MOUSE:NOD2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nod2 (synonyms: Card15)
Protein Name(s)	Nucleotide-binding oligomerization domain-containing protein 2 Caspase recruitment domain-containing protein 15
External Links
UniProt	Q8K3Z0
EMBL	AF520774 BC044774
UniGene	Mm.222633
ProteinModelPortal	Q8K3Z0
SMR	Q8K3Z0
DIP	DIP-46115N
PhosphoSite	Q8K3Z0
PRIDE	Q8K3Z0
Ensembl	ENSMUST00000054324 ENSMUST00000109634
UCSC	uc009mrq.1
MGI	MGI:2429397
eggNOG	NOG248107
GeneTree	ENSGT00710000106284
HOGENOM	HOG000113814
HOVERGEN	HBG050792
InParanoid	Q8K3Z0
OMA	NVGHLKL
PhylomeDB	Q8K3Z0
TreeFam	TF352118
Reactome	REACT_204812 REACT_211125 REACT_219800 REACT_224208 REACT_237946
PRO	PR:Q8K3Z0
Proteomes	UP000000589
Bgee	Q8K3Z0
ExpressionAtlas	Q8K3Z0
Genevestigator	Q8K3Z0
GO	GO:0009986 GO:0008180 GO:0005737 GO:0005856 GO:0005829 GO:0005886 GO:0043234 GO:0031982 GO:0005524 GO:0050700 GO:0016888 GO:0019899 GO:0032500 GO:0042834 GO:0019901 GO:0002253 GO:0035419 GO:0071225 GO:0071407 GO:0071224 GO:0002367 GO:0006952 GO:0042742 GO:0050830 GO:0016045 GO:0009595 GO:0032498 GO:0002381 GO:0006954 GO:0045087 GO:0002227 GO:0035556 GO:0071608 GO:0030277 GO:0044130 GO:0002862 GO:0032689 GO:0032695 GO:0032701 GO:0032703 GO:2000110 GO:0032088 GO:0002710 GO:0034136 GO:0032720 GO:0070431 GO:0006963 GO:0050871 GO:0006965 GO:0002606 GO:0002732 GO:0050679 GO:0070374 GO:0002925 GO:0043123 GO:0045089 GO:0050718 GO:0032733 GO:0032735 GO:0032740 GO:0032755 GO:0046330 GO:0043410 GO:0051092 GO:0051770 GO:0045747 GO:0051353 GO:0050731 GO:0050766 GO:0043552 GO:2000363 GO:0060585 GO:0031398 GO:0032874 GO:0045944 GO:0032760 GO:0002830 GO:0051259 GO:0050727 GO:0090022 GO:0043330 GO:0032496 GO:0032495 GO:0007584 GO:0032494 GO:0007165
Gene3D	1.10.533.10
InterPro	IPR001315 IPR011029 IPR018228 IPR007111 IPR027417
Pfam	PF00619
SUPFAM	SSF47986 SSF52540
PROSITE	PS50209 PS50837

