MOUSE:NDKA

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nme1 (synonyms: Nm23)
Protein Name(s)	Nucleoside diphosphate kinase A NDK A NDP kinase A Metastasis inhibition factor NM23 NDPK-A Tumor metastatic process-associated protein nm23-M1
External Links
UniProt	P15532
EMBL	M35970 M65037 U85511 AF033377 BC005629
CCDS	CCDS25247.1
PIR	A46557
RefSeq	NP_032730.1
UniGene	Mm.439702
ProteinModelPortal	P15532
SMR	P15532
BioGrid	201788
IntAct	P15532
MINT	MINT-1868955
PhosphoSite	P15532
REPRODUCTION-2DPAGE	P15532
SWISS-2DPAGE	P15532
MaxQB	P15532
PaxDb	P15532
PRIDE	P15532
Ensembl	ENSMUST00000135884
GeneID	18102
KEGG	mmu:18102
UCSC	uc007kxu.1
CTD	4830
MGI	MGI:97355
eggNOG	COG0105
HOGENOM	HOG000224564
HOVERGEN	HBG000423
InParanoid	P15532
KO	K00940
OMA	MPRERTF
OrthoDB	EOG7GJ6FG
PhylomeDB	P15532
TreeFam	TF106373
Reactome	REACT_238368
ChiTaRS	Nme1
NextBio	293271
PRO	PR:P15532
Proteomes	UP000000589
Bgee	P15532
ExpressionAtlas	P15532
Genevestigator	P15532
GO	GO:0005739 GO:0005634 GO:0005524 GO:0046872 GO:0004550 GO:0030154 GO:0006241 GO:0006897 GO:0006183 GO:0007595 GO:0030879 GO:0007399 GO:0006228
Gene3D	3.30.70.141
HAMAP	MF_00451
InterPro	IPR001564 IPR023005
Pfam	PF00334
PRINTS	PR01243
SMART	SM00562
SUPFAM	SSF54919
PROSITE	PS00469

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0043209	myelin sheath	PMID:17634366^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10650 FB:FBgn0000150 PANTHER:PTN000887110 PomBase:SPAC806.07 RGD:619877 RGD:70497 SGD:S000001550 TAIR:locus:2137936 TAIR:locus:2161922 UniProtKB:O00746 UniProtKB:P15531 UniProtKB:P22392 UniProtKB:Q59636 UniProtKB:Q8ID43 ZFIN:ZDB-GENE-000210-33 dictyBase:DDB_G0273069	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	P		Seeded From UniProt	complete
enables	GO:0043024	ribosomal small subunit binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030879	mammary gland development	PMID:12848338^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3628812	P	results_in_development_of:(EMAPA:17759)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
enables	GO:0019215	intermediate filament binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007595	lactation	PMID:12848338^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3628812	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006165	nucleoside diphosphate phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	P		Seeded From UniProt	complete
colocalizes_with	GO:0005882	intermediate filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
enables	GO:0004536	deoxyribonuclease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002762	negative regulation of myeloid leukocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:70497	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P15531	F		Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004536	P		Seeded From UniProt	complete
involved_in	GO:0006259	DNA metabolic process	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004536	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	P		Seeded From UniProt	complete
enables	GO:0043024	ribosomal small subunit binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
enables	GO:0004536	deoxyribonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P15531 ensembl:ENSP00000337060	F		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
enables	GO:0043015	gamma-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
enables	GO:0019215	intermediate filament binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
involved_in	GO:0014075	response to amine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
involved_in	GO:0006165	nucleoside diphosphate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	C		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
enables	GO:0003697	single-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
involved_in	GO:0002762	negative regulation of myeloid leukocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q05982 ensembl:ENSRNOP00000003658	F		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	F		Seeded From UniProt	complete
involved_in	GO:0006165	nucleoside diphosphate phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P		Seeded From UniProt	complete
involved_in	GO:0006183	GTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P		Seeded From UniProt	complete
involved_in	GO:0006228	UTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P		Seeded From UniProt	complete
involved_in	GO:0006241	CTP biosynthetic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001564	P		Seeded From UniProt	complete
enables	GO:0004550	nucleoside diphosphate kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.4.6	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006897	endocytosis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0254	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0009117	nucleotide metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0546	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Arnaud-Dabernat, S et al. (2003) Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene. J. Bioenerg. Biomembr. 35 19-30 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:17634366-1] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:21873635-2] Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12848338-3] 3.0 ^3.1 Arnaud-Dabernat, S et al. (2003) Knockout mice as model systems for studying nm23/NDP kinase gene functions. Application to the nm23-M1 gene. J. Bioenerg. Biomembr. 35 19-30 PubMed GONUTS page

[PMID:18614015-4] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

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MOUSE:NDKA

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