MOUSE:NGBR

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nus1 (ECO:0000312 with MGI:MGI:1196365) (synonyms: D10Ertd438e, Ngbr)
Protein Name(s)	Dehydrodolichyl diphosphate syntase complex subunit Nus1 (ECO:0000305) Di-trans,poly-cis-decaprenylcistransferase (ECO:0000305) Nogo-B receptor (ECO:0000250 with UniProtKB:Q96E22) NgBR (ECO:0000250 with UniProtKB:Q96E22) Nuclear undecaprenyl pyrophosphate synthase 1 homolog (ECO:0000305)
External Links
UniProt	Q99LJ8
EMBL	AK155620 AK167741 AK167939 BC003223 BC018372
CCDS	CCDS23841.1
RefSeq	NP_084526.1
UniGene	Mm.199964
ProteinModelPortal	Q99LJ8
STRING	10090.ENSMUSP00000023830
MaxQB	Q99LJ8
PRIDE	Q99LJ8
Ensembl	ENSMUST00000023830
GeneID	52014
KEGG	mmu:52014
UCSC	uc007fbi.2
CTD	116150
MGI	MGI:1196365
eggNOG	COG0020
GeneTree	ENSGT00390000003223
HOGENOM	HOG000007321
HOVERGEN	HBG082024
InParanoid	Q99LJ8
OMA	YVSVYDH
OrthoDB	EOG773XGR
PhylomeDB	Q99LJ8
TreeFam	TF332448
UniPathway	UPA00378
ChiTaRS	Nus1
NextBio	308368
PRO	PR:Q99LJ8
Proteomes	UP000000589
Bgee	Q99LJ8
ExpressionAtlas	Q99LJ8
Genevestigator	Q99LJ8
GO	GO:0005789 GO:0016021 GO:0016765 GO:0001525 GO:0030154 GO:0032367 GO:0006486 GO:0055092
Gene3D	3.40.1180.10
InterPro	IPR001441
Pfam	PF01255
SUPFAM	SSF64005

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0048771	tissue remodeling	PMID:19805174^[1]	ECO:0000315			P		figure 1C	complete
	GO:0048844	artery morphogenesis	PMID:19805174^[1]	ECO:0000315			P		Figure.1D,E	complete
	GO:0001525	angiogenesis	PMID:19805174^[1]	ECO:0000315			P		figure 1F	complete
	GO:0050900	leukocyte migration	PMID:19805174^[1]	ECO:0000315			P		figure 2	complete
	GO:0090303	positive regulation of wound healing	PMID:19805174^[1]	ECO:0000315			P		Figure S3A,B	complete
	GO:0010628	positive regulation of gene expression	PMID:19805174^[1]	ECO:0000315			P		Figure S4	complete
	GO:0090025	regulation of monocyte chemotaxis	PMID:19805174^[1]	ECO:0000315			P		Figure S6B, C,D	complete
	GO:0005886	plasma membrane	PMID:19805174^[1]	ECO:0000314			C		figure 4A	complete
	GO:0032863	activation of Rac GTPase activity	PMID:19805174^[1]	ECO:0000315			P		figure 4B	complete
	GO:0031532	actin cytoskeleton reorganization	PMID:19805174^[1]	ECO:0000315			P		figure 4D	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96E22	C		Seeded From UniProt	complete
enables	GO:0045547	dehydrodolichyl diphosphate synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96E22	F		Seeded From UniProt	complete
involved_in	GO:0006489	dolichyl diphosphate biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055092	sterol homeostasis	PMID:19723497^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
enables	GO:0045547	dehydrodolichyl diphosphate synthase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042632	cholesterol homeostasis	PMID:25066056^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035268	protein mannosylation	PMID:25066056^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032383	regulation of intracellular cholesterol transport	PMID:19723497^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032383	regulation of intracellular cholesterol transport	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019408	dolichol biosynthetic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:25066056^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006489	dolichyl diphosphate biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	C		Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	PMID:25066056^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
contributes_to	GO:0004659	prenyltransferase activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q96E22	F		Seeded From UniProt	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	C		Seeded From UniProt	complete
involved_in	GO:0051000	positive regulation of nitric-oxide synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
enables	GO:0045547	dehydrodolichyl diphosphate synthase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
involved_in	GO:0032383	regulation of intracellular cholesterol transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
involved_in	GO:0019408	dolichol biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
involved_in	GO:0006489	dolichyl diphosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	C		Seeded From UniProt	complete
enables	GO:0004659	prenyltransferase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q96E22 ensembl:ENSP00000357480	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	P		Seeded From UniProt	complete
enables	GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001441 InterPro:IPR036424	F		Seeded From UniProt	complete
involved_in	GO:0019408	dolichol biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	P		Seeded From UniProt	complete
part_of	GO:1904423	dehydrodolichyl diphosphate synthase complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR038887	C		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
involved_in	GO:0006486	protein glycosylation	GO_REF:0000041	ECO:0000322	imported manually asserted information used in automatic assertion	UniPathway:UPA00378	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Yu, J et al. (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc. Natl. Acad. Sci. U.S.A. 106 17511-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Park, EJ et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20 448-57 PubMed GONUTS page

[PMID:19805174-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Yu, J et al. (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc. Natl. Acad. Sci. U.S.A. 106 17511-6 PubMed GONUTS page

[PMID:19723497-2] 2.0 ^2.1 Harrison, KD et al. (2009) Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metab. 10 208-18 PubMed GONUTS page

[PMID:25066056-3] 3.0 ^3.1 ^3.2 ^3.3 Park, EJ et al. (2014) Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metab. 20 448-57 PubMed GONUTS page

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MOUSE:NGBR

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