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PMID:15218527

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Citation

Artigiani, S, Conrotto, P, Fazzari, P, Gilestro, GF, Barberis, D, Giordano, S, Comoglio, PM and Tamagnone, L (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep. 5:710-4

Abstract

Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3.

Links

PubMed PMC1299100 Online version:10.1038/sj.embor.7400189

Keywords

Animals; Axons/metabolism; Blotting, Western; COS Cells; Cell Line; Cell Membrane/metabolism; Cell Movement; Dose-Response Relationship, Drug; Endothelium, Vascular/embryology; Endothelium, Vascular/metabolism; Endothelium, Vascular/pathology; Epithelial Cells/metabolism; Fibroblasts/metabolism; Humans; Immunoprecipitation; Kinetics; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Mice; NIH 3T3 Cells; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/metabolism; Nerve Tissue Proteins/physiology; Neural Cell Adhesion Molecules/metabolism; Neural Cell Adhesion Molecules/physiology; Protein Binding; Proto-Oncogene Proteins c-met/metabolism; RNA, Small Interfering/metabolism; Receptors, Cell Surface/metabolism; Signal Transduction

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:PLXB1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q92854

F

Seeded From UniProt

complete

HUMAN:PLXB1

involved_in

GO:0007162: negative regulation of cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLXB1

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SEM5A

enables

GO:0030215: semaphorin receptor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9ULL4

F

Seeded From UniProt

complete

MOUSE:SEM5A

involved_in

GO:0007162: negative regulation of cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SEM5A

involved_in

GO:0050918: positive chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SEM5A

involved_in

GO:0060326: cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SEM5A

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:SEM5A

involved_in

GO:1990256: signal clustering

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SEM4D

enables

GO:0030215: semaphorin receptor binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O43157

F

Seeded From UniProt

complete

HUMAN:SEM4D

involved_in

GO:0007162: negative regulation of cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:SEM4D

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLXB3

enables

GO:0019904: protein domain specific binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q62217

F

Seeded From UniProt

complete

HUMAN:PLXB3

involved_in

GO:0007162: negative regulation of cell adhesion

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLXB3

enables

GO:0017154: semaphorin receptor activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:PLXB3

involved_in

GO:0050918: positive chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLXB3

involved_in

GO:0060326: cell chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:PLXB3

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MET

involved_in

GO:0050918: positive chemotaxis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:MET

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MET

involved_in

GO:0071526: semaphorin-plexin signaling pathway

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:MET

involved_in

GO:0050918: positive chemotaxis

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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