MOUSE:NF2L2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nfe2l2 (synonyms: Nrf-2, Nrf2)
Protein Name(s)	Nuclear factor erythroid 2-related factor 2 NF-E2-related factor 2 NFE2-related factor 2 Nuclear factor, erythroid derived 2, like 2
External Links
UniProt	Q60795
EMBL	U70475 U70474 AK142347 AL772404 BC026943 U20532
CCDS	CCDS16150.1
PIR	I49261
RefSeq	NP_035032.1
UniGene	Mm.1025
PDB	1X2R 2DYH 3WN7
PDBsum	1X2R 2DYH 3WN7
ProteinModelPortal	Q60795
SMR	Q60795
BioGrid	201744
IntAct	Q60795
MINT	MINT-1744109
ChEMBL	CHEMBL1075148
PhosphoSite	Q60795
PaxDb	Q60795
PRIDE	Q60795
Ensembl	ENSMUST00000102672
GeneID	18024
KEGG	mmu:18024
UCSC	uc008keq.1
CTD	4780
MGI	MGI:108420
eggNOG	NOG309753
GeneTree	ENSGT00550000074399
HOGENOM	HOG000234410
HOVERGEN	HBG052609
InParanoid	Q60795
KO	K05638
OMA	TKDKHSS
OrthoDB	EOG715Q3N
PhylomeDB	Q60795
TreeFam	TF326681
ChiTaRS	Nfe2l2
EvolutionaryTrace	Q60795
NextBio	293087
PRO	PR:Q60795
Proteomes	UP000000589
Bgee	Q60795
CleanEx	MM_NFE2L2
Genevestigator	Q60795
GO	GO:0005813 GO:0000785 GO:0005737 GO:0005829 GO:0005634 GO:0005886 GO:0003677 GO:0000980 GO:0001205 GO:0003700 GO:0070301 GO:0071499 GO:0034599 GO:0071356 GO:0030968 GO:2000352 GO:1902176 GO:0030194 GO:2000379 GO:0045944 GO:0036091 GO:0045893 GO:0010499 GO:0043161 GO:0016567 GO:0045995 GO:2000121 GO:0006355
Gene3D	1.10.880.10
InterPro	IPR004827 IPR004826 IPR029845 IPR008917
PANTHER	PTHR24411:SF3
Pfam	PF03131
SMART	SM00338
SUPFAM	SSF47454
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005634	nucleus	PMID:20978343^[1]	ECO:0000314			C		Figure 6A. Inhibition of src kinases increases accumulation of nuclear Nrf2	complete
	GO:0005737	cytoplasm	PMID:20978343^[1]	ECO:0000314			C		cellular fractionation studies showed that cytosolic Nrf2 levels were slightly higher in cd36–/– VSMCs than in WT VSMCs (Figure 5D)	complete
	GO:0016563	transcription activator activity	PMID:20978343^[1]	ECO:0000314			F		immunoblots of lysates from VSMC cells demonstrated dramatic upregulation of Prdx2 expression compared with that of cells transfected with a control plasmid, empty pCDNA3 (Figure 4D).	complete
	GO:0030528	transcription regulator activity	PMID:20978343^[1]	ECO:0000314			F		immunoblots of lysates from VSMC cells demonstrated dramatic upregulation of Prdx2 expression compared with that of cells transfected with a control plasmid, empty pCDNA3 (Figure 4D).	complete
	GO:0010671	negative regulation of oxygen and reactive oxygen species metabolic process	PMID:20978343^[1]	ECO:0000315			P		Figure 7B. shRNA-based gene knockdown of nrf2 in cd36–/– cells significantly increased FeCl3-induced superoxide formation when compared with cd36–/– cells	complete
	GO:0005739	mitochondrion	PMID:22072718^[2]	ECO:0000314			C		Fig. 6A	complete CACAO 3006
	GO:0043066	negative regulation of apoptosis	PMID:22072718^[2]	ECO:0000315			P		Fig. 9CD	complete CACAO 3007
	GO:1902037	negative regulation of hematopoietic stem cell differentiation	PMID:23434824^[3]	ECO:0000315			P		Figure 2: Moreover, we found a significantly increased level of Ki-67 expression on LSKs from Nrf2−/− when compared with WT bone marrow in vivo (Fig. 2c), in concordance with the enhanced proliferation observed in vitro.	complete CACAO 7194
	GO:0046326	positive regulation of glucose import	PMID:24024172^[4]	ECO:0000314			P		Figure 1A shows that the activation of the Nrf2 gene results in an increase in the amount of glucose able to be taken in.	complete CACAO 9774
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17920186^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17920186^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15574414^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(NCBI_Gene:18104)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17920186^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O95718-3	F		Seeded From UniProt	complete
involved_in	GO:0036499	PERK-mediated unfolded protein response	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902037	negative regulation of hematopoietic stem cell differentiation	PMID:23434824^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	PMID:14978030^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	PMID:14978030^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903788	positive regulation of glutathione biosynthetic process	PMID:14978030^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:14978030^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14978030^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P97494) part_of:(GO:0042149) part_of:(GO:1903788)\|has_regulation_target(UniProtKB:Q64669) part_of:(GO:0042149) part_of:(GO:1903788)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14978030^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0042149)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14978030^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:14978030^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O54790	P	has_regulation_target:(UniProtKB:P35639)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
part_of	GO:0032993	protein-DNA complex	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0034976)	Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:24024172^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17015834^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10037736^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:10037736^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	PMID:10037736^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000121	regulation of removal of superoxide radicals	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030194	positive regulation of blood coagulation	PMID:20978343^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:23043106^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23043106^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:20978343^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
