1
CTD	56957
MGI	MGI:2654703
eggNOG	NOG282016
GeneTree	ENSGT00530000062989
HOGENOM	HOG000048103
HOVERGEN	HBG050904
InParanoid	B2RUR8
KO	K11860
OMA	YATFPRQ
OrthoDB	EOG7JHM57
PhylomeDB	B2RUR8
TreeFam	TF323312
ChiTaRS	Otud7b
NextBio	379553
PRO	PR:B2RUR8
Proteomes	UP000000589
ExpressionAtlas	B2RUR8
Genevestigator	B2RUR8
GO	GO:0005737 GO:0005634 GO:0008234 GO:0003677 GO:0070530 GO:1990380 GO:0004221 GO:0004843 GO:0008270 GO:0002385 GO:0043124 GO:0032717 GO:1900181 GO:0000122 GO:0016579 GO:0035871 GO:0071108 GO:0070536
InterPro	IPR003323 IPR002653
Pfam	PF02338
PROSITE	PS50802 PS51036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21097510^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P13597)	Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:18281465^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	PMID:23334419^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:23334419^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	PMID:23334419^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6GQQ9	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	PMID:23334419^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002385	mucosal immune response	PMID:23334419^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:Q9UGI0	P		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN000332227 UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332227 UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001092 UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000332227 UniProtKB:Q6GQQ9 UniProtKB:Q8TE49	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196377 MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q9UGI0	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2654703 PANTHER:PTN001001090 UniProtKB:P21580 UniProtKB:Q6GQQ9 UniProtKB:Q8TE49 UniProtKB:Q9UGI0	F		Seeded From UniProt	complete
enables	GO:1990380	Lys48-specific deubiquitinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900181	negative regulation of protein localization to nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032717	negative regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016579	protein deubiquitination	PMID:12682062^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12682062^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:12682062^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q6GQQ9	P		Seeded From UniProt	complete
enables	GO:1990380	Lys48-specific deubiquitinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	F		Seeded From UniProt	complete
involved_in	GO:1900181	negative regulation of protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
involved_in	GO:0071108	protein K48-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
involved_in	GO:0070536	protein K63-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
involved_in	GO:0035871	protein K11-linked deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
involved_in	GO:0032717	negative regulation of interleukin-8 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6GQQ9 ensembl:ENSP00000462729	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002653	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page
↑ Tran, H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22 528-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hu, H et al. (2013) OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature 494 371-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Evans, PC et al. (2003) A novel type of deubiquitinating enzyme. J. Biol. Chem. 278 23180-6 PubMed GONUTS page

[PMID:21097510-1] McNally, RS et al. (2011) DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB. J. Biol. Chem. 286 4098-106 PubMed GONUTS page

[PMID:18281465-2] Tran, H et al. (2008) Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes Dev. 22 528-42 PubMed GONUTS page

[PMID:23334419-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hu, H et al. (2013) OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature 494 371-4 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12682062-5] 5.0 ^5.1 ^5.2 Evans, PC et al. (2003) A novel type of deubiquitinating enzyme. J. Biol. Chem. 278 23180-6 PubMed GONUTS page

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MOUSE:OTU7B

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