MOUSE:NANO3

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nanos3 (synonyms: Nos3)
Protein Name(s)	Nanos homolog 3 NOS-3
External Links
UniProt	P60324
EMBL	AB095973 BC119513
CCDS	CCDS22470.1
RefSeq	NP_918948.1
UniGene	Mm.216740
ProteinModelPortal	P60324
SMR	P60324
BioGrid	232660
PhosphoSite	P60324
PRIDE	P60324
Ensembl	ENSMUST00000070102
GeneID	244551
KEGG	mmu:244551
UCSC	uc009mme.1
CTD	342977
MGI	MGI:2675387
eggNOG	NOG264699
GeneTree	ENSGT00640000091383
HOGENOM	HOG000082528
HOVERGEN	HBG052575
InParanoid	P60324
OMA	PDKAKTQ
OrthoDB	EOG7PGDT1
PhylomeDB	P60324
TreeFam	TF326882
NextBio	386311
PRO	PR:P60324
Proteomes	UP000000589
Bgee	P60324
CleanEx	MM_NANOS3 MM_NOS3
ExpressionAtlas	P60324
Genevestigator	P60324
GO	GO:0005737 GO:0000932 GO:0010494 GO:0005634 GO:0048471 GO:0003723 GO:0008270 GO:0007281 GO:0007275 GO:2001234 GO:0048477 GO:0051726 GO:0006417 GO:0007283
InterPro	IPR008705 IPR024161
PANTHER	PTHR12887
Pfam	PF05741
PROSITE	PS51522

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0051726	regulation of cell cycle	PMID:18089289^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:19861488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	PMID:18089289^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P60323	P		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	PMID:18089289^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19861488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21421998^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19861488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21421998^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:18089289^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000932	P-body	PMID:19861488^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:18436203^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P	regulates_o_occurs_in:(CL:0000670)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:18436203^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2682607	P	regulates_o_occurs_in:(CL:0000670)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048477	oogenesis	PMID:12947200^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2682607	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017148	negative regulation of translation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007283	spermatogenesis	PMID:12947200^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2682607	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007281	germ cell development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60323	C		Seeded From UniProt	complete
involved_in	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	C		Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	P		Seeded From UniProt	complete
involved_in	GO:0007281	germ cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60323 ensembl:ENSP00000341992	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008705	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR008705	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0048477	oogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0896	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0744	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0496	C		Seeded From UniProt	complete
part_of	GO:0000932	P-body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0230	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Lolicato, F et al. (2008) Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population. Dev. Biol. 313 725-38 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Yamaji, M et al. (2010) Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction 139 381-93 PubMed GONUTS page
↑ ^3.0 ^3.1 Julaton, VT & Reijo Pera, RA (2011) NANOS3 function in human germ cell development. Hum. Mol. Genet. 20 2238-50 PubMed GONUTS page
↑ ^4.0 ^4.1 Suzuki, H et al. (2008) Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev. Biol. 318 133-42 PubMed GONUTS page
↑ ^5.0 ^5.1 Tsuda, M et al. (2003) Conserved role of nanos proteins in germ cell development. Science 301 1239-41 PubMed GONUTS page

[PMID:18089289-1] 1.0 ^1.1 ^1.2 ^1.3 Lolicato, F et al. (2008) Potential role of Nanos3 in maintaining the undifferentiated spermatogonia population. Dev. Biol. 313 725-38 PubMed GONUTS page

[PMID:19861488-2] 2.0 ^2.1 ^2.2 ^2.3 Yamaji, M et al. (2010) Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction 139 381-93 PubMed GONUTS page

[PMID:21421998-3] 3.0 ^3.1 Julaton, VT & Reijo Pera, RA (2011) NANOS3 function in human germ cell development. Hum. Mol. Genet. 20 2238-50 PubMed GONUTS page

[PMID:18436203-4] 4.0 ^4.1 Suzuki, H et al. (2008) Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev. Biol. 318 133-42 PubMed GONUTS page

[PMID:12947200-5] 5.0 ^5.1 Tsuda, M et al. (2003) Conserved role of nanos proteins in germ cell development. Science 301 1239-41 PubMed GONUTS page

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MOUSE:NANO3

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