involved_in	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696686	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 MGI:MGI:97308 MGI:MGI:99421 PANTHER:PTN000696622 RGD:620360 UniProtKB:Q14494 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108420 PANTHER:PTN000696622 UniProtKB:Q16236 ZFIN:ZDB-GENE-030723-2	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000696622 RGD:620360 ZFIN:ZDB-GENE-030723-2	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071498	cellular response to fluid shear stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061396	regulation of transcription from RNA polymerase II promoter in response to copper ion	PMID:24462598^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060548	negative regulation of cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046223	aflatoxin catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045995	regulation of embryonic development	PMID:15087497^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858732	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15087497^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1858732	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15870285^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045766	positive regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045454	cell redox homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035690	cellular response to drug	PMID:24486487^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386080	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	PMID:20978266^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:24486487^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2385925	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12220541^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14517290^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9Z2X8	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15870285^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15087497^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:12220541^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15870285^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14517290^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:12220541^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	F		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q16236	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620360	F		Seeded From UniProt	complete
involved_in	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:1904385	cellular response to angiotensin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0046223	aflatoxin catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	F		Seeded From UniProt	complete
involved_in	GO:0043536	positive regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	C		Seeded From UniProt	complete
enables	GO:0001221	transcription cofactor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O54968 ensembl:ENSRNOP00000002114	F		Seeded From UniProt	complete
enables	GO:0001102	RNA polymerase II activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F		Seeded From UniProt	complete
involved_in	GO:2000352	negative regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0071499	cellular response to laminar fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0071498	cellular response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F		Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
involved_in	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q16236 ensembl:ENSP00000380252	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR008917 InterPro:IPR029845	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827 InterPro:IPR029845	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR029845	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029845	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004826 InterPro:IPR004827 InterPro:IPR008917	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029845	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:14978030^[8]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	has_direct_input:(UniProtKB:O54790)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page
↑ ^2.0 ^2.1 Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page
↑ ^3.0 ^3.1 Tsai, JJ et al. (2013) Nrf2 regulates haematopoietic stem cell function. Nat. Cell Biol. 15 309-16 PubMed GONUTS page
↑ ^4.0 ^4.1 Heiss, EH et al. (2013) Glucose availability is a decisive factor for Nrf2-mediated gene expression. Redox Biol 1 359-65 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Zhou, W et al. (2007) ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol. Cell. Endocrinol. 278 52-62 PubMed GONUTS page
↑ Katsuoka, F et al. (2005) Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. J. Biol. Chem. 280 4483-90 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Cullinan, SB & Diehl, JA (2004) PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem. 279 20108-17 PubMed GONUTS page
↑ Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Kobayashi, A et al. (1999) Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J. Biol. Chem. 274 6443-52 PubMed GONUTS page
↑ ^11.0 ^11.1 Kim, M et al. (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287 40722-31 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Song, MO et al. (2014) The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription. Exp. Cell Res. 322 39-50 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Motohashi, H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc. Natl. Acad. Sci. U.S.A. 101 6379-84 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Ki, SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol. Cell. Biol. 25 4150-65 PubMed GONUTS page
↑ ^16.0 ^16.1 Li, B et al. (2014) Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem. Biophys. Res. Commun. 444 555-61 PubMed GONUTS page
↑ Kawatani, Y et al. (2011) Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. Blood 117 986-96 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page

