MOUSE:MFN2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mfn2 (synonyms: Kiaa0214, Marf)
Protein Name(s)	Mitofusin-2 Hypertension-related protein 1 Mitochondrial assembly regulatory factor HSG protein Transmembrane GTPase MFN2
External Links
UniProt	Q80U63
EMBL	AY123975 AY028170 AB048831 AF384100 AK042080 AK049583 AK052689 AK122220 AL607066 AL607066 BC046503
CCDS	CCDS38965.1
RefSeq	NP_001272849.1 NP_001272850.1 NP_001272851.1 NP_001272852.1 NP_573464.2 XP_006538672.1 XP_006538673.1 XP_006538674.1
UniGene	Mm.154312 Mm.437499
ProteinModelPortal	Q80U63
SMR	Q80U63
BioGrid	228398
DIP	DIP-60970N
IntAct	Q80U63
MINT	MINT-8057620
STRING	10090.ENSMUSP00000030884
iPTMnet	Q80U63
PhosphoSitePlus	Q80U63
EPD	Q80U63
PaxDb	Q80U63
PeptideAtlas	Q80U63
PRIDE	Q80U63
Ensembl	ENSMUST00000030884 ENSMUST00000105714 ENSMUST00000105715 ENSMUST00000105716
GeneID	170731
KEGG	mmu:170731
UCSC	uc008vtg.2 uc008vtj.2
CTD	9927
MGI	MGI:2442230
eggNOG	KOG0448 COG0699
GeneTree	ENSGT00390000013727
HOVERGEN	HBG052465
InParanoid	Q80U63
KO	K06030
OMA	MNVESAQ
OrthoDB	EOG091G02ES
PhylomeDB	Q80U63
TreeFam	TF314289
Reactome	[www.reactome.org/content/detail/R-MMU-5205685 R-MMU-5205685] [www.reactome.org/content/detail/R-MMU-983231 R-MMU-983231]
PRO	PR:Q80U63
Proteomes	UP000000589
Bgee	ENSMUSG00000029020
CleanEx	MM_MFN2
ExpressionAtlas	Q80U63
Genevisible	Q80U63
GO	GO:0005829 GO:0016021 GO:0031306 GO:0015630 GO:0005739 GO:0005525 GO:0003924 GO:0031625 GO:0006915 GO:0001825 GO:0048593 GO:0008053 GO:0007006 GO:0051646 GO:0046580 GO:0048662 GO:0061734 GO:0034497 GO:0006626 GO:0006986
Gene3D	3.40.50.300
InterPro	IPR022812 IPR006884 IPR030381 IPR027089 IPR027417
PANTHER	PTHR10465:SF9
Pfam	PF00350 PF04799
SUPFAM	SSF52540
PROSITE	PS51718

