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MOUSE:NLRP6
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Nlrp6 (synonyms: Nalp6, Navr, Pypaf5) | |
| Protein Name(s) | NACHT, LRR and PYD domains-containing protein 6
Angiotensin II/vasopressin receptor Non-angiotensin-vasopressin receptor (ECO:0000303 with PMID:20923861[1]) Non-AVR (ECO:0000303 with PMID:20923861[1]) PYRIN-containing APAF1-like protein 5-like | |
| External Links | ||
| UniProt | Q91WS2 | |
| EMBL | JF810536 AC107815 AC162287 BC013519 BC031139 FJ222825 AY355343 | |
| CCDS | CCDS40178.2 | |
| RefSeq | NP_598707.2 XP_006536212.1 | |
| UniGene | Mm.386833 | |
| ProteinModelPortal | Q91WS2 | |
| SMR | Q91WS2 | |
| STRING | 10090.ENSMUSP00000101660 | |
| PhosphoSite | Q91WS2 | |
| EPD | Q91WS2 | |
| MaxQB | Q91WS2 | |
| PaxDb | Q91WS2 | |
| PRIDE | Q91WS2 | |
| Ensembl | ENSMUST00000183845 ENSMUST00000184560 | |
| GeneID | 101613 | |
| KEGG | mmu:101613 | |
| UCSC | uc009kiv.3 uc029wpm.2 | |
| CTD | 171389 | |
| MGI | MGI:2141990 | |
| eggNOG | ENOG410IIC5 ENOG41115SU | |
| GeneTree | ENSGT00840000129675 | |
| HOGENOM | HOG000169726 | |
| HOVERGEN | HBG108172 | |
| InParanoid | Q91WS2 | |
| PhylomeDB | Q91WS2 | |
| PRO | PR:Q91WS2 | |
| Proteomes | UP000000589 | |
| Bgee | Q91WS2 | |
| CleanEx | MM_NLRP6 | |
| ExpressionAtlas | Q91WS2 | |
| Genevisible | Q91WS2 | |
| GO | GO:0061702 GO:0031965 GO:0005886 GO:0005524 GO:0005000 GO:0007186 GO:0006954 GO:0045087 GO:0070373 GO:0043124 GO:0050777 GO:0002862 GO:0043409 GO:0034122 GO:0010506 GO:0050727 GO:0070255 GO:0009617 GO:0042060 | |
| Gene3D | 1.10.533.10 3.80.10.10 | |
| InterPro | IPR004020 IPR011029 IPR032675 IPR007111 IPR027417 | |
| Pfam | PF02758 | |
| SMART | SM01289 | |
| SUPFAM | SSF47986 SSF52540 | |
| PROSITE | PS50824 PS50837 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
ECO:0000315 |
P |
Figure 1 depicts the NLRP6 lacking mice mutants had less damage to the liver when exposed to Listeria and Salmonella infections then did wild type mice. |
complete | |||||
| GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB cascade |
ECO:0000315 |
P |
Figure 3 gives evidence that NLRP6 lacking mutant mice failed to downregulate phospho-IkappaB resulting in more NF-kappaB activation while in the wild type mice production of phospho-IkappaB peaked at 60 minutes and went down after durring Listeria infections |
complete | |||||
| GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
P |
Figure 3 indicates that NLRP6 lacking mutant mice had significantly increased ERK1/ERK2 levels while in the wild types the levels were significantly less in Listeria infections. |
complete | |||||
|
involved_in |
GO:0070373 |
negative regulation of ERK1 and ERK2 cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002862 |
negative regulation of inflammatory response to antigenic stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005000 |
vasopressin receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0009617 |
response to bacterium |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2141990 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0070255 |
regulation of mucus secretion |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
regulates_o_occurs_in:(CL:0000160) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0050777 |
negative regulation of immune response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0050727 |
regulation of inflammatory response |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
regulates_o_has_participant:(EMAPA:18939) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0043409 |
negative regulation of MAPK cascade |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0043124 |
negative regulation of I-kappaB kinase/NF-kappaB signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042277 |
peptide binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:708549 |
F |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0042060 |
wound healing |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5140329 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0034122 |
negative regulation of toll-like receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0010506 |
regulation of autophagy |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
regulates_o_occurs_in:(CL:0000160) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009617 |
response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
occurs_in:(EMAPA:32874) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009617 |
response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
has_participant:(EMAPA:18939) |
Seeded From UniProt |
complete | |
|
acts_upstream_of_or_within |
GO:0009617 |
response to bacterium |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:5085850 |
P |
has_participant:(EMAPA:18939) |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005575 |
cellular_component |
ECO:0000307 |
no biological data found used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005000 |
vasopressin receptor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:708549 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005000 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005000 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0061702 |
inflammasome complex |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0031965 |
nuclear membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Herrera, VL et al. (2011) AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol. Genomics 43 32-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Anand, PK et al. (2012) NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature 488 389-93 PubMed GONUTS page
- ↑ Chen, GY et al. (2011) A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186 7187-94 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 Wlodarska, M et al. (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156 1045-59 PubMed GONUTS page
- ↑ 6.0 6.1 Hu, B et al. (2013) Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer. Proc. Natl. Acad. Sci. U.S.A. 110 9862-7 PubMed GONUTS page
- ↑ Normand, S et al. (2011) Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. U.S.A. 108 9601-6 PubMed GONUTS page
- ↑ Huber, S et al. (2012) IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature 491 259-63 PubMed GONUTS page
c
i
n
- GO:0043124 ! negative regulation of canonical NF-kappaB signal transduction
- GO:0034122 ! negative regulation of toll-like receptor signaling pathway
- GO:0070373 ! negative regulation of ERK1 and ERK2 cascade
- GO:0050777 ! negative regulation of immune response
- GO:0043409 ! negative regulation of MAPK cascade
- GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus
- GO:0031965 ! nuclear membrane
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
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