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0002227	innate immune response in mucosa	PMID:23526993^[1]	ECO:0000314			P		Figures 7B,D,F: Upregulation of Nod2 occurred on day 7 after the lethal Ehrlichia infection, IOE.	complete CACAO 9438
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0045089	positive regulation of innate immune response	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0045089)	Seeded From UniProt	complete
involved_in	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	PMID:16203728^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000042) part_of:(GO:0032495)	Seeded From UniProt	complete
involved_in	GO:2000363	positive regulation of prostaglandin-E synthase activity	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000110	negative regulation of macrophage apoptotic process	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	PMID:21156799^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051353	positive regulation of oxidoreductase activity	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:18855982^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	PMID:21156799^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	PMID:21156799^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	PMID:21156799^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002830	positive regulation of type 2 immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	PMID:20008287^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
involved_in	GO:0032498	detection of muramyl dipeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
involved_in	GO:0016045	detection of bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
involved_in	GO:0071225	cellular response to muramyl dipeptide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:15620648^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
involved_in	GO:0002367	cytokine production involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2429397 PANTHER:PTN000648064 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648064 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 UniProtKB:Q9HC29 UniProtKB:Q9Y239	P		Seeded From UniProt	complete
involved_in	GO:0032495	response to muramyl dipeptide	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2429397 PANTHER:PTN000648064 RGD:1306368 UniProtKB:Q6E804 UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000648064 UniProtKB:Q9HC29	C		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[7]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 RGD:1306368 UniProtKB:Q7RTR2 UniProtKB:Q86WI3 UniProtKB:Q9HC29 UniProtKB:Q9Y239 ZFIN:ZDB-GENE-061108-4	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032689	negative regulation of interferon-gamma production	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032689	negative regulation of interferon-gamma production	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	PMID:18167348^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
enables	GO:0032500	muramyl dipeptide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306368	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032498	detection of muramyl dipeptide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:14560001^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:14560001^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	PMID:15220916^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032495	response to muramyl dipeptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306368	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032494	response to peptidoglycan	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032494	response to peptidoglycan	PMID:15220916^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
enables	GO:0030544	Hsp70 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030277	maintenance of gastrointestinal epithelium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016045	detection of bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306368	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:32764)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	PMID:18167348^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306368	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	PMID:16949315^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	regulates_o_has_participant:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002830	positive regulation of type 2 immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002732	positive regulation of dendritic cell cytokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1306368	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002710	negative regulation of T cell mediated immunity	PMID:16949315^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	regulates_o_has_participant:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002381	immunoglobulin production involved in immunoglobulin mediated immune response	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002374	cytokine secretion involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002367	cytokine production involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002253	activation of immune response	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002227	innate immune response in mucosa	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	has_participant:(EMAPA:32764)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904417	positive regulation of xenophagy	PMID:22033934^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)\|occurs_in:(CL:0000451) regulates_o_occurs_in:(CL:0000451)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902523	positive regulation of protein K63-linked ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:22033934^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(CL:0000235) occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090022	regulation of neutrophil chemotaxis	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:16332) regulates_o_results_in_movement_of:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071608	macrophage inflammatory protein-1 alpha production	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071225	cellular response to muramyl dipeptide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071224	cellular response to peptidoglycan	PMID:16949315^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:23892723^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:22033934^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050871	positive regulation of B cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:18261938^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341839	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:18261938^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050830	defense response to Gram-positive bacterium	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050766	positive regulation of phagocytosis	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(CL:0000775)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:19218085^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0050700	CARD domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:17187069^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045089	positive regulation of innate immune response	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_has_participant:(EMAPA:32764)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043330	response to exogenous dsRNA	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:17187069^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:18261938^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341839	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:18261938^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:17187069^[18]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341839	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:15692051^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:14560001^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:15220916^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HC29	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032720	negative regulation of tumor necrosis factor production	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032703	negative regulation of interleukin-2 production	PMID:19139201^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3529594	P	regulates_o_occurs_in:(EMAPA:35770)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032701	negative regulation of interleukin-18 production	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032695	negative regulation of interleukin-12 production	PMID:16949315^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032695	negative regulation of interleukin-12 production	PMID:15220916^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2680581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032695	negative regulation of interleukin-12 production	PMID:15220916^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016888	P		Seeded From UniProt	complete
enables	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018228	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009595	detection of biotic stimulus	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006952	defense response	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15967716^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-741383	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0026	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chattoraj, P et al. (2013) TLR2 and Nod2 mediate resistance or susceptibility to fatal intracellular Ehrlichia infection in murine models of ehrlichiosis. PLoS ONE 8 e58514 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Bansal, K & Balaji, KN (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J. Biol. Chem. 286 5823-35 PubMed GONUTS page
↑ McDonald, C et al. (2005) A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J. Biol. Chem. 280 40301-9 PubMed GONUTS page
↑ Cruickshank, SM et al. (2008) Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival. World J. Gastroenterol. 14 5834-41 PubMed GONUTS page
↑ Asano, J et al. (2010) Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J. Immunol. 184 736-45 PubMed GONUTS page
↑ Abbott, DW et al. (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14 2217-27 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page
↑ ^10.0 ^10.1 Röhrl, J et al. (2008) Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J. Biol. Chem. 283 5414-9 PubMed GONUTS page
↑ ^11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Pauleau, AL & Murray, PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol. Cell. Biol. 23 7531-9 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Watanabe, T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25 473-85 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Anand, PK et al. (2011) TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J. Biol. Chem. 286 42981-91 PubMed GONUTS page
↑ Yang, S et al. (2013) Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat. Immunol. 14 927-36 PubMed GONUTS page
↑ ^16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page
↑ Saha, S et al. (2009) PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe 5 137-50 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Hsu, YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 198-205 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 Martinon, F & Tschopp, J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26 447-54 PubMed GONUTS page

