MOUSE:MET

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Met
Protein Name(s)	Hepatocyte growth factor receptor HGF receptor HGF/SF receptor Proto-oncogene c-Met Scatter factor receptor SF receptor Tyrosine-protein kinase Met
External Links
UniProt	P16056
EMBL	Y00671 M33424
CCDS	CCDS19925.1
PIR	S01254
UniGene	Mm.86844
ProteinModelPortal	P16056
SMR	P16056
IntAct	P16056
MINT	MINT-137318
BindingDB	P16056
ChEMBL	CHEMBL3038516
PhosphoSite	P16056
MaxQB	P16056
PaxDb	P16056
PRIDE	P16056
MGI	MGI:96969
eggNOG	COG0515
HOGENOM	HOG000220900
HOVERGEN	HBG006348
InParanoid	P16056
PhylomeDB	P16056
BRENDA	2.7.10.1
ChiTaRS	Met
PMAP-CutDB	P16056
PRO	PR:P16056
Proteomes	UP000000589
CleanEx	MM_MET
Genevestigator	P16056
GO	GO:0009925 GO:0016021 GO:0016020 GO:0005524 GO:0005008 GO:0004672 GO:0000187 GO:0030534 GO:0007420 GO:0042593 GO:0048012 GO:0001889 GO:0014812 GO:0007517 GO:0051450 GO:0014902 GO:0001890 GO:0050918 GO:2001028 GO:0010828 GO:0046777 GO:0060665 GO:0060079 GO:0050804 GO:0071526 GO:0007519
Gene3D	2.130.10.10 2.60.40.10
InterPro	IPR013783 IPR014756 IPR002909 IPR011009 IPR016201 IPR002165 IPR000719 IPR017441 IPR001627 IPR001245 IPR008266 IPR020635 IPR016244 IPR015943
Pfam	PF07714 PF01437 PF01403 PF01833
PIRSF	PIRSF000617
PRINTS	PR00109
SMART	SM00429 SM00423 SM00630 SM00219
SUPFAM	SSF101912 SSF103575 SSF56112 SSF81296
PROSITE	PS00107 PS50011 PS00109 PS51004

