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PMID:7651534

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Citation

Bladt, F, Riethmacher, D, Isenmann, S, Aguzzi, A and Birchmeier, C (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768-71

Abstract

Limb muscles develop from cells that migrate from the somites. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud. Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue. In c-met homozygous mutant (-/-) mouse embryos, the limb bud and diaphragm are not colonized by myogenic precursor cells and, as a consequence, skeletal muscles of the limb and diaphragm do not form. In contrast, development of the axial skeletal muscles proceeds in the absence of c-met signalling. The specific ligand of the c-met protein, the motility and growth factor scatter factor/hepatocyte growth factor, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met. We have therefore identified a paracrine signalling system that regulates migration of myogenic precursor cells.

Links

PubMed Online version:10.1038/376768a0

Keywords

Animals; Cell Movement; Chimera; Diaphragm/embryology; Extremities/embryology; Hepatocyte Growth Factor/physiology; Mesoderm; Mice; Muscle, Skeletal/cytology; Muscle, Skeletal/embryology; Muscles/cytology; Muscles/embryology; Mutagenesis; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/physiology; Signal Transduction; Stem Cells/cytology; Tongue/embryology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:MET

acts_upstream_of_or_within

GO:0007519: skeletal muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

  • results_in_development_of:(EMAPA:17883)|results_in_development_of:(EMAPA:16405)|results_in_development_of:(EMAPA:17701)

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0014902: myotube differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

  • occurs_in:(EMAPA:17883)|occurs_in:(EMAPA:16405)|occurs_in:(EMAPA:17701)

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0014812: muscle cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

  • occurs_in:(EMAPA:16184)|occurs_in:(EMAPA:16405)

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0007519: skeletal muscle tissue development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

results_in_development_of:(EMAPA:17883)|results_in_development_of:(EMAPA:16405)|results_in_development_of:(EMAPA:17701)

Seeded From UniProt

complete

MOUSE:MET

enables

GO:0004672: protein kinase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0001890: placenta development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0001889: liver development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0014902: myotube differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

occurs_in:(EMAPA:17883)|occurs_in:(EMAPA:16405)|occurs_in:(EMAPA:17701)

Seeded From UniProt

complete

MOUSE:MET

acts_upstream_of_or_within

GO:0014812: muscle cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1857655

P

occurs_in:(EMAPA:16184)|occurs_in:(EMAPA:16405)

Seeded From UniProt

complete


See also

References

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