MOUSE:NLRC5

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nlrc5
Protein Name(s)	Protein NLRC5
External Links
UniProt	C3VPR6
EMBL	FJ889356 AK220210
CCDS	CCDS59741.1
RefSeq	NP_001028379.2 XP_006531225.1 XP_006531226.1
UniGene	Mm.334720
PDB	2MJM
PDBsum	2MJM
SMR	C3VPR6
IntAct	C3VPR6
STRING	10090.ENSMUSP00000060688
PRIDE	C3VPR6
Ensembl	ENSMUST00000053085
GeneID	434341
KEGG	mmu:434341
UCSC	uc009mwj.2 uc012gio.1
CTD	84166
MGI	MGI:3612191
eggNOG	NOG265451
GeneTree	ENSGT00710000106284
HOGENOM	HOG000168392
HOVERGEN	HBG108194
InParanoid	C3VPR6
OMA	VLPQMGR
PhylomeDB	C3VPR6
Reactome	REACT_198532 REACT_219118
NextBio	409534
PRO	PR:C3VPR6
Proteomes	UP000000589
ExpressionAtlas	C3VPR6
Genevestigator	C3VPR6
GO	GO:0005829 GO:0005634 GO:0005524 GO:0000979 GO:0051607 GO:0045087 GO:0032088 GO:0060339 GO:0060335 GO:0045345 GO:0045944 GO:0060340 GO:0043549
InterPro	IPR007111 IPR027417
SUPFAM	SSF52540
PROSITE	PS50837

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
part_of	GO:0005829	cytosol	PMID:20639463^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20639463^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	PMID:20434986^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:20434986^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	PMID:20434986^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3612191 PANTHER:PTN002379766 UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002379766 UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0045345	positive regulation of MHC class I biosynthetic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002379766 UniProtKB:Q86WI3	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 UniProtKB:Q9HC29 UniProtKB:Q9Y239	P	Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000716087 RGD:1306368 UniProtKB:Q7RTR2 UniProtKB:Q86WI3 UniProtKB:Q9HC29 UniProtKB:Q9Y239 ZFIN:ZDB-GENE-061108-4	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3612191 PANTHER:PTN002379766 UniProtKB:Q86WI3	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045345	positive regulation of MHC class I biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043549	regulation of kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:23012479^[4]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	C	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86WI3	F	Seeded From UniProt	complete
involved_in	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0060335	positive regulation of interferon-gamma-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0045345	positive regulation of MHC class I biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0043549	regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	C	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	C	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86WI3 ensembl:ENSP00000262510	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Meissner, TB et al. (2010) NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. U.S.A. 107 13794-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cui, J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141 483-96 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

[PMID:20639463-1] 1.0 ^1.1 Meissner, TB et al. (2010) NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc. Natl. Acad. Sci. U.S.A. 107 13794-9 PubMed GONUTS page

[PMID:20434986-2] 2.0 ^2.1 ^2.2 Cui, J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141 483-96 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23012479-4] Archambaud, C et al. (2012) Impact of lactobacilli on orally acquired listeriosis. Proc. Natl. Acad. Sci. U.S.A. 109 16684-9 PubMed GONUTS page

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MOUSE:NLRC5

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