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0007268	synaptic transmission	PMID:21490227^[1]	ECO:0000315			P		Figure 3F, G showed that KO Met mice had a higher synaptic strength input (amplitude) from layer 2/3 to corticostriatal neurons compared to wild type.	complete CACAO 3273
	GO:0060079	regulation of excitatory postsynaptic membrane potential	PMID:21490227^[1]	ECO:0000315			P		Figure 5D, shows that knockout Met mice had greater strength in unitary EPSC than wild type, by a factor of 1.4.	complete CACAO 3274
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21490227^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:21490227^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21490227^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	PMID:21490227^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001028	positive regulation of endothelial cell chemotaxis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:15218527^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	PMID:15218527^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0024245 FB:FBgn0033791 PANTHER:PTN002356460 UniProtKB:A6QR62 UniProtKB:O15146 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P17948 UniProtKB:P21860 UniProtKB:P35916 UniProtKB:Q01973 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16288 UniProtKB:Q16620	C		Seeded From UniProt	complete
involved_in	GO:0031016	pancreas development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
enables	GO:0017147	Wnt-protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015380 FB:FBgn0033791 MGI:MGI:101766 PANTHER:PTN002521290	F		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101766 PANTHER:PTN002521290	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 MGI:MGI:96969 PANTHER:PTN002814495 RGD:3082 WB:WBGene00020504 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0283499 MGI:MGI:104757 MGI:MGI:109378 MGI:MGI:1096337 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95278 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95523 MGI:MGI:95524 MGI:MGI:95525 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96575 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97531 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99216 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2612 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 RGD:69323 UniProtKB:A6QR62 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:P54764 UniProtKB:Q02763 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q15375 UniProtKB:Q16288 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 WB:WBGene00001184 WB:WBGene00006868 ZFIN:ZDB-GENE-020503-1 ZFIN:ZDB-GENE-020503-2 ZFIN:ZDB-GENE-060503-14 ZFIN:ZDB-GENE-070713-2 ZFIN:ZDB-GENE-980526-255 ZFIN:ZDB-GENE-980526-326 ZFIN:ZDB-GENE-990415-62	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347244 PANTHER:PTN001231011 RGD:69283 UniProtKB:P30530 UniProtKB:Q12866	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003366 FB:FBgn0003731 FB:FBgn0003733 FB:FBgn0011829 FB:FBgn0015380 FB:FBgn0032006 FB:FBgn0283499 MGI:MGI:103581 MGI:MGI:104771 MGI:MGI:109378 MGI:MGI:98277 MGI:MGI:99611 PANTHER:PTN002356460 RGD:1560587 RGD:3213 RGD:3214 RGD:70957 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07949 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q02763 UniProtKB:Q16620 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00000898	C		Seeded From UniProt	complete
enables	GO:0005008	hepatocyte growth factor-activated receptor activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96969 PANTHER:PTN002814515 RGD:3082	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003733 FB:FBgn0040505 FB:FBgn0283499 MGI:MGI:109378 MGI:MGI:1339758 MGI:MGI:1345277 MGI:MGI:95276 MGI:MGI:95294 MGI:MGI:95522 MGI:MGI:95524 MGI:MGI:95558 MGI:MGI:95561 MGI:MGI:96677 MGI:MGI:96683 MGI:MGI:96969 MGI:MGI:97384 MGI:MGI:97530 MGI:MGI:97902 MGI:MGI:98277 MGI:MGI:99611 MGI:MGI:99612 MGI:MGI:99654 PANTHER:PTN002356460 RGD:2543 RGD:2611 RGD:2621 RGD:2869 RGD:2917 RGD:2965 RGD:3082 RGD:3213 RGD:3214 RGD:3284 RGD:3285 RGD:620144 RGD:620714 RGD:620831 RGD:621737 UniProtKB:P00533 UniProtKB:P04626 UniProtKB:P04629 UniProtKB:P06213 UniProtKB:P07333 UniProtKB:P07949 UniProtKB:P08069 UniProtKB:P09619 UniProtKB:P10721 UniProtKB:P11362 UniProtKB:P14616 UniProtKB:P16234 UniProtKB:P17948 UniProtKB:P21709 UniProtKB:P21802 UniProtKB:P22455 UniProtKB:P22607 UniProtKB:P29317 UniProtKB:P29320 UniProtKB:P35916 UniProtKB:P35968 UniProtKB:P54753 UniProtKB:P54760 UniProtKB:P54762 UniProtKB:Q08345 UniProtKB:Q15303 UniProtKB:Q16620 UniProtKB:Q16832 UniProtKB:Q5JZY3 UniProtKB:Q91987 UniProtKB:Q9UM73 WB:WBGene00000289 WB:WBGene00006868 WB:WBGene00020504 ZFIN:ZDB-GENE-980526-255	F		Seeded From UniProt	complete
involved_in	GO:0001889	liver development	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96969 PANTHER:PTN002814515 RGD:3082 ZFIN:ZDB-GENE-041014-1	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001028	positive regulation of endothelial cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900745	positive regulation of p38MAPK cascade	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900407	regulation of cellular response to oxidative stress	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072593	reactive oxygen species metabolic process	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071635	negative regulation of transforming growth factor beta production	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070495	negative regulation of thrombin-activated receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061436	establishment of skin barrier	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	PMID:14517989^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0060076	excitatory synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060048	cardiac muscle contraction	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0055013	cardiac muscle cell development	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051497	negative regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051450	myoblast proliferation	PMID:11061428^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858021	P	occurs_in:(EMAPA:18521) acts_on_population_of:(CL:0000515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050775	positive regulation of dendrite morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048012	hepatocyte growth factor receptor signaling pathway	PMID:15314156^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:15314156^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045840	positive regulation of mitotic nuclear division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
enables	GO:0043274	phospholipase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:16049329^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176227,MGI:MGI:3041135	P		Seeded From UniProt	complete
part_of	GO:0036126	sperm flagellum	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035024	negative regulation of Rho protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032675	regulation of interleukin-6 production	PMID:21072211^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031116	positive regulation of microtubule polymerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030534	adult behavior	PMID:12397180^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450967	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030317	flagellated sperm motility	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7565774^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014902	myotube differentiation	PMID:7651534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:17883)\|occurs_in:(EMAPA:16405)\|occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014812	muscle cell migration	PMID:7651534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:16184)\|occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010828	positive regulation of glucose transmembrane transport	PMID:16049329^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176227,MGI:MGI:3041135	P	regulates_o_occurs_in:(EMAPA:32927) regulates_o_occurs_in:(CL:0000169)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	PMID:23994610^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3041135	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
part_of	GO:0009925	basal plasma membrane	PMID:15314156^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	C		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007519	skeletal muscle tissue development	PMID:7651534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	results_in_development_of:(EMAPA:17883)\|results_in_development_of:(EMAPA:16405)\|results_in_development_of:(EMAPA:17701)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007517	muscle organ development	PMID:15376315^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97487	P	results_in_development_of:(EMAPA:18276)\|results_in_development_of:(EMAPA:18277)\|results_in_development_of:(EMAPA:17701)\|results_in_development_of:(EMAPA:19070)\|results_in_development_of:(EMAPA:19067)\|results_in_development_of:(EMAPA:18177)\|results_in_development_of:(EMAPA:18179)\|results_in_development_of:(EMAPA:18180)\|results_in_development_of:(EMAPA:18178)\|results_in_development_of:(EMAPA:16405)\|results_in_development_of:(EMAPA:17844)\|results_in_development_of:(EMAPA:18190)\|results_in_development_of:(EMAPA:18276)\|results_in_development_of:(EMAPA:18277)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007517	muscle organ development	PMID:15376315^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1858019	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:12397180^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450967	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	C		Seeded From UniProt	complete
enables	GO:0005008	hepatocyte growth factor-activated receptor activity	PMID:15314156^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005008	hepatocyte growth factor-activated receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:7651534^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001890	placenta development	PMID:7651534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001889	liver development	PMID:7651534^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001886	endothelial cell morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08581	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001764	neuron migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	PMID:15314156^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BUE7	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3082	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004713	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004714	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016244 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016244	C		Seeded From UniProt	complete
enables	GO:0004714	transmembrane receptor protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.1	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Qiu, S et al. (2011) Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J. Neurosci. 31 5855-64 PubMed GONUTS page
↑ ^2.0 ^2.1 Artigiani, S et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 5 710-4 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Arechederra, M et al. (2013) Met signaling in cardiomyocytes is required for normal cardiac function in adult mice. Biochim. Biophys. Acta 1832 2204-15 PubMed GONUTS page
↑ Ikari, T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev. Dyn. 228 173-84 PubMed GONUTS page
↑ Ponzetto, C et al. (2000) Met signaling mutants as tools for developmental studies. Int. J. Dev. Biol. 44 645-53 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Higuchi, T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol. Cell. Biol. 24 7456-68 PubMed GONUTS page
↑ ^8.0 ^8.1 Dai, C et al. (2005) Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am. J. Pathol. 167 429-36 PubMed GONUTS page
↑ Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page
↑ ^10.0 ^10.1 Ieraci, A et al. (2002) Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc. Natl. Acad. Sci. U.S.A. 99 15200-5 PubMed GONUTS page
↑ Komada, M & Kitamura, N (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol. Cell. Biol. 15 6213-21 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Bladt, F et al. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376 768-71 PubMed GONUTS page
↑ ^13.0 ^13.1 Prunotto, C et al. (2004) Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev. Dyn. 231 582-91 PubMed GONUTS page

