MOUSE:MKNK2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mknk2 (synonyms: Mnk2)
Protein Name(s)	MAP kinase-interacting serine/threonine-protein kinase 2 MAP kinase signal-integrating kinase 2 MAPK signal-integrating kinase 2 Mnk2
External Links
UniProt	Q8CDB0
EMBL	AB164081 AK008277 AK030830 AK154235 Y11092 BC010256
CCDS	CCDS24030.1
RefSeq	NP_067437.2 XP_006513379.1
UniGene	Mm.42126 Mm.486332
ProteinModelPortal	Q8CDB0
SMR	Q8CDB0
BioGrid	201432
IntAct	Q8CDB0
MINT	MINT-1524069
STRING	10090.ENSMUSP00000072412
PhosphoSite	Q8CDB0
PRIDE	Q8CDB0
Ensembl	ENSMUST00000003433
GeneID	17347
KEGG	mmu:17347
UCSC	uc007gee.2
CTD	2872
MGI	MGI:894279
eggNOG	COG0515
GeneTree	ENSGT00770000120509
HOGENOM	HOG000231140
HOVERGEN	HBG106949
InParanoid	Q8CDB0
KO	K04372
OrthoDB	EOG7SV0VB
PhylomeDB	Q8CDB0
TreeFam	TF314050
ChiTaRS	Mknk2
NextBio	291936
PRO	PR:Q8CDB0
Proteomes	UP000000589
Bgee	Q8CDB0
CleanEx	MM_MKNK2
ExpressionAtlas	Q8CDB0
Genevestigator	Q8CDB0
GO	GO:0005737 GO:0005730 GO:0016605 GO:0005524 GO:0046872 GO:0004674 GO:0071243 GO:0097192 GO:0030097 GO:0035556 GO:0006468 GO:0006417
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0035556	intracellular signal transduction	PMID:9155017^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9155017^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9155017^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9155017^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681419 TAIR:locus:2011201 TAIR:locus:2034720 TAIR:locus:2062764 TAIR:locus:2063197 TAIR:locus:2074338 TAIR:locus:2128409 TAIR:locus:2152876 TAIR:locus:2175503 TAIR:locus:2177023 TAIR:locus:2827528 UniProtKB:Q0D715 UniProtKB:Q8IW41 WB:WBGene00010681	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:894279 MGI:MGI:894316 PANTHER:PTN000681419 UniProtKB:Q9BUB5 UniProtKB:Q9HBH9	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681419 RGD:1559603 UniProtKB:P49137 UniProtKB:Q16644 UniProtKB:Q9BUB5	P		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681419 TAIR:locus:2827528 UniProtKB:P62344 UniProtKB:Q8ICR0	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0017581 MGI:MGI:109298 MGI:MGI:1333110 MGI:MGI:88258 PANTHER:PTN000681419 SGD:S000001654 TAIR:locus:2103498 TAIR:locus:2150225 TAIR:locus:2177023 TAIR:locus:2204340 UniProtKB:P49137 UniProtKB:P93759 UniProtKB:Q53P85 WB:WBGene00007007 WB:WBGene00010681 dictyBase:DDB_G0293656	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109298 MGI:MGI:1333110 MGI:MGI:88258 PANTHER:PTN000681419 TAIR:locus:2061290 TAIR:locus:2103498 TAIR:locus:2204340 UniProtKB:P49137 WB:WBGene00007007 WB:WBGene00011304	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681419 TAIR:locus:2062764 TAIR:locus:2063197 UniProtKB:Q8I534	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000681419 RGD:2264 TAIR:locus:2063197 UniProtKB:Q16566 UniProtKB:Q8IDV5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:17903173^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:894316	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:17903173^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3052675	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071243	cellular response to arsenic-containing substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030097	hemopoiesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9HBH9	F		Seeded From UniProt	complete
involved_in	GO:0071243	cellular response to arsenic-containing substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9HBH9 ensembl:ENSP00000250896	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Waskiewicz, AJ et al. (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16 1909-20 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Chrestensen, CA et al. (2007) Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells 12 1133-40 PubMed GONUTS page

[PMID:9155017-1] 1.0 ^1.1 ^1.2 ^1.3 Waskiewicz, AJ et al. (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16 1909-20 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17903173-3] 3.0 ^3.1 Chrestensen, CA et al. (2007) Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells 12 1133-40 PubMed GONUTS page

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MOUSE:MKNK2

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References

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