MOUSE:OPA1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Opa1
Protein Name(s)	Dynamin-like 120 kDa protein, mitochondrial Large GTP-binding protein LargeG Optic atrophy protein 1 homolog Dynamin-like 120 kDa protein, form S1
External Links
UniProt	P58281
EMBL	AB044138 AK029157 AK038446 AK044657 AK050383 AK145620 BC025160 BC138665 BC145959
CCDS	CCDS28096.1
RefSeq	NP_598513.1 XP_006522720.1
UniGene	Mm.274285
ProteinModelPortal	P58281
SMR	P58281
BioGrid	216522
IntAct	P58281
MINT	MINT-4105859
STRING	10090.ENSMUSP00000036993
iPTMnet	P58281
PhosphoSitePlus	P58281
MaxQB	P58281
PaxDb	P58281
PeptideAtlas	P58281
PRIDE	P58281
Ensembl	ENSMUST00000160597 ENSMUST00000161186
GeneID	74143
KEGG	mmu:74143
UCSC	uc007ywf.2
CTD	4976
MGI	MGI:1921393
eggNOG	KOG0447 COG0699
GeneTree	ENSGT00550000074851
HOVERGEN	HBG019108
InParanoid	P58281
KO	K17079
OMA	MTVKGPG
OrthoDB	EOG091G01NV
PhylomeDB	P58281
TreeFam	TF314250
BRENDA	3.6.5.5
Reactome	[www.reactome.org/content/detail/R-MMU-169911 R-MMU-169911]
ChiTaRS	Opa1
PRO	PR:P58281
Proteomes	UP000000589
Bgee	ENSMUSG00000038084
CleanEx	MM_OPA1
ExpressionAtlas	P58281
Genevisible	P58281
GO	GO:0005829 GO:0030425 GO:0016021 GO:0016020 GO:0030061 GO:0005743 GO:0005758 GO:0005741 GO:0005739 GO:0005654 GO:0005525 GO:0003924 GO:0008017 GO:0006915 GO:0090398 GO:0003374 GO:0007007 GO:0000266 GO:0008053 GO:0000002 GO:0007005 GO:1902236 GO:2001243 GO:0090201 GO:0001843 GO:0007601
Gene3D	3.40.50.300
InterPro	IPR001401 IPR022812 IPR030381 IPR033047 IPR027417
PANTHER	PTHR11566 PTHR11566:SF100
Pfam	PF00350
PRINTS	PR00195
SMART	SM00053
SUPFAM	SSF52540
PROSITE	PS51718

