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MOUSE:NGBR
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Nus1 (ECO:0000312 with MGI:MGI:1196365) (synonyms: D10Ertd438e, Ngbr) | |
| Protein Name(s) | Dehydrodolichyl diphosphate syntase complex subunit Nus1 (ECO:0000305)
Di-trans,poly-cis-decaprenylcistransferase (ECO:0000305) Nogo-B receptor (ECO:0000250 with UniProtKB:Q96E22) NgBR (ECO:0000250 with UniProtKB:Q96E22) Nuclear undecaprenyl pyrophosphate synthase 1 homolog (ECO:0000305) | |
| External Links | ||
| UniProt | Q99LJ8 | |
| EMBL | AK155620 AK167741 AK167939 BC003223 BC018372 | |
| CCDS | CCDS23841.1 | |
| RefSeq | NP_084526.1 | |
| UniGene | Mm.199964 | |
| ProteinModelPortal | Q99LJ8 | |
| STRING | 10090.ENSMUSP00000023830 | |
| MaxQB | Q99LJ8 | |
| PRIDE | Q99LJ8 | |
| Ensembl | ENSMUST00000023830 | |
| GeneID | 52014 | |
| KEGG | mmu:52014 | |
| UCSC | uc007fbi.2 | |
| CTD | 116150 | |
| MGI | MGI:1196365 | |
| eggNOG | COG0020 | |
| GeneTree | ENSGT00390000003223 | |
| HOGENOM | HOG000007321 | |
| HOVERGEN | HBG082024 | |
| InParanoid | Q99LJ8 | |
| OMA | YVSVYDH | |
| OrthoDB | EOG773XGR | |
| PhylomeDB | Q99LJ8 | |
| TreeFam | TF332448 | |
| UniPathway | UPA00378 | |
| ChiTaRS | Nus1 | |
| NextBio | 308368 | |
| PRO | PR:Q99LJ8 | |
| Proteomes | UP000000589 | |
| Bgee | Q99LJ8 | |
| ExpressionAtlas | Q99LJ8 | |
| Genevestigator | Q99LJ8 | |
| GO | GO:0005789 GO:0016021 GO:0016765 GO:0001525 GO:0030154 GO:0032367 GO:0006486 GO:0055092 | |
| Gene3D | 3.40.1180.10 | |
| InterPro | IPR001441 | |
| Pfam | PF01255 | |
| SUPFAM | SSF64005 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0048771 |
tissue remodeling |
ECO:0000315 |
P |
figure 1C |
complete | |||||
| GO:0048844 |
artery morphogenesis |
ECO:0000315 |
P |
Figure.1D,E |
complete | |||||
| GO:0001525 |
angiogenesis |
ECO:0000315 |
P |
figure 1F |
complete | |||||
| GO:0050900 |
leukocyte migration |
ECO:0000315 |
P |
figure 2 |
complete | |||||
| GO:0090303 |
positive regulation of wound healing |
ECO:0000315 |
P |
Figure S3A,B |
complete | |||||
| GO:0010628 |
positive regulation of gene expression |
ECO:0000315 |
P |
Figure S4 |
complete | |||||
| GO:0090025 |
regulation of monocyte chemotaxis |
ECO:0000315 |
P |
Figure S6B, C,D |
complete | |||||
| GO:0005886 |
plasma membrane |
ECO:0000314 |
C |
figure 4A |
complete | |||||
| GO:0032863 |
activation of Rac GTPase activity |
ECO:0000315 |
P |
figure 4B |
complete | |||||
| GO:0031532 |
actin cytoskeleton reorganization |
ECO:0000315 |
P |
figure 4D |
complete | |||||
|
part_of |
GO:1904423 |
dehydrodolichyl diphosphate synthase complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045547 |
dehydrodolichyl diphosphate synthase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006489 |
dolichyl diphosphate biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904423 |
dehydrodolichyl diphosphate synthase complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0055092 |
sterol homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0045547 |
dehydrodolichyl diphosphate synthase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0042632 |
cholesterol homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0038084 |
vascular endothelial growth factor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0035268 |
protein mannosylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0032383 |
regulation of intracellular cholesterol transport |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:0032383 |
regulation of intracellular cholesterol transport |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0019408 |
dolichol biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0006489 |
dolichyl diphosphate biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004659 |
prenyltransferase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004659 |
prenyltransferase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904423 |
dehydrodolichyl diphosphate synthase complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051000 |
positive regulation of nitric-oxide synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0045547 |
dehydrodolichyl diphosphate synthase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0038084 |
vascular endothelial growth factor signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032383 |
regulation of intracellular cholesterol transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019408 |
dolichol biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006489 |
dolichyl diphosphate biosynthetic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004659 |
prenyltransferase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q96E22 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016765 |
transferase activity, transferring alkyl or aryl (other than methyl) groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019408 |
dolichol biosynthetic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:1904423 |
dehydrodolichyl diphosphate synthase complex |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001525 |
angiogenesis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007275 |
multicellular organism development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006486 |
protein glycosylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
UniPathway:UPA00378 |
P |
Seeded From UniProt |
complete | ||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Yu, J et al. (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc. Natl. Acad. Sci. U.S.A. 106 17511-6 PubMed GONUTS page
- ↑ 2.0 2.1 Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 Park, EJ et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20 448-57 PubMed GONUTS page
a
d
e
g
m
p
- GO:0005886 ! plasma membrane
- GO:0043536 ! positive regulation of blood vessel endothelial cell migration
- GO:0051000 ! positive regulation of nitric-oxide synthase activity
- GO:0010628 ! positive regulation of gene expression
- GO:0090303 ! positive regulation of wound healing
- GO:0004659 ! prenyltransferase activity
- GO:0006486 ! protein glycosylation
- GO:0035268 ! protein mannosylation
r
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