PMID:7651534

Citation	Bladt, F, Riethmacher, D, Isenmann, S, Aguzzi, A and Birchmeier, C (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376:768-71
Abstract	Limb muscles develop from cells that migrate from the somites. The signal that induces migration of myogenic precursor cells to the limb emanates from the mesenchyme of the limb bud. Here we report that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue. In c-met homozygous mutant (-/-) mouse embryos, the limb bud and diaphragm are not colonized by myogenic precursor cells and, as a consequence, skeletal muscles of the limb and diaphragm do not form. In contrast, development of the axial skeletal muscles proceeds in the absence of c-met signalling. The specific ligand of the c-met protein, the motility and growth factor scatter factor/hepatocyte growth factor, is expressed in limb mesenchyme and can thus provide the signal for migration which is received by c-met. We have therefore identified a paracrine signalling system that regulates migration of myogenic precursor cells.
Links	PubMed Online version:10.1038/376768a0
Keywords	Animals; Cell Movement; Chimera; Diaphragm/embryology; Extremities/embryology; Hepatocyte Growth Factor/physiology; Mesoderm; Mice; Muscle, Skeletal/cytology; Muscle, Skeletal/embryology; Muscles/cytology; Muscles/embryology; Mutagenesis; Proto-Oncogene Proteins c-met; Receptor Protein-Tyrosine Kinases/genetics; Receptor Protein-Tyrosine Kinases/physiology; Signal Transduction; Stem Cells/cytology; Tongue/embryology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:MET	acts_upstream_of_or_within	GO:0007519: skeletal muscle tissue development	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	results_in_development_of:(EMAPA:17883)|results_in_development_of:(EMAPA:16405)|results_in_development_of:(EMAPA:17701)	Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0014902: myotube differentiation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:17883)|occurs_in:(EMAPA:16405)|occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0014812: muscle cell migration	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:16184)|occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0007519: skeletal muscle tissue development	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	results_in_development_of:(EMAPA:17883)|results_in_development_of:(EMAPA:16405)|results_in_development_of:(EMAPA:17701)	Seeded From UniProt	complete
MOUSE:MET	enables	GO:0004672: protein kinase activity	ECO:0000314: direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0001890: placenta development	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P		Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0001889: liver development	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P		Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0014902: myotube differentiation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:17883)|occurs_in:(EMAPA:16405)|occurs_in:(EMAPA:17701)	Seeded From UniProt	complete
MOUSE:MET	acts_upstream_of_or_within	GO:0014812: muscle cell migration	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:1857655	P	occurs_in:(EMAPA:16184)|occurs_in:(EMAPA:16405)	Seeded From UniProt	complete

References

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