[PMID:23526993-1] Chattoraj, P et al. (2013) TLR2 and Nod2 mediate resistance or susceptibility to fatal intracellular Ehrlichia infection in murine models of ehrlichiosis. PLoS ONE 8 e58514 PubMed GONUTS page

[PMID:21156799-2] 2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 Bansal, K & Balaji, KN (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J. Biol. Chem. 286 5823-35 PubMed GONUTS page

[PMID:16203728-3] McDonald, C et al. (2005) A role for Erbin in the regulation of Nod2-dependent NF-kappaB signaling. J. Biol. Chem. 280 40301-9 PubMed GONUTS page

[PMID:18855982-4] Cruickshank, SM et al. (2008) Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival. World J. Gastroenterol. 14 5834-41 PubMed GONUTS page

[PMID:20008287-5] Asano, J et al. (2010) Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J. Immunol. 184 736-45 PubMed GONUTS page

[PMID:15620648-6] Abbott, DW et al. (2004) The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14 2217-27 PubMed GONUTS page

[PMID:21873635-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19139201-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page

[PMID:15220916-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page

[PMID:18167348-10] 10.0 ^10.1 Röhrl, J et al. (2008) Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3. J. Biol. Chem. 283 5414-9 PubMed GONUTS page

[PMID:15692051-11] 11.00 ^11.01 ^11.02 ^11.03 ^11.04 ^11.05 ^11.06 ^11.07 ^11.08 ^11.09 ^11.10 ^11.11 ^11.12 ^11.13 Kobayashi, KS et al. (2005) Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307 731-4 PubMed GONUTS page

[PMID:14560001-12] 12.0 ^12.1 ^12.2 Pauleau, AL & Murray, PJ (2003) Role of nod2 in the response of macrophages to toll-like receptor agonists. Mol. Cell. Biol. 23 7531-9 PubMed GONUTS page

[PMID:16949315-13] 13.0 ^13.1 ^13.2 ^13.3 Watanabe, T et al. (2006) Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis. Immunity 25 473-85 PubMed GONUTS page

[PMID:22033934-14] 14.0 ^14.1 ^14.2 Anand, PK et al. (2011) TLR2 and RIP2 pathways mediate autophagy of Listeria monocytogenes via extracellular signal-regulated kinase (ERK) activation. J. Biol. Chem. 286 42981-91 PubMed GONUTS page

[PMID:23892723-15] Yang, S et al. (2013) Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis. Nat. Immunol. 14 927-36 PubMed GONUTS page

[PMID:18261938-16] 16.00 ^16.01 ^16.02 ^16.03 ^16.04 ^16.05 ^16.06 ^16.07 ^16.08 ^16.09 ^16.10 ^16.11 Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page

[PMID:19218085-17] Saha, S et al. (2009) PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host Microbe 5 137-50 PubMed GONUTS page

[PMID:17187069-18] 18.0 ^18.1 ^18.2 Hsu, YM et al. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8 198-205 PubMed GONUTS page

[PMID:15967716-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 ^19.5 ^19.6 Martinon, F & Tschopp, J (2005) NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26 447-54 PubMed GONUTS page

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MOUSE:NOD2

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