[PMID:21490227-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Qiu, S et al. (2011) Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase. J. Neurosci. 31 5855-64 PubMed GONUTS page

[PMID:15218527-2] 2.0 ^2.1 Artigiani, S et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 5 710-4 PubMed GONUTS page

[PMID:21873635-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23994610-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Arechederra, M et al. (2013) Met signaling in cardiomyocytes is required for normal cardiac function in adult mice. Biochim. Biophys. Acta 1832 2204-15 PubMed GONUTS page

[PMID:14517989-5] Ikari, T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev. Dyn. 228 173-84 PubMed GONUTS page

[PMID:11061428-6] Ponzetto, C et al. (2000) Met signaling mutants as tools for developmental studies. Int. J. Dev. Biol. 44 645-53 PubMed GONUTS page

[PMID:15314156-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Higuchi, T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol. Cell. Biol. 24 7456-68 PubMed GONUTS page

[PMID:16049329-8] 8.0 ^8.1 Dai, C et al. (2005) Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance. Am. J. Pathol. 167 429-36 PubMed GONUTS page

[PMID:21072211-9] Coudriet, GM et al. (2010) Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS ONE 5 e15384 PubMed GONUTS page

[PMID:12397180-10] 10.0 ^10.1 Ieraci, A et al. (2002) Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc. Natl. Acad. Sci. U.S.A. 99 15200-5 PubMed GONUTS page

[PMID:7565774-11] Komada, M & Kitamura, N (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol. Cell. Biol. 15 6213-21 PubMed GONUTS page

[PMID:7651534-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Bladt, F et al. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376 768-71 PubMed GONUTS page

[PMID:15376315-13] 13.0 ^13.1 Prunotto, C et al. (2004) Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev. Dyn. 231 582-91 PubMed GONUTS page

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