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0008053	mitochondrial fusion	PMID:15899901^[1]	ECO:0000315			P		Mfn2 demonstrates positive regulation of mitochondrial fusion, as seen and inferred from Table 1 Uniprot Nomenclature: Mitofusin-2 (MFN2_MOUSE) Organism: Mus musculus (Mouse)	complete CACAO 12465
	GO:0030307	positive regulation of cell growth	PMID:15899901^[1]	ECO:0000316		UniProtKB:Q811U4 UniProtKB:P10415	P		Reintroduction of Mfn2 and Mfn1 in growth defected cells, showed cell growth rescue (as seen at Figure 3B) with human cells. Uniprot Nomenclature: Mitofusin-2 (MFN2_MOUSE) Uniprot ID: Q80U63 Uniprot Nomenclature: Apoptosis regulator Bcl-2 (Human) Uniprot ID: P10415 Organism: Homo sapiens (Human) Uniprot Nomenclature: Mitofusin-1 (MFN1_MOUSE) Uniprot ID: Q811U4 Organism: Mus musculus (Mouse)	complete CACAO 12470
	GO:0070584	mitochondrion morphogenesis	PMID:15899901^[1]	ECO:0000316		UniProtKB:Q811U4	P		Mfn-dm (double mutant) cells revealed the necessity of Mfn1 and Mfn2 for mitochondrial morphology, Therefore through this double mutant, the reliance of Mfn2 and Mfn1 for Mitochondrial morphology is confirmed. Seen in FIG. 1. Mitofusin-2 and Mitofusin-1 Mus musculus (Mouse)	complete CACAO 12707
	GO:0008053	mitochondrial fusion	PMID:15899901^[1]	ECO:0000316		UniProtKB:Q811U4	P		Mfn-dm (double mutant) cells had 0% mitochondrial fusion, as seen on Table I. Table 1 and FIG. 2 illustrate the importance of both Mfn1 and Mfn2 for mitochondrial fusion. Mitofusin-2 and Mitofusin-1 Mus musculus (Mouse)	complete CACAO 12708
	GO:0016049	cell growth	PMID:15899901^[1]	ECO:0000316		UniProtKB:Q811U4	P		Mfn-dm (double mutant) cells showed growth defects, as seen on FIG. 3. Thus, Mfn1 and Mfn2 are needed for appropriate cell growth. Mitofusin-2 and Mitofusin-1 Mus musculus (Mouse)	complete CACAO 12709
	GO:0009060	aerobic respiration	PMID:15899901^[1]	ECO:0000316		UniProtKB:Q811U4	P		Mfn-dm (double mutant) showed respiratory defects, as seen on FIG. 5. These defects were reversible, as seen in Mfn1 and Mfn2, thus showing the importance of Mfn1 and 2 for aerobic respiration. Mitofusin-2 and Mitofusin-1 Mus musculus (Mouse)	complete CACAO 12710
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:28539390^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	PMID:23620051^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000746) occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	PMID:24513856^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R500	P		Seeded From UniProt	complete
part_of	GO:0031306	intrinsic component of mitochondrial outer membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R500	C		Seeded From UniProt	complete
NOT\|involved_in	GO:0007050	cell cycle arrest	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R500	P		Seeded From UniProt	complete
involved_in	GO:0007006	mitochondrial membrane organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
involved_in	GO:0006626	protein targeting to mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8R500	C		Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000825684 UniProtKB:O95140 UniProtKB:Q8IWA4	P		Seeded From UniProt	complete
part_of	GO:0031306	intrinsic component of mitochondrial outer membrane	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000825684 RGD:628843	C		Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011596 FB:FBgn0029870 MGI:MGI:1914664 MGI:MGI:2442230 PANTHER:PTN000825684 RGD:628843 UniProtKB:O95140 UniProtKB:Q8IWA4 WB:WBGene00001509	P		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000049197 SGD:S000000383 UniProtKB:Q8IWA4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051646	mitochondrion localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
enables	GO:0051020	GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048593	camera-type eye morphogenesis	PMID:16104381^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1861626	P	has_participant:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046580	negative regulation of Ras protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
enables	GO:0043394	proteoglycan binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034497	protein localization to phagophore assembly site	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	F		Seeded From UniProt	complete
part_of	GO:0031306	intrinsic component of mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	C		Seeded From UniProt	complete
enables	GO:0017016	Ras GTPase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	F		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	PMID:16083859^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17965) part_of:(CL:0000023)\|part_of:(EMAPA:16033) part_of:(CL:0000007)\|part_of:(EMAPA:16036) part_of:(CL:0000007)\|part_of:(EMAPA:16037) part_of:(CL:0000007)\|part_of:(EMAPA:16040) part_of:(CL:0000007)\|part_of:(EMAPA:16039) part_of:(CL:0000007)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008053	mitochondrial fusion	PMID:22493254^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008053	mitochondrial fusion	PMID:12527753^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450306	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008053	mitochondrial fusion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007006	mitochondrial membrane organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006626	protein targeting to mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:20671748^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:17035996^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95140	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628843	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001825	blastocyst formation	PMID:16083859^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_formation_of:(EMAPA:16039)	Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:0046580	negative regulation of Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:0034497	protein localization to phagophore assembly site	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	F		Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:0007006	mitochondrial membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
involved_in	GO:0006626	protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95140 ensembl:ENSP00000235329	C		Seeded From UniProt	complete
enables	GO:0003924	GTPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006884 InterPro:IPR027089 InterPro:IPR027094	F		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030381	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027089	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006884	C		Seeded From UniProt	complete
involved_in	GO:0008053	mitochondrial fusion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006884 InterPro:IPR027089	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006884 InterPro:IPR027089	C		Seeded From UniProt	complete
involved_in	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027089	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
enables	GO:0005525	GTP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0342	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
involved_in	GO:0006986	response to unfolded protein	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0834	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chen, H et al. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280 26185-92 PubMed GONUTS page
↑ Mahdaviani, K et al. (2017) Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 18 1123-1138 PubMed GONUTS page
↑ Chen, Y & Dorn, GW 2nd (2013) PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340 471-5 PubMed GONUTS page
↑ Yue, W et al. (2014) A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 24 482-96 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wang, KS et al. (2005) Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Mamm. Genome 16 332-43 PubMed GONUTS page
↑ ^7.0 ^7.1 Jiang, GJ et al. (2005) Expression of HSG is essential for mouse blastocyst formation. Biochem. Biophys. Res. Commun. 335 351-5 PubMed GONUTS page
↑ Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page
↑ Chen, H et al. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160 189-200 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page
↑ Karbowski, M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 658-62 PubMed GONUTS page

[PMID:15899901-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Chen, H et al. (2005) Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J. Biol. Chem. 280 26185-92 PubMed GONUTS page

[PMID:28539390-2] Mahdaviani, K et al. (2017) Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 18 1123-1138 PubMed GONUTS page

[PMID:23620051-3] Chen, Y & Dorn, GW 2nd (2013) PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science 340 471-5 PubMed GONUTS page

[PMID:24513856-4] Yue, W et al. (2014) A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. Cell Res. 24 482-96 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 ^5.2 ^5.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16104381-6] Wang, KS et al. (2005) Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development. Mamm. Genome 16 332-43 PubMed GONUTS page

[PMID:16083859-7] 7.0 ^7.1 Jiang, GJ et al. (2005) Expression of HSG is essential for mouse blastocyst formation. Biochem. Biophys. Res. Commun. 335 351-5 PubMed GONUTS page

[PMID:22493254-8] Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page

[PMID:12527753-9] Chen, H et al. (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 160 189-200 PubMed GONUTS page

[PMID:18614015-10] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:20671748-11] Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page

[PMID:17035996-12] Karbowski, M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 658-62 PubMed GONUTS page

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MOUSE:MFN2

Contents

Annotations

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