MOUSE:NR2C2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nr2c2 (synonyms: Mtr2r1, Tak1, Tr4)
Protein Name(s)	Nuclear receptor subfamily 2 group C member 2 Orphan nuclear receptor TAK1 Orphan nuclear receptor TR4 Testicular receptor 4
External Links
UniProt	P49117
EMBL	U11688 S75970 U32939
CCDS	CCDS20372.1
PIR	I54075 JC4299
RefSeq	NP_035760.1 XP_006505967.1 XP_006505968.1 XP_006505969.1
UniGene	Mm.442385 Mm.87062
ProteinModelPortal	P49117
SMR	P49117
IntAct	P49117
MINT	MINT-6797261
PhosphoSite	P49117
MaxQB	P49117
PaxDb	P49117
PRIDE	P49117
Ensembl	ENSMUST00000113460
GeneID	22026
KEGG	mmu:22026
UCSC	uc009cyp.2
CTD	7182
MGI	MGI:1352466
eggNOG	NOG297520
HOGENOM	HOG000013058
HOVERGEN	HBG008596
InParanoid	P49117
KO	K08544
OrthoDB	EOG7FJH0K
PhylomeDB	P49117
TreeFam	TF316650
Reactome	REACT_234105
NextBio	301768
PRO	PR:P49117
Proteomes	UP000000589
Bgee	P49117
CleanEx	MM_NR2C2
ExpressionAtlas	P49117
Genevestigator	P49117
GO	GO:0005634 GO:0043565 GO:0003700 GO:0003707 GO:0008270 GO:0030154 GO:0021549 GO:0051321 GO:0048520 GO:0040019 GO:0007283 GO:0006351
Gene3D	1.10.565.10 3.30.50.10
InterPro	IPR008946 IPR000536 IPR001723 IPR001628 IPR013088
Pfam	PF00104 PF00105
PRINTS	PR00398 PR00047
SMART	SM00430 SM00399
SUPFAM	SSF48508
PROSITE	PS00031 PS51030

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045663	positive regulation of myoblast differentiation	PMID:22337877^[1]	ECO:0000314			P		Fig. 2	complete CACAO 3801
	GO:0038066	p38MAPK cascade	PMID:22337877^[1]	ECO:0000270			P		Fig. 4	complete CACAO 3812
involved_in	GO:0038066	p38MAPK cascade	PMID:22337877^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045663	positive regulation of myoblast differentiation	PMID:22337877^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048520	positive regulation of behavior	PMID:20393820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040019	positive regulation of embryonic development	PMID:19131575^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	PMID:20393820^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051321	meiotic cell cycle	PMID:15199144^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050563	P	occurs_in:(CL:0000017)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:15199144^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3050563	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P49116	F		Seeded From UniProt	complete
involved_in	GO:0043401	steroid hormone mediated signaling pathway	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003707	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
enables	GO:0003707	steroid hormone receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001723	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR001723 InterPro:IPR013088	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628 InterPro:IPR013088	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001628	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:9851930^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0744	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Tran, P et al. (2012) TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J. Biol. Chem. 287 11602-15 PubMed GONUTS page
↑ ^2.0 ^2.1 Kim, YS et al. (2010) Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum 9 310-23 PubMed GONUTS page
↑ Shyr, CR et al. (2009) Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology 150 2454-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Mu, X et al. (2004) Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol. Cell. Biol. 24 5887-99 PubMed GONUTS page
↑ Poltorak, A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 2085-8 PubMed GONUTS page

[PMID:22337877-1] 1.0 ^1.1 ^1.2 ^1.3 Tran, P et al. (2012) TGF-β-activated kinase 1 (TAK1) and apoptosis signal-regulating kinase 1 (ASK1) interact with the promyogenic receptor Cdo to promote myogenic differentiation via activation of p38MAPK pathway. J. Biol. Chem. 287 11602-15 PubMed GONUTS page

[PMID:20393820-2] 2.0 ^2.1 Kim, YS et al. (2010) Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum 9 310-23 PubMed GONUTS page

[PMID:19131575-3] Shyr, CR et al. (2009) Roles of testicular orphan nuclear receptors 2 and 4 in early embryonic development and embryonic stem cells. Endocrinology 150 2454-62 PubMed GONUTS page

[PMID:15199144-4] 4.0 ^4.1 Mu, X et al. (2004) Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol. Cell. Biol. 24 5887-99 PubMed GONUTS page

[PMID:9851930-5] Poltorak, A et al. (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 2085-8 PubMed GONUTS page

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MOUSE:NR2C2

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