[PMID:20978343-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Li, W et al. (2010) CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J. Clin. Invest. 120 3996-4006 PubMed GONUTS page

[PMID:22072718-2] 2.0 ^2.1 Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page

[PMID:23434824-3] 3.0 ^3.1 Tsai, JJ et al. (2013) Nrf2 regulates haematopoietic stem cell function. Nat. Cell Biol. 15 309-16 PubMed GONUTS page

[PMID:24024172-4] 4.0 ^4.1 Heiss, EH et al. (2013) Glucose availability is a decisive factor for Nrf2-mediated gene expression. Redox Biol 1 359-65 PubMed GONUTS page

[PMID:17920186-5] 5.0 ^5.1 ^5.2 Zhou, W et al. (2007) ERRbeta: a potent inhibitor of Nrf2 transcriptional activity. Mol. Cell. Endocrinol. 278 52-62 PubMed GONUTS page

[PMID:15574414-6] Katsuoka, F et al. (2005) Nrf2 transcriptionally activates the mafG gene through an antioxidant response element. J. Biol. Chem. 280 4483-90 PubMed GONUTS page

[PMID:14517290-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 ^7.8 Cullinan, SB et al. (2003) Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 7198-209 PubMed GONUTS page

[PMID:14978030-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 ^8.7 ^8.8 Cullinan, SB & Diehl, JA (2004) PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stress. J. Biol. Chem. 279 20108-17 PubMed GONUTS page

[PMID:17015834-9] Clements, CM et al. (2006) DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc. Natl. Acad. Sci. U.S.A. 103 15091-6 PubMed GONUTS page

[PMID:10037736-10] 10.0 ^10.1 ^10.2 Kobayashi, A et al. (1999) Molecular cloning and functional characterization of a new Cap'n' collar family transcription factor Nrf3. J. Biol. Chem. 274 6443-52 PubMed GONUTS page

[PMID:23043106-11] 11.0 ^11.1 Kim, M et al. (2012) Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation. J. Biol. Chem. 287 40722-31 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24462598-13] Song, MO et al. (2014) The role of Nrf1 and Nrf2 in the regulation of copper-responsive transcription. Exp. Cell Res. 322 39-50 PubMed GONUTS page

[PMID:15087497-14] 14.0 ^14.1 ^14.2 Motohashi, H et al. (2004) Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc. Natl. Acad. Sci. U.S.A. 101 6379-84 PubMed GONUTS page

[PMID:15870285-15] 15.0 ^15.1 ^15.2 Ki, SH et al. (2005) Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Mol. Cell. Biol. 25 4150-65 PubMed GONUTS page

[PMID:24486487-16] 16.0 ^16.1 Li, B et al. (2014) Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem. Biophys. Res. Commun. 444 555-61 PubMed GONUTS page

[PMID:20978266-17] Kawatani, Y et al. (2011) Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia. Blood 117 986-96 PubMed GONUTS page

[PMID:12220541-18] 18.0 ^18.1 ^18.2 Gong, P et al. (2002) Multiple basic-leucine zipper proteins regulate induction of the mouse heme oxygenase-1 gene by arsenite. Arch. Biochem. Biophys. 405 265-74 PubMed GONUTS page

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MOUSE:NF2L2

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