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PMID:19805174
| Citation |
Yu, J, Fernández-Hernando, C, Suarez, Y, Schleicher, M, Hao, Z, Wright, PL, DiLorenzo, A, Kyriakides, TR and Sessa, WC (2009) Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proc. Natl. Acad. Sci. U.S.A. 106:17511-6 |
|---|---|
| Abstract |
Blood vessel formation during ischemia and wound healing requires coordination of the inflammatory response with genes that regulate blood vessel assembly. Here we show that the reticulon family member 4B, aka Nogo-B, is upregulated in response to ischemia and is necessary for blood flow recovery secondary to ischemia and wound healing. Mice lacking Nogo-B exhibit reduced arteriogenesis and angiogenesis that are linked to a decrease in macrophage infiltration and inflammatory gene expression in vivo. Bone marrow-derived macrophages isolated from Nogo knock-out mice have reduced spreading and chemotaxis due to impaired Rac activation. Bone marrow reconstitution experiments show that Nogo in myeloid cells is necessary to promote macrophage homing and functional recovery after limb ischemia. Thus, endogenous Nogo coordinates macrophage-mediated inflammation with arteriogenesis, wound healing, and blood flow control. |
| Links |
PubMed PMC2762666 Online version:10.1073/pnas.0907359106 |
| Keywords |
Animals; Blood Flow Velocity/physiology; Cell Movement/physiology; Inflammation/prevention & control; Ischemia/physiopathology; Ischemia/prevention & control; Macrophages/drug effects; Macrophages/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes/drug effects; Monocytes/physiology; Myelin Proteins/deficiency; Myelin Proteins/genetics; Myelin Proteins/pharmacology; Myelin Proteins/physiology; Regional Blood Flow/physiology; Up-Regulation; Wound Healing/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0048771 : tissue remodeling |
ECO:0000315: |
P |
figure 1C |
complete | ||||
| GO:0048844 : artery morphogenesis |
ECO:0000315: |
P |
Figure.1D,E |
complete | ||||
| GO:0090303 : positive regulation of wound healing |
ECO:0000315: |
P |
Figure S3A,B |
complete | ||||
See also
References
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