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008053	mitochondrial fusion	PMID:15899901^[1]	ECO:0000315			P		OPA-1 shows positive regulation of mitochondrial fusion, as seen and inferred from Table 1 and Figure 2C. Uniprot Nomenclature: Dynamin-like 120 kDa protein, mitochondrial (OPA1_MOUSE) Uniprot ID: P58281 Organism: Mus musculus (Mouse)	complete CACAO 12466
	GO:0030307	positive regulation of cell growth	PMID:15899901^[1]	ECO:0000315			P		OPA1 is needed for cell growth, as OPA1-RNAi cells grew much more slowly and attained only 15% of the density of mock-infected control cells, as seen in Figure 3C. Uniprot Nomenclature: Dynamin-like 120 kDa protein, mitochondrial (OPA1_MOUSE) Uniprot ID: P58281 Organism: Mus musculus (Mouse)	complete CACAO 12469
	GO:0070584	mitochondrion morphogenesis	PMID:15899901^[1]	ECO:0000315			P		OPA1-RNAi cells showed a lack of mitochondrial morphologies. OPA1 is thus needed for any mitochondrial morphology, as seen in FIG. 1. Dynamin-like 120 kDa protein, mitochondrial Mouse	complete CACAO 12715
	GO:0008053	mitochondrial fusion	PMID:15899901^[1]	ECO:0000315			P		OPA1-RNAi cells had 0% mitochondrial fusion as seen in TABLE 1. Moreover, these results (TABLE 1 and FIGURE 2) demonstrate that OPA1 is strictly required for mitochondrial fusion. Dynamin-like 120 kDa protein, mitochondrial Mouse	complete CACAO 12716
	GO:0016049	cell growth	PMID:15899901^[1]	ECO:0000315			P		As seen in Figure 3, growth defects were seen in OPA1-RNAi cells. Indicating that OPA1 is needed for proper cell growth. Dynamin-like 120 kDa protein, mitochondrial Mouse	complete CACAO 12717
	GO:0009060	aerobic respiration	PMID:15899901^[1]	ECO:0000315			P		Severe aerobic respiratory defects are observable in OPA1-RNAi cells. These were reversible when restoration of OPA1 was done, as seen in FIG 5, F and G. Dynamin-like 120 kDa protein, mitochondrial Mouse	complete CACAO 12718
enables	GO:1901612	cardiolipin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
enables	GO:0070300	phosphatidic acid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
involved_in	GO:0097749	membrane tubulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:0046039	GTP metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:0000002	mitochondrial genome maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:23453807^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:28746876^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:16839884^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:Q5XJY4)	Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	PMID:16839884^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:Q5XJY4)\|happens_during(GO:2001243)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:11847212^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030061	mitochondrial crista	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:0007007	inner mitochondrial membrane organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	PMID:11847212^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	PMID:11847212^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:16839884^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
involved_in	GO:0061025	membrane fusion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 RGD:620416	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 TAIR:locus:2006777 TAIR:locus:2012763 UniProtKB:Q8S944	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 PANTHER:PTN000170013	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261276 MGI:MGI:1921393 PANTHER:PTN002480282 RGD:708423 UniProtKB:O60313 WB:WBGene00001134	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003392 MGI:MGI:1921256 PANTHER:PTN000170013 PomBase:SPBC12C2.08 RGD:2513 RGD:628821 RGD:71096 RGD:727949 TAIR:locus:2006777 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:P20591 UniProtKB:P27594 UniProtKB:P79135 UniProtKB:Q8IHR4 dictyBase:DDB_G0277849 dictyBase:DDB_G0277851	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170013 RGD:2513 RGD:727949 SGD:S000001709 SGD:S000003924 UniProtKB:K7GKN2 UniProtKB:O00429 UniProtKB:O60313 UniProtKB:P27594 UniProtKB:P42697 UniProtKB:Q8S944 WB:WBGene00001130 dictyBase:DDB_G0277849	F		Seeded From UniProt	complete
involved_in	GO:0003374	dynamin family protein polymerization involved in mitochondrial fission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000170085 UniProtKB:O00429	P		Seeded From UniProt	complete
involved_in	GO:0000266	mitochondrial fission	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0026479 MGI:MGI:1921256 PANTHER:PTN000902162 SGD:S000003924 TAIR:locus:2006777 UniProtKB:O00429 UniProtKB:Q8LFT2 UniProtKB:Q8S944 WB:WBGene00001093	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
enables	GO:1901612	cardiolipin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900078	positive regulation of cellular response to insulin stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900006	positive regulation of dendrite development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097749	membrane tubulation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090398	cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070584	mitochondrion morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
enables	GO:0070300	phosphatidic acid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061003	positive regulation of dendritic spine morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051259	protein complex oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048312	intracellular distribution of mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046628	positive regulation of insulin receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046039	GTP metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036444	calcium import into the mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
part_of	GO:0031314	extrinsic component of mitochondrial inner membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	C		Seeded From UniProt	complete
part_of	GO:0030061	mitochondrial crista	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
enables	GO:0019900	kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014042	positive regulation of neuron maturation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010636	positive regulation of mitochondrial fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008053	mitochondrial fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007601	visual perception	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007007	inner mitochondrial membrane organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	C		Seeded From UniProt	complete
part_of	GO:0005758	mitochondrial intermembrane space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	PMID:12865426^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17035996^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11847212^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
colocalizes_with	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:708423	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001843	neural tube closure	PMID:15755804^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3578528	P	has_participant:(EMAPA:16530)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000002	mitochondrial genome maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60313	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001401 InterPro:IPR033047	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001401 InterPro:IPR030381	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033047	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033047	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008053	mitochondrial fusion	PMID:20038678^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007005	mitochondrion organization	PMID:20038678^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:11847212^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005743	mitochondrial inner membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0999 UniProtKB-SubCell:SL-0168	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007601	visual perception	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0844	P		Seeded From UniProt	complete
involved_in	GO:0050896	response to stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0716	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chen, H et al. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280 26185-92 PubMed GONUTS page
↑ Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page
↑ Huang, G et al. (2017) WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion. Cell Rep 20 923-934 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cipolat, S et al. (2006) Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126 163-75 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Misaka, T et al. (2002) Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology. J. Biol. Chem. 277 15834-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Karbowski, M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 658-62 PubMed GONUTS page
↑ García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page
↑ ^12.0 ^12.1 Ehses, S et al. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187 1023-36 PubMed GONUTS page

[PMID:15899901-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chen, H et al. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280 26185-92 PubMed GONUTS page

[PMID:23453807-2] Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page

[PMID:28746876-3] Huang, G et al. (2017) WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion. Cell Rep 20 923-934 PubMed GONUTS page

[PMID:16839884-4] 4.0 ^4.1 ^4.2 Cipolat, S et al. (2006) Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell 126 163-75 PubMed GONUTS page

[PMID:11847212-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Misaka, T et al. (2002) Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology. J. Biol. Chem. 277 15834-42 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12865426-7] Da Cruz, S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J. Biol. Chem. 278 41566-71 PubMed GONUTS page

[PMID:18614015-8] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-9] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:17035996-10] Karbowski, M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 658-62 PubMed GONUTS page

[PMID:15755804-11] García-García, MJ et al. (2005) Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc. Natl. Acad. Sci. U.S.A. 102 5913-9 PubMed GONUTS page

[PMID:20038678-12] 12.0 ^12.1 Ehses, S et al. (2009) Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1. J. Cell Biol. 187 1023-36 PubMed GONUTS page

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